Preprint > Page 4
  • bioRxiv  ·  February 3, 2026  ·  Preprint

    Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Programs in the Human Brain.

    Yang Xie, Lei Chang, Guojie Zhong, Jonathan A. Rink, Tatiana Baez-Becerra, Ethan Armand, Wubin Ding, Kai Li, Eric Boone, Audrey Lie, Hannah S Indralingam, Keyi Dong, Timothy Loe, Bohan Huang, Zhaoning Wang, Ariana S. Barcoma, Jackson K. Willier, Kyle W. Knutson, Jiayi Liu, Silvia Cho, Stella Cao, Kaitlyn G. Russo, Carissa K. Young, Jessica Arzavala, Yareli Sanchez, Aleksandra Bikkina, Natalie Schenker-Ahmed, Colin Kern, Zoey Zhao, Amit Klein, Jesus Flores, Chu-Yi Tai, Jacqueline Olness, Alexander Monell, Siavash Moghadami, Cesar Barragan, Chumo Chen, William Owens, Carolyn OConnor, Michelle Liem, Mikayla V. Marrin, Cynthia Rose, Shane N. Alt, Nora Emerson, Julia Osteen, Jacinta Lucero, Daofeng Li, Rebecca D. Hodge, Ting Wang, C. Dirk Keene, Xiangming Xu, Quan Zhu, Joseph R. Ecker, M. Margarita Behrens, Bing Ren

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  • bioRxiv  ·  January 29, 2026  ·  Preprint

    An Integrated Single-Cell and Epigenomic Resource for Comparative Analysis of the Basal Ganglia.

    Wenjin Zhang, Wubin Ding, Kai Li, Lei Chang, Amit Klein, Cindy Tatiana Baez-Becerra, Jonathan A. Rink, Anna Bartlett, Huaming Chen, Natalie Schenker, Nelson Johansen, Tyler Mollenkopf, Yuanyuan Fu, Xie Yang, Shane Liu, Chanrung Seng, Benpeng Miao, Tianjie Liu, Quan Zhu, Rebecca D. Hodge, Trygve E. Bakken, Ed S. Lein, Michael Hawrylycz, Xiangmin Xu, M. Margarita Behrens, Bing Ren, Joseph R. Ecker, Ting Wang, Daofeng Li.

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  • medRxiv  ·  January 30, 2026  ·  Preprint

    Integrating multi-omic QTLs and predictive models reveals regulatory architectures at immune related GWAS loci in CD4+ T cells.

    Marliette R Matos, Samuel Ghatan, Sean Bankier, Taylor V Thompson, Kassidy Lundy-Perez, Masako Suzuki, Reanna Doña-Termine, Jacob Stauber, David Reynolds, Kathleen Rosales, Anthony Griffen, Mariko Isshiki, Danny Simpson, Nathanael Andrews, Omar Ahmed, Samantha Gold, Sophia R Ostrowiak, Srilakshmi Raj, Sofiya Milman, Tuuli Lappalainen, John M Greally

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  • bioRxiv  ·  January 29, 2026  ·  Preprint

    SUMO2 Deletion Changes Chromatin Accessibility and Enhances Cytotoxic T Cell Activation and Tumor Infiltration

    Neranjan Tharuka Mohottige Don, Dai-Hua Chen, Maria Luisa J Amaral, Tianchen Ren, Yixuan Kuang, Shih-Ting Huang, Nikhil Chilakapati, Bing Ren, Stephen P, Schoenberger, Ye Zheng, Yuan Chen

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  • bioRxiv  ·  January 24, 2026  ·  Preprint

    A Manifold-Based Measure of Transcriptional Entropy for Quantifying Aging in Single Cells.

    Yilin Yang, Paul R. Hess, Sijia Huang, Marcos G. Teneche, Hanzhi Wang, Karl N. Miller, Andrew E. Davis, Charlene Miciano, Kelly Yichen Li, Sainath Mamde, Kevin Yip, Bing Ren, Qian Yang, Elizabeth Smoot, Allen Wang, Bradley Johnson, Parker Wilson, Peter D. Adams, Nancy R. Zhang

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  • medRxiv  ·  January 16, 2026  ·  Preprint

    Multi-molecular scores map process-specific polygenic diabetes risk to atherosclerosis, cardiometabolic diseases, and vascular complications.

    Hui Li, Jakub Morze, Martin Adiels, Joel Kullberg, Jordi Merino, Magdalena Sevilla-Gonzalez, Göran Bergström, Marju Orho-Melander, Stefan Söderberg, Carl Johan Östgren, Tuuli Lappalainen, Tove Fall, Miriam S Udler, Ida Häggström, Clemens Wittenbecher

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  • bioRxiv  ·  January 9, 2026  ·  Preprint

    TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons, crypTEs, in iPSC derived neurons and ALS/FTD patient tissues.

    Isobel Bolger, Regina Shaw, Oliver H Tam, Claudio Gouveia Roque, Christopher A Jackson, Kathryn O’neill, NYGC ALS Consortium, Colin Smith, Hemali Phatnani, Karthick Natarajan, Molly Gale Hammell.

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  • bioRxiv  ·  December 30, 2025  ·  Preprint

    Aging-associated alternative splicing programs conserved between human and mouse tissues.

    Keren Isaev, David A Knowles.

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