Preprint > Page 2
  • medRxiv  ·  March 23, 2026  ·  Preprint

    A scalable and equitable framework for target and patient prioritisation in rare disease antisense therapeutics.

    Ella F. Whittle, Kylie-Ann Montgomery, Carme Camps, Nour Elkhateeb, Catherine Ryan, Sara Aguti, Thales A. C. de Guimarães, Usha Kini, Helen Stewart, Andrew G. L. Douglas, Louise Wilson, Harry G. Leitch, David S. Lynch, Robert Robinson, Michel Michaelides, Timothy W. Yu, Paul Gissen, Marlen C. Lauffer, Nick Lench, Dan O’Connor, Ana Lisa Tavares, Stephan J. Sanders, Manju A. Kurian, Hannah Titheradge, Emma Clement, Jacqueline van der Spuy, Jenny C. Taylor, Carlo Rinaldi, Francesco Muntoni, Haiyan Zhou, Alice E. Davidson, Mina Ryten, UPNAT consortium.

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  • bioRxiv  ·  March 27, 2026  ·  Preprint

    Systematic identification of seed-driven off-target effects in Perturb-seq experiments.

    Austin Hartman, John D Blair, Thao P Nguyen, Kyle Dyson, Alexandra Bradu, Oliver Takacsi-Nagy, Katherine Santostefano, Theresa Boade, Matthew Bolanos, Ronghui Zhu, Emma Dann, Alexander Marson, Aaron Gitler, Rahul Satija, Ansuman T Satpathy, Theodore L Roth.

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  • bioRxiv  ·  March 26, 2026  ·  Preprint

    Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cancer Metastasis.

    Gu Xiao, George K. Annor, Katherine W. Harmon, Valery Chavez, Fayola Levine, Samuel Ahuno, Samantha C. St. Jean, Florencia P. Madorsky Rowdo, Pamella Leybengrub, Marie Gaglio, Viola Ellison, Divya Venkatesh, Siyu Sun, Taha Merghoub, Benjamin Greenbaum, Olivier Elemento, Melissa B. Davis, Olorunseun Ogunwobi, Jill Bargonetti.

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  • medRxiv  ·  March 28, 2026  ·  Preprint

    Integrative Genomic, Transcriptomic, and Microbiome Profiles of Colon Cancer by Ancestry Provide Insights into Molecular Distinctions.

    Melissa Kramer, Pascal Belleau, Sofia C Tortora, Astrid Deschenes, Kyriaki Founta, Carino Gurjao, Brian Yueh, Sara Goodwin, Devin Gee, Santhilal Subhash, Mali Barbi, Charlie Chung, Kadir Ozler, Onur Eskiocak, Benjamin Izar, Heather Geiger, Timothy R Chu, Zoe Goldstein, Lara Winterkorn, Andrew Araneo, Richard L Whelan, David Rivadeneira, Sharon Fox, Arjun Kandel, Fatih Ozay, Desiree Joy Anne Talabong, Olalekan Lanipekun, Henry Talus, Jianying Zeng, Arvind Rishi, Nyasha Chambwe, Nicolas Robine, Jeff Boyd, Alexander Krasnitz, Semir Beyaz, W Richard McCombie, Laura A Martello

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  • bioRxiv  ·  March 18, 2026  ·  Preprint

    Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq.

    Tuo Shi, Maria Korshunova, Seoyeon Kim, David DeTomaso, Xinhe Zheng, Lavanya Vishvanath, Thokozile Nyasulu, Nhan Huynh, Alexander Sun, Patrick C Thompson, Yifan Zhang, Emilie M Wigdor, Narjes Rohani, Salma Ali, Huixian Qiu, Michael Geralt, Zephyra Zhao, Sara Rabhi, Zizhen Yao, Cindy TJ van Velthoven, Joseph R Nery, Rosa G Castanon, Severin Dicks, Tiffany J Chen, Joseph R Ecker, Hongkui Zeng, Grace XY Zheng, Stephan J Sanders, Laksshman Sundaram, Xin Jin

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  • bioRxiv  ·  March 13, 2026  ·  Preprint

    An explainable boosting machine model for identifying artifacts caused by formalin-fixed paraffin embedding.

    Valentina Grether, Zoe R Goldstein, Jennifer M Shelton, Timothy R Chu, William F Hooper, Heather Geiger, Andre Corvelo, Rachel Martini, Melissa B Davis, Nicolas Robine, Will Liao.

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  • bioRxiv  ·  March 7, 2026  ·  Preprint

    Single-molecule spatial genomics reveals the multi-scale organization and plasticity of extrachromosomal DNA in glioblastoma.

    Brett Taylor, Weixiu Dong, Tula Keal, Zhaoning Wang, Bharath Saravanan, Zane A. Gibbs, Yohei Miyake, Daisuke Kawauchi, Raghavendra Vadla, Abhinaba Banerjee, Omar Elkassih, Sahana Kashyap, Brandon M Jones, Kseniya Malukhina, Mahsa Nafisi, Timothy H Loe, Joseph Bendik, Tom McAllister, Yang Xie, Lei Chang, Clark Chen, Bing Ren, Frank Furnari, Bogdan Bintu

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  • Genome Research  ·  March 4, 2026  ·  Preprint

    Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson’s disease.

    Kangli Wang, Weikun Xia, Yingli Gu, Songpeng Zu, Qian Yang, Maria Luisa Amaral, Yaozhi Wang, Allen Wang, Xiang-Dong Fu, William C Mobley, Bing Ren

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  • bioRxiv  ·  February 20, 2026  ·  Preprint

    Rational design of synthetic proteins using a genome-scale CRISPR screen.

    Wells Burrell, Simon J. Mueller, Zharko Daniloski, P. Duffy Doyle Jr., Anne B. Rovsing, Christopher James, Max Drabkin, Chien-Yu Chou, Hei Yu Annika So, Lyla Katgara, Akash Sookdeo, Lu Lu, Georges-Ibrahim Cisse, Rachel E Yan, Neville E Sanjana

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