Preprint > Page 3
  • medRxiv  ·  March 28, 2026  ·  Preprint

    Integrative Genomic, Transcriptomic, and Microbiome Profiles of Colon Cancer by Ancestry Provide Insights into Molecular Distinctions.

    Melissa Kramer, Pascal Belleau, Sofia C Tortora, Astrid Deschenes, Kyriaki Founta, Carino Gurjao, Brian Yueh, Sara Goodwin, Devin Gee, Santhilal Subhash, Mali Barbi, Charlie Chung, Kadir Ozler, Onur Eskiocak, Benjamin Izar, Heather Geiger, Timothy R Chu, Zoe Goldstein, Lara Winterkorn, Andrew Araneo, Richard L Whelan, David Rivadeneira, Sharon Fox, Arjun Kandel, Fatih Ozay, Desiree Joy Anne Talabong, Olalekan Lanipekun, Henry Talus, Jianying Zeng, Arvind Rishi, Nyasha Chambwe, Nicolas Robine, Jeff Boyd, Alexander Krasnitz, Semir Beyaz, W Richard McCombie, Laura A Martello

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  • bioRxiv  ·  March 18, 2026  ·  Preprint

    Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq.

    Tuo Shi, Maria Korshunova, Seoyeon Kim, David DeTomaso, Xinhe Zheng, Lavanya Vishvanath, Thokozile Nyasulu, Nhan Huynh, Alexander Sun, Patrick C Thompson, Yifan Zhang, Emilie M Wigdor, Narjes Rohani, Salma Ali, Huixian Qiu, Michael Geralt, Zephyra Zhao, Sara Rabhi, Zizhen Yao, Cindy TJ van Velthoven, Joseph R Nery, Rosa G Castanon, Severin Dicks, Tiffany J Chen, Joseph R Ecker, Hongkui Zeng, Grace XY Zheng, Stephan J Sanders, Laksshman Sundaram, Xin Jin

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  • bioRxiv  ·  March 13, 2026  ·  Preprint

    An explainable boosting machine model for identifying artifacts caused by formalin-fixed paraffin embedding.

    Valentina Grether, Zoe R Goldstein, Jennifer M Shelton, Timothy R Chu, William F Hooper, Heather Geiger, Andre Corvelo, Rachel Martini, Melissa B Davis, Nicolas Robine, Will Liao.

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  • bioRxiv  ·  March 7, 2026  ·  Preprint

    Single-molecule spatial genomics reveals the multi-scale organization and plasticity of extrachromosomal DNA in glioblastoma.

    Brett Taylor, Weixiu Dong, Tula Keal, Zhaoning Wang, Bharath Saravanan, Zane A. Gibbs, Yohei Miyake, Daisuke Kawauchi, Raghavendra Vadla, Abhinaba Banerjee, Omar Elkassih, Sahana Kashyap, Brandon M Jones, Kseniya Malukhina, Mahsa Nafisi, Timothy H Loe, Joseph Bendik, Tom McAllister, Yang Xie, Lei Chang, Clark Chen, Bing Ren, Frank Furnari, Bogdan Bintu

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  • Genome Research  ·  March 4, 2026  ·  Preprint

    Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson’s disease.

    Kangli Wang, Weikun Xia, Yingli Gu, Songpeng Zu, Qian Yang, Maria Luisa Amaral, Yaozhi Wang, Allen Wang, Xiang-Dong Fu, William C Mobley, Bing Ren

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  • bioRxiv  ·  February 20, 2026  ·  Preprint

    Rational design of synthetic proteins using a genome-scale CRISPR screen.

    Wells Burrell, Simon J. Mueller, Zharko Daniloski, P. Duffy Doyle Jr., Anne B. Rovsing, Christopher James, Max Drabkin, Chien-Yu Chou, Hei Yu Annika So, Lyla Katgara, Akash Sookdeo, Lu Lu, Georges-Ibrahim Cisse, Rachel E Yan, Neville E Sanjana

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  • bioRxiv  ·  February 16, 2026  ·  Preprint

    Privacy-Preserving Pangenome Graphs.

    Jacob Blindenbach, Shaunak Soni, Gamze Gursoy.

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  • bioRxiv  ·  February 16, 2026  ·  Preprint

    Private Information Leakage from Polygenic Risk Scores.

    Kirill Nikitin, Gamze Gursoy.

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  • bioRxiv  ·  February 11, 2026  ·  Preprint

    Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition.

    Mohammadjavad Kahlani, Larry Mesner, Vedavathi Madhu, Lucia Wagner, Kristyna Kupkova, Hannah J Pitas, Ana C Mello, Samuel Ghatan, Tuuli Lappalainen, Neville E Sanjana, John A Morris, View Charles R Farber.

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