Preprint Archives - Page 9 of 24 - New York Genome Center

medRxiv · September 30, 2025 · Preprint

Meta-analysis of genetic regulation of RNA editing in the human brain identifies new genes underlying neurological disease.

Winston H Dredge, Kailash BP, Aline Réal, Benjamin Z Muller, Beomjin Jang, Ting Fu, Hyomin Seo, Hong-Hee Won, Michael S Breen, Xinshu Xiao, David A Knowles, Jack Humphrey, Towfique Raj.

Neuropsychiatric Disease

bioRxiv · October 3, 2025 · Preprint

A conserved logic for the development of cortical layering in tetrapods.

Astrid Deryckere, Saket Choudhary, Connor Lynch, Lian Kirit V. P. Limperis, Pauline Affatato, Jamie Woych, Elias Gumnit, Alonso Ortega Gurrola, Rahul Satija, Christian Mayer, Maria Antonietta Tosches.

Satija Lab

Research Sequencing

bioRxiv · September 29, 2025 · Preprint

Brain Region-Specific Epigenomic Reorganization and Altered Cell States in Alzheimer’s Disease.

Wenliang Wang, Peter Berube, Bing Yang, Rosa Castanon, Anna Bartlett, Kaushik Komandur, Joseph R. Nery, Cesar Barragan, Mia Kenworthy, Cynthia Valadon, Jordan Altshul, Alaina Petrella, Derek Chan, Chumo Chen, Andrea Saldana Acerbo, Jammy Luo, Manya Jain, Eshaan Soma, Huaming Chen, Michelle Liem, Mikayla Marrin, Caz O’Connor, Nathan Zemke, Derek H. Oakley, Bing Ren, Bradley T. Hyman, Joseph R. Ecker.

Ren Lab

Neurodegenerative Disease

medRxiv · September 26, 2025 · Preprint

Mapping genetic effects on splicing in ten thousand post-mortem brain samples reveals novel mediators of neurological disease risk.

Aline Réal, B P Kailash, Winston H Cuddleston, Benjamin Z Muller, Beomjin Jang, Alex Tokolyi, Hong-Hee Won, Jack Humphrey, Towfique Raj, David A Knowles.

Knowles Lab

bioRxiv · September 20, 2025 · Preprint

Mapping transcriptional responses to cellular perturbation dictionaries with RNA fingerprinting.

Isabella N Grabski, Junsuk Lee, John Blair, Carol Dalgarno, Isabella Mascio, Alexandra Bradu, David A Knowles, Rahul Satija.

Satija Lab Knowles Lab

bioRxiv · September 2, 2025 · Preprint

Multiscale Integration of Genetic, Transcriptomic, and Structural Data Identifies Calcium Homeostasis as a Core Mechanism Underlying Neuropsychiatric Disorders.

Sherif Gerges, Nikolaj Catois Straarup, Mohamed A El-Brolosy, F. Kyle Satterstrom, Nolan Kamitaki, Jiayi Yuan, Emi Ling, Raozhou Lin, Melissa Goldman, Tarjinder Singh, Jonathan S. Weissman, Sabina Berretta, Jen Qian Pan, Hilary Finucane, Charlott Stock, Poul Nissen, Steven A. McCarroll, Mark J. Daly.

Singh Lab

Neuropsychiatric Disease

bioRxiv · August 30, 2025 · Preprint

Iterative, multimodal, and scalable single-cell profiling for discovery and characterization of signaling regulators.

John D. Blair, Alexandra Bradu, Carol Dalgarno, Isabella N. Grabski, Rahul Satija.

Satija Lab

bioRxiv · August 29, 2025 · Preprint

Local synthesis of Reticulon-1C lessens the outgrowth of injured axons and Spastin activity.

Alejandro Luarte, Javiera Gallardo, Daniela Corvalan, Ankush Chakraborty, Claudio Gouveia-Roque, Francisca Bertin, Carlos Contreras, Juan Pablo Ramirez, Andre Weber, Waldo Acevedo, Werner Zuschratter, Rodrigo Herrera, Ursula Wyneken, Andrea Paula Lima, Tatiana Adasme, Antonia Figueroa, Carolina Gonzalez, Rodrigo Vergara Sr., Christian Gonzalez-Billault, Jorge Toledo Sr., Ulrich Hengst, Andres Couve.

Phatnani Lab

bioRxiv · August 27, 2025 · Preprint

Genetics-to-structure multiscale analysis identifies disrupted calcium homeostasis as a mechanism of psychiatric disease.

Sherif Gerges, Nikolaj Catois Straarup, Mohamed A El-Brolosy, F. Kyle Satterstrom, Nolan Kamitaki, Jiayi Yuan, Emi Ling, Raozhou Lin, Melissa Goldman, Tarjinder Singh, Jonathan S. Weissman, Sabina Berretta, Jen Qian Pan, Hilary Finucane, Charlott Stock, Poul Nissen, Steven A. McCarroll, Mark J. Daly.

Singh Lab

Neuropsychiatric Disease

ArXiv · August 21, 2025 · Preprint

FAIR sharing of Chromatin Tracing datasets using the newly developed 4DN FISH Omics Format.

Rahi Navelkar, Andrea Cosolo, Bogdan Bintu, Yubao Cheng, Vincent Gardeux, Silvia Gutnik, Taihei Fujimori, Antonina Hafner, Atishay Jay, Bojing Blair Jia, Adam Paul Jussila, Gerard Llimos, Antonios Lioutas, Nuno M C Martins, William J Moore, Yodai Takei, Frances Wong, Kaifu Yang, Huaiying Zhang, Quan Zhu, Magda Bienko, Lacramioara Bintu, Long Cai, Bart Deplancke, Marcelo Nollmann, Susan E Mango, Bing Ren, Peter J Park, Ahilya N Sawh, Andrew Schroeder, Jason R Swedlow, Golnaz Vahedi, Chao-Ting Wu, Sarah Aufmkolk, Alistair N Boettiger, Irene Farabella, Caterina Strambio-De-Castillia, Siyuan Wang.

Ren Lab