Preprint > Page 8
  • bioRxiv  ·  October 30, 2025  ·  Preprint

    Accurately modelling RNase H-mediated antisense oligonucleotide efficacy.

    Barney Hill, Maisie R Jaques, Remya R Nair, Nicola Whiffin, Matthew J. A. Wood, Stephan J Sanders, Peter L Oliver, Alyssa C Hill, Carlo Rinaldi.

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  • bioRxiv  ·  October 27, 2025  ·  Preprint

    Somatic copy number mutations contribute to fitness in transplantation models of spontaneous human breast cancer metastasis

    Hoa Tran, Gurdeep Singh, Hakwoo Lee, Damian Yap, Eric Lee, William Daniels, Farhia Kabeer, Ciara H O’Flanagan, Vinci Au, Michael Van Vliet, Daniel Lai, Elena Zaikova, Sean Beatty, Esther Kong, Shuyu Fan, Jessica Chan, Hoang Quan Dang, Teresa Ruiz de Algaza, Viviana Cerda, Andrew Roth, Samuel Aparicio.

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  • bioRxiv  ·  October 21, 2025  ·  Preprint

    APOBEC3A-Induced DNA Damage Drives Polymerase Theta Dependency and Synthetic Lethality in Cancer.

    Abhishek Bose, Weisi Liu, Paul Yoo, Alina Sami, Michal T Boniecki, Madhura Deshpande, Mohamed Osman, Duy Nguyen, Urko D. Castillo, Paraskevi Giannakakou, Bhavneet Bhinder, William Hooper, Olivier Elemento, Nicolas Robine, Milaid Granadillo Rodrigue, Jeannine Gerhardt, Kent W. Mouw, Linda Chelico, Bishoy M. Faltas.

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  • medRxiv  ·  October 13, 2025  ·  Preprint

    Antidepressants are associated with decreased white blood cell counts beyond the effect of statins in individuals with co-morbid depression and coronary artery disease: A longitudinal analysis in the Vanderbilt University Medical Center and All of Us cohorts.

    Kritika Singh, Freida A Blostein, Quinn S Wells, Emily C Hodges, Nancy J. Cox, Lea Davis.

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  • medRxiv  ·  October 13, 2025  ·  Preprint

    Regulatory landscape of Alzheimer′s disease variants in human microglia.

    Chia-Yi Joy Lee, Ashvin Ravi, Tzu-Chieh Huang, Briana Wyman, Ariana Chriss, Jack Humphrey, David A Knowles, Chris Cotsapas, Laura M Huckins, Towfique Raj, Kristen J Brennand.

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  • bioRxiv  ·  October 13, 2025  ·  Preprint

    Comprehensive benchmarking of somatic single-nucleotide variant and indel detection at ultra-low allele fractions using short- and long-read data.

    Yoo-Jin Jiny Ha, Dominika Maziec, Julia Markowski, Stephanie J Georges, Nancy L Parmalee, Michele Berselli, Tim HH Coorens, Shihua Dong, Stephanie Gardiner, Divya Kalra, Daofeng Li, Benpeng Miao, Rajeeva Musunuri, Liying Xue, Zhi Yu, Kimberly Walker, Lisa Anderson, Natalie YT Au, Carrie Cibulskis, Harsha Doddapaneni, Christopher M Grochowski, Dana M Jensen, Tina Lindsay, Kelsey Loy, Azeet Narayan, Giuseppe Narzisi, Jeffrey Ou, Meranda M Pham, Alexi M Runnels, Andrew B Stergachis, Lila M Sutherlin, Ting Wang, Hu Jin, William C Feng, Yuwei Zhang, Alexander D Veit, Clara TaeHee Kim, Hye-Jung E Chun, Kristin Ardlie, Robert S Fulton, Soren Germer, Richard A Gibbs, Gabor T Marth, James T Bennett, Peter J Park

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  • medRxiv  ·  October 13, 2025  ·  Preprint

    Genomic analyses reveal new insights into Alzheimer’s disease.

    Emil Uffelmann, Douglas P Wightman, Shahram Bahrami, Alexey A Shadrin, Vera Fominykh, Takafumi Ojima, Chenyang Jiang, Christian Benner, Elisa Moreno, Adrian I Campos, Jesper Q Thomassen, Emmanuel Minois-Genin, Hei Man Wu, G. Bragi Walters, Richard Sherva, Tian Lin, Julien Bryois, Kristi Krebs, Marijn Schipper, Akira Narita, Alessandro Serretti, Anja H Simonsen, Anna L van Seumeren, Anne Corbett, Anne-Brita Knapskog, Annette M Hartmann, Anouk den Braber, Argonde C van Harten, Arvid Harder, Arvid Rongve, Bengt O Madsen, Betty M Tijms, Bitten Aagaard, Bjorn Lichtwarck, Bjorn E Kirsebom, Byron Creese, Chandra A Reynolds, Sara Hagg, Ida Karlsson, Christian Erikstrup, Christina Mikkelsen, Clive Ballard, Dag Aarsland, Daichi Shigemizu, Dan Rujescu, Daniel Gudbjartsson, Eivind Aakhus, Erik Sorensen, Eystein Stordal, Flora H Duits, Frank J Wolters, Frederic Blanc, Geert Jan Biessels, Geir Selbaek, Geir Brathen, Gen Tamiya, Gunhild Waldemar, Harro Seelaar, Helga Eyjolfsdottir, Henne Holstege, Henning Bundgaard, Henrik Zetterberg, Henrik Ullum, Ingmar Skoog, Ingrid T Medboen, Ingvild Saltvedt, Ingvild H Feiring, Irena Rektorova, J. Michael Gaziano, Jan Haavik, Jens Hjerling-Leffler, Jiao Luo, Jon Snaedal, Everard GB Vijverberg, Julia M Sealock, Kaj Blennow, Kaja Nordengen, Karin Persson, Katja Scheffler, Koichi Matsuda, Kouichi Ozaki, Lasse Pihlstrom, Lavinia Athanasiu, Lene Palhaugen, Marc Hulsman, Margda Waern, Maria Averina, Marianne Wettergreen, Marta R Moksnes, Martijn Huisman, Masayuki Yamamoto, Mathias Toft, Matthew S Panizzon, Mie Topholm Bruun, Mohsen Ghanbari, Monique Franc, Nancy L Pedersen, Nathaniel Y Bell, Niccolo Tesi, Ole B Pedersen, Oleksandr Frei, Olivier Bousiges, Per Svenningsson, Pieter J Visser, Qingqin S Li, Richard Hauger, Rui Zhang, Shinichi Namba, Sigrid B Sando, Silke Kern, Srdjan Djurovic, Steinunn Thordardottir, Tanya N Phung, Thomas Truelsen, Thomas Werge, Thomas F Hansen, Tomoki Kyosaka, Torgeir Engstad, Tormod Fladby, Victoria Merritt, Sverre Bergh, Wiesje M van der Flier, Rujin Wang, Eli A Stahl, Basavaraj Hooli, 23andMe Research Institute, LifeLines Cohort Study, DBDS Genomic consortium, Regeneron Genetics Center, Penn Medicine Biobank, GHS-RGC DiscovEHR collaboration, Mayo Clinic-RGC Project Generation, Colorado Center for Personalized Medicine – RGC Collaboration, UCLA-RGC ATLAS collaboration, INDIANA-CHALASANI, Mount Sinai Million Health Discoveries Program, Estonian Biobank research team, VA Million Veteran Program, Lea K Davis, Mark W Logue, Kelli Lehto, Anna Zettergren, Ben M Brumpton, Jian Zeng, Peter M Visscher, Paul F O’Reilly, Anubha Mahajan, Manuel Ferreira, Yukinori Okada, Sven J van der Lee, Sisse R Ostrowski, Ruth Frikke-Schmidt, Hreinn Stefansson, Karl Heilbron, Ole A Andreassen, Danielle Posthuma.

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  • bioRxiv  ·  October 13, 2025  ·  Preprint

    Large-scale single-cell phylogenetic mapping of clonal evolution in the human aging esophagus.

    Tamara Prieto, Dennis J Yuan, John Zinno, Clayton Hughes, Nicholas Midler, Sheng Kao, Jani Huuhtanen, Ramya Raviram, Fenia Fotopoulou, Neil Ruthen, Srinivas Rajagopalan, Joshua S Schiffman, Andrew R D Avino, Sang-Ho Yoon, Jesus Sotelo, Nathaniel D Omans, Noelle Wheeler, Alejandro Garces, Barun Pradhan, Alexandre Pellan Cheng, Nicolas Robine, Catherine Potenski, Katharine Godfrey, Nobuyuki Kakiuchi, Akira Yokoyama, Seishi Ogawa, Julian Abrams, Ivan Raimondi, Dan A Landau.

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  • bioRxiv  ·  October 10, 2025  ·  Preprint

    A Physically-Realistic Simulator and Cosine-Based Decoder for MERFISH Spatial Transcriptomics.

    Jenkin Tsui, Naila Adam, Woongcheol Choi, Luna Liu, Cristina Flores, Shadi Ansari, Esther Kong, Yukta Thapliyal, Hakwoo Lee, Shahid Haider, Isaac Von Riedemann, Ciara O’Flanagan, IMAXT Cancer Grand Challenges Consortium, Samuel Aparicio, Andrew Roth.

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  • bioRxiv  ·  October 8, 2025  ·  Preprint

    African Green Monkeys Respond to Synthetic AB Oligomers with Persistent Alzheimers-like Activation.

    Bianca Brown, Xiaoting Li, Monica R Grasty, Isabela Lopez, Sara Dzigurski, Maya Geradi, Matthew Lawrence, John Elsworth, Matthew Lawrence, Micahel Weed, Gamze Gursoy, Andrew David Miranker.

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