Preprint Archives - Page 12 of 24 - New York Genome Center

medRxiv · April 16, 2025 · Preprint

Convex approaches to isolate the shared and distinct genetic structures of subphenotypes in heterogeneous complex traits.

Saikat Banerjee, Shane O’Connell, Sarah Colbert, Niamh Mullins, David A Knowles

bioRxiv · March 19, 2025 · Preprint

Measuring Longitudinal Genome-wide Clonal Evolution of Pediatric Acute Lymphoblastic Leukemia at Single-Cell Resolution.

Yakun Pang, Tamara Prieto, Veronica Gonzalez-Pena, Athena Aragon, Yuntao Xia, Sheng Kao, Sri Rajagopalan, John Zinno, Jean Quentin, Julien Laval, Dennis Yuan, Shulz Shawn, Nathaniel Omans, David Klein, Matthew MacKay, Iwijn De Vlaminck, John Easton, William Evans, Dan A. Landau, Charles Gawad

Landau Lab

Cancer

medRxiv · March 7, 2025 · Preprint

SingleBrain: A Meta-Analysis of Single-Nucleus eQTLs Linking Genetic Risk to Brain Disorders.

Beomjin Jang, Kailash BP, Alex Tokolyi, Winston H. Cuddleston, Ashvin Ravi, Sanghyuk Jung, Tatsuhiko Naito, Beomsu Kim, Min Seo Kim, Minyoung Cho, Mi-So Park, Mikaela Rosen, Joel Blanchard, Jack Humphrey, David A Knowles, Hong-Hee Won, Towfique Raj

Knowles Lab

bioRxiv · March 1, 2025 · Preprint

Multi-sample, multi-platform isoform quantification using empirical Bayes.

Arghamitra Talukder, Shree Thavarekere, Madison Mehlferber, Gloria M Sheynkman, David A Knowles

Knowles Lab

bioRxiv · February 27, 2025 · Preprint

Differential Cellular Mechanisms Underlie Language and Executive Decline in Amyotrophic Lateral Sclerosis.

Joana Petrescu, Claudio Gouveia Roque, Chris Jackson, Aidan Daly, Kristy Kang, Obadele Casel, Mathew Leung, Luke Reilly, Jacqueline Eschbach, Karina McDade, Jenna M Gregory, Colin Smith, Hemali Phatnani

Phatnani Lab

Neurodegenerative Disease

bioRxiv · February 23, 2025 · Preprint

Lancet2: Improved and accelerated somatic variant calling with joint multi-sample local assembly graph.

Rajeeva Lochan Musunuri, Wayne E. Clarke, Bryan Zhu, William Hooper, Timothy Chu, Jennifer Shelton, André Corvelo, Dickson Chung, Shreya Sundar, Adam M Novak, Benedict Paten, Michael C Zody, Nicolas Robine, Giuseppe Narzisi

Computational Biology Lab

bioRxiv · February 20, 2025 · Preprint

Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal Cortex.

Nicholas Sloan, Jason Mares, Aidan C Daly, Lilian Coie, Shaunice Grier, Natalie Barretto, Obadele Casel, Kristy Kang, Chris Jackson, Maria Pedersen, Shruti Khiste, Ben Fullerton, Joana Petrescu, Courteney Mattison, Colin Smith, Yousin Suh, Vilas Menon, Hemali Phatnani.

Phatnani Lab

Neurodegenerative Disease

arXiv · February 12, 2025 · Preprint

PLayer-FL: A Principled Approach to Personalized Layer-wise Cross-Silo Federated Learning.

Ahmed Elhussein, Gamze Gürsoy

medRxiv · January 13, 2025 · Preprint

Regulation of protein abundance in normal human tissues.

Huaying Fang, Lihua Jiang, Felipe da Veiga Leprevost, Ruiqi Jian, Joanne Chan, Dafni Glinos, Tuuli Lappalainen, Alexey I. Nesvizhskii, Alexander P. Reiner, GTEx Consortium, Michael Snyder, Hua Tang

Lappalainen Lab

bioRxiv · January 11, 2025 · Preprint

Enhancer Dynamics and Spatial Organization Drive Anatomically Restricted Cellular States in the Human Spinal Cord.

Elena K. Kandror, Anqi Wang, Mathieu Carriere, Alexis Peterson, Will Liao, Andreas Tjärnberg, Jun Hou Fung, Krishnaa T. Mahbubani, Jackson Loper, William Pangburn, Yuchen Xu, Kourosh Saeb-Parsy, Raul Rabadan, Tom Maniatis, Abbas H. Rizvi

Maniatis Lab