Genomic Technologies

The NYGC’s faculty, staff scientists, and research partners are focused on advancing the development and deployment of novel genomic technologies, including molecular diagnostic testing, liquid biopsy, single-cell analysis, CRISPR gene editing, spatial transcriptomics, and other laboratory computational methods.

 

In 2020, the Center for Integrated Cellular Analysis was established at the NYGC. Funded through the Centers of Excellence in Genomic Science program of the National Human Genome Research Institute, the mission of the Center is to develop a comprehensive suite of technologies and analytical methods to measure and integrate the molecular and environmental determinants of cellular identity. This will address critical challenges in data integration, and produce software, protocols, and strategies. The Center represents a collaboration between six institutions across NYC, and will disseminate technologies, protocols, and software that will be applicable to diverse biological systems. To learn more about the investigators, projects, and educational opportunities, please visit the center website: www.multimodalintegration.org.

 

ECCITE-seq SHOWCASE: For illustration and photo descriptions and a video with the scientists, click here.

The NYGC’s Technology Innovation Lab is a dedicated incubator within the NYGC comprised of a multidisciplinary team in which staff scientists and faculty, as well as many research collaborators, can explore and test breakthrough genomic tools and ideas. Working in collaboration with NYGC Core Faculty Members Neville Sanjana, PhD, and Rahul Satija, PhD, and NYGC member institutions, NYGC’s Technology Innovation Lab, led by Peter Smibert, PhD, recently created Cell Hashing and ECCITE-seq, two extensions for use with CITE-seq, the powerful single-cell analysis technology first developed by NYGC scientists in 2017.

The NYGC’s Enabling Technology Scientific Working Group, led by NYGC Senior Scientific Director of Cancer Genomics Samuel Aparicio, PhD, brings together researchers from our Institutional Founding Members, NYGC faculty, senior faculty, NYGC technology development and computational scientists, and affiliate members to build collaborative initiatives in single cell and spatial transcriptomics and share new technologies with the scientific community to advance precision medicine.