• Molecular Psychiatry  ·  November 28, 2025

    3D genetic architecture of schizophrenia risk across three neuronal subtypes.

    Samuel K. Powell, Will Liao, Sadaf Ghorbani, Raymond Rigat, Callan O’Shea, Sarah Kammourh, Rahat Elahi, Dana Infante, PJ Michael Deans, Derek J. Le, Poonam Agarwal, Wei Qiang Seow, Novin Balafkan, Kevin C. Wang, Schahram Akbarian, Kristen J. Brennand

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  • Npj Breast Cancer  ·  November 27, 2025

    Functional and clinical significance of the RNA m6A methyltransferase complex in breast cancer.

    Anna E. Harris, Jennifer Lothion-Roy, Rachel L. Thompson, Maria Haque, Corinne L. Woodcock, Mansour A. Alsaleem, Alexander Dean, Yousif Kariri, Michael S. Toss, Lorraine J. Gudas, Andrew R. Green, Cinzia Allegrucci, Melissa B. Davis, Sheeba Irshad, Kyong-Hwa Park, Srinivasan Madhusudan, Rupert G. Fray, Jennie N. Jeyapalan, Catrin S. Rutland, Emad A. Rakha, Nigel P. Mongan

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  • Nature Genetics  ·  November 27, 2025

    Passenger mutations link cellular origin and transcriptional identity in human lung adenocarcinomas.

    Sukanya Panja, Padmaja Mantri, Kofi Ennu Johnson, Juan Sebastian Andrade-Martinez, Soo-Ryum Yang, Aditya Deshpande, Huasong Tian, Shaham Beg, Kentaro Ohara, Alessandro Leal, Joel Rosiene, Marlon Stoeckius, Peter Smibert, William D. Travis, Juan Miguel Mosquera, Paz Polak, Marcin Imieliński

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  • Molecular Psychiatry  ·  November 25, 2025

    Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health.

    Hayley H. A. Thorpe, Renata B. Cupertino, Shreya Reddy Pakala, Pierre Fontanillas, Mariela V. Jennings, Jane Yang, John J. Meredith, Tiffany Greenwood, Sevim B. Bianchi, Laura Vilar-Ribó & Maria Niarchou, on behalf of the 23andMe Research Team, Sarah L. Elson, Trey Ideker, Lea K. Davis, James MacKillop, Harriet deWit, Daniel E. Gustavson, Travis T. Mallard, Abraham A. Palmer & Sandra Sanchez-Roige

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  • bioRxiv  ·  November 25, 2025  ·  Preprint

    Transcriptome-wide profiling of alternative splicing regulators with CRISPore-seq.

    Simon Müller, Nathanael Andrews, Rachel E. Yan, Akash Sookdeo, Wells H. Burrell, Xiaoguang Dai, Priyesh Rughani, Zharko Daniloski, Sissel Juul, Neville E. Sanjana

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  • Nature Methods  ·  November 24, 2025

    From slices to deep dishes: spatial transcriptomics and translatomics of thick tissue blocks.

    Maroš Pleška, Sanja Vickovic

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  • medRxiv  ·  November 22, 2025  ·  Preprint

    Biobank-scale Bayesian TWAS reveals splicing-mediated mechanisms of complex disease.

    Alex Tokolyi, Saikat Banerjee, David A Knowles

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  • bioRxiv  ·  November 10, 2025  ·  Preprint

    Disruption of Cell-Type-Specific Molecular Programs of Medium Spiny Neurons in Autism.

    Guohua Yuan, Varun Suresh, Emilie Wigdor, Yuhan Hao, Rachel Leonard, Marilyn Steyert, Michael Griffiths, Clements Evans, Narjes Rohani, Jakob Weiss, Frederick H. Lassen, Nicole Schafer, Shan Dong, Duncan S. Palmer, Stephan J. Sanders, Tomasz J. Nowakowski.

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  • Nature Biomedical Engineering  ·  November 9, 2025

    Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders.

    Junhao Wen, Ioanna Skampardoni, Ye Ella Tian, Zhijian Yang, Yuhan Cui, Guray Erus, Gyujoon Hwang, Erdem Varol, Aleix Boquet-Pujadas, Ganesh B. Chand, Ilya M. Nasrallah, Theodore D. Satterthwaite, Haochang Shou, Li Shen, Arthur W. Toga, Andrew Zalesky & Christos Davatzikos

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  • bioRxiv  ·  November 5, 2025  ·  Preprint

    Distinct patterns of de novo coding variants contribute to Tourette Syndrome etiology.

    Lingyu Zhan, Dongmei Yu, Franjo Ivankovic, Maria Niarchou, Laura Domenech-Salgado, Cathy L. Barr, Fortu Benarroch, Cathy L. Budman, Danielle C. Cath, Nelson B. Freimer, Helena Garrido, Marco A. Grados, Varda Gross-Tsur, Luis Herrera-Amighetti, Robert A. King, Roger Kurlan, James F. Leckman, Gholson J. Lyon, William M. McMahon, David L. Pauls, Yehuda Pollak, Mary M. Robertson, Roxana Romero, Guy A. Rouleau, Paul Sandor, Harvey S. Singer, Paola Giusti-Rodriguez, Lea K. Davis, Carol A. Mathews, Jeremiah M. Scharf, Roel A. Ophoff

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  • bioRxiv  ·  November 5, 2025  ·  Preprint

    Large-scale discovery of neural enhancers for cis-regulation therapies.

    Troy A. McDiarmid, Nicholas F. Page, Florence M. Chardon, Riza M. Daza, George T. Chen, Michael Kosicki, Lucas M. James, Hannah C. Nourie, Dianne Laboy-Cintron, Arthur S. Lee, Paula Vij, Diego Calderon, Jean-Benoit Lalanne, Beth K. Martin, Kyle Fink, Michael E. Talkowski, Alysson R. Muotri, Benjamin D. Philpot, Len A. Pennacchio, Daniel H. Geschwind, Stephan J. Sanders, Nadav Ahituv, Jay Shendure.

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  • medRxiv  ·  November 5, 2025  ·  Preprint

    Genome-wide association studies of binge-eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes.

    Jet D Termorshuizen, Helena L Davies, Sang-Hyuck Lee, Jessica K Dennis, Christopher Hübel, Jessica S Johnson, Yi Lu, Melissa A Munn-Chernoff, Triinu Peters, Baiyu Qi, Katherine E Schaumberg, Rebecca H Signer, Karanvir Singh, Abigail R ter Kuile, Laura M Thornton, Jiayi Xu, Shuyang Yao, Zeynep Yilmaz, Ruyue Zhang, Johan Zvrskovec, Mohamed Abdulkadir, Ziada Ayorech, Elizabeth C Corfield, Alexandra Havdahl, Kristi Krebs, Taralynn M Mack, Maria Niarchou, Teemu Palviainen, Julia M Sealock, Jessica H Baker, Andrew W Bergen, Andreas Birgegård, Vesna Boraska Perica, Katharina Bühren, Roland Burghardt, Matteo Cassina, Enrico Collantoni, James J Crowley, Unna N Danner, Franziska Degenhardt, Janiece E DeSocio, Christian Dina, Monika Dmitrzak-Węglarz, Laramie E Duncan, Karin M Egberts, Lenka Foretova, Ina Giegling, Fragiskos Gonidakis, Scott D Gordon, Jakob Grove, Sébastien Guillaume, Jerry D Guintivano, Annette M Hartmann, Konstantinos Hatzikotoulas, Stefan Herms, Hartmut Imgart, Susana Jiménez-Murcia, Antonio Julià, Gursharan Kalsi, Deborah Kaminská, Leila J Karhunen, Hannah Kennedy, Kirsty M Kiezebrink, Theresa Kolb, Janne T Larsen, Dong Li, Lisa Lilenfeld, Mario Maj, Morten Mattingsdal, Paolo Meneguzzo, Allison L Miller, Karen S Mitchell, Alessio Maria Monteleone, Catherine M Olsen, Leonid Padyukov, Richard Parker, Michaela Pettie, Dalila Pinto, Anu Raevuori, Samuli Ripatti, Marion E Roberts, Paolo Santonastaso, Androula Savva, Ulrike H Schmidt, Alexandra Schosser, Jochen Seitz, Lenka LS Slachtova, Agnieszka Slopien, Sandro Sorbi, Peter S Straub, Jin P Szatkiewicz, Friederike I Tam, Elena Tenconi, Alfonso Tortorella, Artemis Tsitsika, Annemarie A van Elburg, Gudrun Wagner, Hunna J Watson, Roger AH Adan, Lars Alfredsson, Ole A Andreassen, Helga Ask, Anders Børglum, Harry A Brandt, David Collier, Steven Crawford, Scott Crow, Lea K Davis, Martina de Zwaan, George Dedoussis, Danielle M Dick, Stefan Ehrlich, Xavier Estivill, Angela Favaro, Fernando Fernández-Aranda, Krista Fischer, Andreas J Forstner, Philip Gorwood, Hakon Hakonarson, Johannes Hebebrand, Beate Herpertz-Dahlmann, Anke Hinney, James I Hudson, Craig Johnson, Jennifer Jordan, Allan S Kaplan, Jaakko Kaprio, Andreas FK Karwautz, Martien JH Kas, Walter H Kaye, James L Kennedy, Martin A Kennedy, Anna Keski-Rahkonen, Youl-Ri Kim, Kelly L Klump, Mikael Landén, Stéphanie Le Hellard, Kelli Lehto, Qingqin S Li, Jolanta Lissowska, Jurjen J Luykx, Sarah L Maguire, Nicholas G Martin, Manuel Mattheisen, Sarah E Medland, Philip Mehler, Nadia Micali, James E Mitchell, Palmiero Monteleone, Preben Bo Mortensen, Benedetta Nacmias, Roel A Ophoff, Hana Papezova, Nancy L Pedersen, Liselotte V Petersen, Luisa S Rajcsanyi, Nicolas Ramoz, Ted Reichborn-Kjennerud, Valdo Ricca, Stephan Ripke, Dan Rujescu, Filip Rybakowski, Stephen W Scherer, Margarita CT Slof-Op ‘t Landt, Howard Steiger, Patrick F Sullivan, Beata Świątkowska, Eric F van Furth, Tracey D Wade, Thomas Werge, David C Whiteman, D. Blake Woodside, Ya-Ke Wu, Stephan Zipfel, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Estonian Biobank (EstBB), Cynthia M Bulik, Laura M Huckins, Gerome Breen, Jonathan RI Coleman.

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  • bioRxiv  ·  November 3, 2025  ·  Preprint

    A comprehensive view of somatic mosaicism by single-cell DNA analysis.

    Lovelace J Luquette, Tim H H Coorens, Abhiram Natu, Milovan Suvakov, Ann Caplin, Mee Sook Jun, Alisa Mo, Joe Pelt, Lisa Anderson, Michele Berselli, Sravya Bhamidipati, Thomas Blanchard, Joseph Brew, Hye-Jung E Chun, Hyunbin Chun, Mrunal K Dehankar, William C Feng, Rob Furatero, Christopher M Grochowski, Eric Ho, Yeongjun Jang, Kavya Kottapalli, M Kathryn Leonard, Nam Seop Lim, Tina Lindsay, Sarah Nicholson, Ivan Raimondi, Alexi Runnels, Constantijn Scharlee, JaeEun Shin, Alexander D Veit, Melissa VonDran, Yifan Wang, Dennis J Yuan, Yifan Zhao; SMaHT Single Cell Focus Group, Thomas J Bell, Kristin Ardlie, Harsha Doddapaneni, Robert Fulton, Soren Germer, Dan Landau, Ji Won Oh, Peter J Park, Flora M Vaccarino, Christopher Walsh, Alexej Abyzov.

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  • Cold Spring Harbor Perspectives in Biology  ·  November 3, 2025

    Glia in Neurodegenerative Disease.

    Gerard Crowley, David Attwell, Hemali Phatnani, Harald Sontheimer, and Soyon Hong.

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  • bioRxiv  ·  October 30, 2025  ·  Preprint

    Accurately modelling RNase H-mediated antisense oligonucleotide efficacy.

    Barney Hill, Maisie R Jaques, Remya R Nair, Nicola Whiffin, Matthew J. A. Wood, Stephan J Sanders, Peter L Oliver, Alyssa C Hill, Carlo Rinaldi.

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  • American Journal of Psychiatry  ·  October 29, 2025

    Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment.

    Travis T Mallard, Justin D Tubbs, Mariela Jennings, Yingzhe Zhang, Daniel E Gustavson, Andrew D Grotzinger, Margaret L Westwater, Camille M Williams, Rebecca G Fortgang; 23andMe Research Team; Sarah L Elson, Pierre Fontanillas, Lea K Davis, Armin Raznahan, Elliot M Tucker-Drob, Karmel W Choi, Tian Ge, Jordan W Smoller, Abraham A Palmer, Sandra Sanchez-Roige.

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  • bioRxiv  ·  October 27, 2025  ·  Preprint

    Somatic copy number mutations contribute to fitness in transplantation models of spontaneous human breast cancer metastasis

    Hoa Tran, Gurdeep Singh, Hakwoo Lee, Damian Yap, Eric Lee, William Daniels, Farhia Kabeer, Ciara H O’Flanagan, Vinci Au, Michael Van Vliet, Daniel Lai, Elena Zaikova, Sean Beatty, Esther Kong, Shuyu Fan, Jessica Chan, Hoang Quan Dang, Teresa Ruiz de Algaza, Viviana Cerda, Andrew Roth, Samuel Aparicio.

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  • Proceedings of the National Academy of Sciences of the United States of America  ·  October 28, 2025

    Genetic regulation of the estrogen receptor and inherited predisposition to breast cancer.

    Sarah B Pierce, Hannah Kortbawi, Suleyman Gulsuner, Jessica B Mandell, Ming K Lee, Tom Walsh, Mary-Claire King.

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  • bioRxiv  ·  October 21, 2025  ·  Preprint

    APOBEC3A-Induced DNA Damage Drives Polymerase Theta Dependency and Synthetic Lethality in Cancer.

    Abhishek Bose, Weisi Liu, Paul Yoo, Alina Sami, Michal T Boniecki, Madhura Deshpande, Mohamed Osman, Duy Nguyen, Urko D. Castillo, Paraskevi Giannakakou, Bhavneet Bhinder, William Hooper, Olivier Elemento, Nicolas Robine, Milaid Granadillo Rodrigue, Jeannine Gerhardt, Kent W. Mouw, Linda Chelico, Bishoy M. Faltas.

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  • Nature Neuroscience  ·  October 21, 2025

    TDP-43 loss induces cryptic polyadenylation in ALS/FTD.

    Sam Bryce-Smith, Anna-Leigh Brown, Max Z. Y. J. Chien, Dario Dattilo, Puja R. Mehta, Francesca Mattedi, Simone Barattucci, Alla Mikheenko, Matteo Zanovello, Flaminia Pellegrini, Sara Emad El-Agamy, Matthew Yome, Sarah E. Hill, Yue A. Qi, Kai Sun, Eugeni Ryadnov, Yixuan Wan, NYGC ALS Consortium, Jose Norberto S. Vargas, Nicol Birsa, Towfique Raj, Jack Humphrey, Matthew Keuss, Oscar G. Wilkins, Michael Ward, Maria Secrier & Pietro Fratta.

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  • medRxiv  ·  October 13, 2025  ·  Preprint

    Antidepressants are associated with decreased white blood cell counts beyond the effect of statins in individuals with co-morbid depression and coronary artery disease: A longitudinal analysis in the Vanderbilt University Medical Center and All of Us cohorts.

    Kritika Singh, Freida A Blostein, Quinn S Wells, Emily C Hodges, Nancy J. Cox, Lea Davis.

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