• bioRxiv  ·  February 4, 2026  ·  Preprint

    Single-cell Multiome Analysis of Chromatin State and Transcriptome in the Human Basal Ganglia.

    Lei Chang, Kai Li, Yang Xie, Guojie Zhong, Jonathan A. Rink, Cindy Tatiana Baez-Becerra, Audrey Lie, Hannah S Indralingam, Keyi Dong, Timothy Loe, Zhaoning Wang, Songpeng Zu, Joseph Colin Kern, Zoey Zhao, Eric Boone, Jesus Flores, Alexander Monell, Jacqueline Olness, Cesar Barragan, Emma Osgood, William Owens, Natalie Schenker-Ahmed, Wenjin Zhang, Di Liu, Ariana S. Barcoma, Jackson K. Willier, Kyle W. Knutson, Kaitlyn G. Russo, Jiayi Liu, Silvia Cho, Jessica Arzavala, Carissa K. Young, Guha V. Sundaram, Austin C. Manning, Yareli Sanchez, Aleksandra Bikkina, Jillian Berry, Xiaomeng Gao, Carolyn OConnor, Michelle Liem, Mikayla V. Marrin, Cynthia Rose, Shane N. Alt, Chenxu Zhu, Nathan R Zemke, Wubin Ding, Amit Klein, Yuanyuan Fu, Nelson Johansen, Trygve E. Bakken, Rebecca D. Hodge, C. Dirk Keene, Ed S. Lein, Daofeng Li, Quan Zhu, Ting Wang, Xiangmin Xu, Joseph R. Ecker, M. Margarita Behrens, Bing Ren

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  • Nature Genetics  ·  February 3, 2026

    Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.

    Nora I. Strom, Brad Verhulst, Silviu-Alin Bacanu, Rosa Cheesman, Kirstin L. Purves, Hüseyin Gedik, Brittany L. Mitchell, Alex S. Kwong, Annika B. Faucon, Kritika Singh, Sarah Medland, Lucia Colodro-Conde, Kristi Krebs, Per Hoffmann, Stefan Herms, Jan Gehlen, Stephan Ripke, Swapnil Awasthi, Teemu Palviainen, Elisa M. Tasanko, Roseann E. Peterson, Daniel E. Adkins, Andrey A. Shabalin, Mark J. Adams, Matthew H. Iveson, Archie Campbell, Laurent F. Thomas, Bendik S. Winsvold, Ole Kristian Drange, Sigrid Børte, Abigail R. ter Kuile, Joonas Naamanka, Tan-Hoang Nguyen, Sandra M. Meier, Elizabeth C. Corfield, Laurie Hannigan, Daniel F. Levey, Darina Czamara, Heike Weber, Karmel W. Choi, Giorgio Pistis, Baptiste Couvy-Duchesne, Sandra Van der Auwera, Alexander Teumer, Robert Karlsson, Miguel Garcia-Argibay, Donghyung Lee, Rujia Wang, Ottar Bjerkeset, Eystein Stordal, Julia Bäckman, Giovanni A. Salum, Clement C. Zai, James L. Kennedy, Gwyneth Zai, Arun K. Tiwari, Stefanie Heilmann-Heimbach, Börge Schmidt, Jaakko Kaprio, Martin M. Kennedy, Joseph Boden, Alexandra Havdahl, Christel M. Middeldorp, Fabiana L. Lopes, Nirmala Akula, Francis J. McMahon, Elisabeth B. Binder, Lydia Fehm, Andreas Ströhle, Enrique Castelao, Henning Tiemeier, Dan J. Stein, David Whiteman, Catherine Olsen, Zachary Fuller, Xin Wang, Naomi R. Wray, Enda M. Byrne, Glyn Lewis, Nicholas J. Timpson, Lea K. Davis, Ian B. Hickie, Nathan A. Gillespie, Lili Milani, Johannes Schumacher, David P. Woldbye, Andreas J. Forstner, Markus M. Nöthen, Iiris Hovatta, John Horwood, William E. Copeland, Hermine H. Maes, Andrew M. McIntosh, Ole A. Andreassen, John-Anker Zwart, Ole Mors, Anders D. Børglum, Preben B. Mortensen, Helga Ask, Ted Reichborn-Kjennerud, Jackob M. Najman, Murray B. Stein, Joel Gelernter, Yuri Milaneschi, Brenda W. Penninx, Dorret I. Boomsma, Eduard Maron, Angelika Erhardt-Lehmann, Christian Rück, Tilo T. Kircher, Christiane A. Melzig, Georg W. Alpers, Volker Arolt, Katharina Domschke, Jordan W. Smoller, Martin Preisig, Nicholas G. Martin, Michelle K. Lupton, Annemarie I. Luik, Andreas Reif, Hans J. Grabe, Henrik Larsson, Patrik K. Magnusson, Albertine J. Oldehinkel, Catharina A. Hartman, Gerome Breen, Anna R. Docherty, Hilary Coon, Rupert Conrad, Kelli Lehto, Veterans Affairs Million Veteran Program, FinnGen, 23andMe Research Team, Jürgen Deckert, Thalia C. Eley, Manuel Mattheisen & John M. Hettema

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  • bioRxiv  ·  February 3, 2026  ·  Preprint

    Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Programs in the Human Brain.

    Yang Xie, Lei Chang, Guojie Zhong, Jonathan A. Rink, Tatiana Baez-Becerra, Ethan Armand, Wubin Ding, Kai Li, Eric Boone, Audrey Lie, Hannah S Indralingam, Keyi Dong, Timothy Loe, Bohan Huang, Zhaoning Wang, Ariana S. Barcoma, Jackson K. Willier, Kyle W. Knutson, Jiayi Liu, Silvia Cho, Stella Cao, Kaitlyn G. Russo, Carissa K. Young, Jessica Arzavala, Yareli Sanchez, Aleksandra Bikkina, Natalie Schenker-Ahmed, Colin Kern, Zoey Zhao, Amit Klein, Jesus Flores, Chu-Yi Tai, Jacqueline Olness, Alexander Monell, Siavash Moghadami, Cesar Barragan, Chumo Chen, William Owens, Carolyn OConnor, Michelle Liem, Mikayla V. Marrin, Cynthia Rose, Shane N. Alt, Nora Emerson, Julia Osteen, Jacinta Lucero, Daofeng Li, Rebecca D. Hodge, Ting Wang, C. Dirk Keene, Xiangming Xu, Quan Zhu, Joseph R. Ecker, M. Margarita Behrens, Bing Ren

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  • bioRxiv  ·  January 29, 2026  ·  Preprint

    An Integrated Single-Cell and Epigenomic Resource for Comparative Analysis of the Basal Ganglia..

    Wenjin Zhang, Wubin Ding, Kai Li, Lei Chang, Amit Klein, Cindy Tatiana Baez-Becerra, Jonathan A. Rink, Anna Bartlett, Huaming Chen, Natalie Schenker, Nelson Johansen, Tyler Mollenkopf, Yuanyuan Fu, Xie Yang, Shane Liu, Chanrung Seng, Benpeng Miao, Tianjie Liu, Quan Zhu, Rebecca D. Hodge, Trygve E. Bakken, Ed S. Lein, Michael Hawrylycz, Xiangmin Xu, M. Margarita Behrens, Bing Ren, Joseph R. Ecker, Ting Wang, Daofeng Li.

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  • bioRxiv  ·  January 29, 2026  ·  Preprint

    SUMO2 Deletion Changes Chromatin Accessibility and Enhances Cytotoxic T Cell Activation and Tumor Infiltration

    Neranjan Tharuka Mohottige Don, Dai-Hua Chen, Maria Luisa J Amaral, Tianchen Ren, Yixuan Kuang, Shih-Ting Huang, Nikhil Chilakapati, Bing Ren, Stephen P, Schoenberger, Ye Zheng, Yuan Chen

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  • bioRxiv  ·  January 24, 2026  ·  Preprint

    A Manifold-Based Measure of Transcriptional Entropy for Quantifying Aging in Single Cells.

    Yilin Yang, Paul R. Hess, Sijia Huang, Marcos G. Teneche, Hanzhi Wang, Karl N. Miller, Andrew E. Davis, Charlene Miciano, Kelly Yichen Li, Sainath Mamde, Kevin Yip, Bing Ren, Qian Yang, Elizabeth Smoot, Allen Wang, Bradley Johnson, Parker Wilson, Peter D. Adams, Nancy R. Zhang

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  • Cell Genomics  ·  January 22, 2026

    Uncovering the signatures of aging and senescence in the human dorsolateral prefrontal cortex.

    Nicholas X Sloan, Jason Mares, Aidan C Daly, Shaunice Grier, Imdadul Haq, Christopher A Jackson, Natalie Barretto, Obadele Casel, Kristy Kang, Shruti Khiste, Kennedy Harris, Jacqueline Eschbach, Benjamin T Fullerton, Courteney Mattison, Brhan Gebremedhin, Joana Petrescu, Lilian Coie, Maria Hauge Pedersen, Ke Zhang, Jian Shu, Andrew F Teich, Hasini Reddy, Colin P Smith, Yousin Suh, Vilas Menon, Hemali Phatnani

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  • Addict Biol.  ·  January 31, 2026

    Optimizing Control Definitions in Opioid Use Disorder Genetic Research Using Electronic Health Records.

    Maria Niarchou, Ellen L Tsai, Mariela V Jennings, Annika Faucon, Hyunjoon Lee, Kritika Singh, Justin D Tubbs, Panos Roussos, Tian Ge, Richard C Crist, Rachel Vickers-Smith, Howard Edenberg, Amy Moore, Bradley T Webb, Eric O Johnson; PsycheMERGE Substance Use Disorder Workgroup; Rachel L Kember, Jordan W Smoller, Lea K Davis, Brandon J Coombes, Georgios Voloudakis, David Burstein, Travis T Mallard, Vanessa Troiani, Sandra Sanchez-Roige.

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  • Life Science Alliance  ·  January 16, 2026

    Reticulon-1 synthesis controls outgrowth and microtubule dynamics in injured cortical axons.

    Alejandro Luarte, Javiera Gallardo, Daniela Corvalán, Ankush Chakraborty, Cláudio Gouveia Roque, Francisca Bertin, Carlos Contreras, Juan Pablo Ramírez, André Weber, Waldo Acevedo, Werner Zuschratter,Rodrigo Herrera-Molina, Úrsula Wyneken, Andrea Paula-Lima, Tatiana Adasme-Rocha, Jorge Toledo, Rodrigo Vergara, Antonia Figueroa, Carolina González, Christian González-Billault, Ulrich Hengst, Andrés Couve

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  • medRxiv  ·  January 16, 2026  ·  Preprint

    Multi-molecular scores map process-specific polygenic diabetes risk to atherosclerosis, cardiometabolic diseases, and vascular complications.

    Hui Li, Jakub Morze, Martin Adiels, Joel Kullberg, Jordi Merino, Magdalena Sevilla-Gonzalez, Göran Bergström, Marju Orho-Melander, Stefan Söderberg, Carl Johan Östgren, Tuuli Lappalainen, Tove Fall, Miriam S Udler, Ida Häggström, Clemens Wittenbecher

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  • JAMA Network Open  ·  January 15, 2026

    Polygenic Risk, Trait Variables, and External Stressors in Fatal and Nonfatal Suicidal Behavior.

    Min Ji Kim, Hanga Galfalvy, Tarjinder Singh, J John Mann

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  • Genome Biology  ·  January 15, 2026

    Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants.

    Wonji Kim, Xiaowei Hu, Kangjin Kim, Sung Chun, Peter Orchard, Dandi Qiao, Ingo Ruczinski, Aabida Saferali, Francois Aguet, Lucinda Antonacci-Fulton, Pallavi P. Balte, Traci M. Bartz, Wardatul Jannat Anamika, Xiaobo Zhou, JunYi Duan, Jennifer A. Brody, Brian E. Cade, Martha L. Daviglus, Harshavadran Doddapaneni, Shannon Dugan-Perez, Susan K. Dutcher, Christian D. Frazar, Stacey B. Gabriel, Sina A. Gharib, Namrata Gupta, Brian D. Hobbs, Silva Kasela, Laura R. Loehr, Ginger A. Metcalf, Donna M. Muzny, Elizabeth C. Oelsner, Laura J. Rasmussen-Torvik, Colleen M. Sitlani, Joshua Smith, Tamar Sofer, Hanfei Xu, Bing Yu, David Zhang, John Ziniti, R. Graham Barr, April P. Carson, Myriam Fornage, Lifang Hou, Ravi Kalhan, Robert Kaplan, Tuuli Lappalainen, Stephanie J. London, Alanna C. Morrison, George T. O’Connor, Bruce M. Psaty, Laura M. Raffield, Susan Redline, Stephen S. Rich, Jerome I. Rotter, Edwin K. Silverman, Ani Manichaikul & Michael H. Cho

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  • Nature  ·  January 14, 2026

    Microbiota-induced T cell plasticity enables immune-mediated tumour control.

    Tariq A. Najar, Yuan Hao, Yuhan Hao, Gabriela Romero-Meza, Alexandra Dolynuk, Emma Almo & Dan R. Littman

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  • American Journal of Medical Genetics Part B: Neuropsychiatric Genetics  ·  January 13, 2026

    Are There Causal Associations Between Obsessive-Compulsive Disorder and Cardiometabolic Phenotypes? A Genetic Correlation and Bi-Directional Mendelian Randomization Study.

    Robyn E Wootton, James J Crowley, Josep Pol-Fuster, Anna Holmberg, Christian Rück; Obsessive‐Compulsive Disorder Working Group of the Psychiatric Genomics Consortium (Lea K. Davis), David Mataix-Cols, Lorena Fernández de la Cruz

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  • bioRxiv  ·  January 9, 2026  ·  Preprint

    TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons, crypTEs, in iPSC derived neurons and ALS/FTD patient tissues.

    Isobel Bolger, Regina Shaw, Oliver H Tam, Claudio Gouveia Roque, Christopher A Jackson, Kathryn O’neill, NYGC ALS Consortium, Colin Smith, Hemali Phatnani, Karthick Natarajan, Molly Gale Hammell.

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  • Cancer Cell  ·  January 12, 2026

    Characterization of a pathogenic subpopulation of human glioma associated macrophages linked to glioma progression.

    Kenny Kwok Hei Yu, Zaki Abou-Mrad, Kristof Törkenczy, Isabell Schulze, Jennifer Gantchev, Gerard Baquer, Kelsey Hopland, Evan D Bander, Umberto Tosi, Cameron Brennan, Nelson S Moss, Pierre-Jacques Hamard, Richard Koche, Caleb Lareau, Nathalie Y R Agar, Taha Merghoub, Viviane Tabar

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  • American Society for Microbiology  ·  January 8, 2026

    Case-control and genomic epidemiology characterization of SARS-CoV-2 breakthrough infections during the Delta-to-Omicron transition.

    Erin Yuan, Chelsea L. Hansen, Sana Tamim, Samia Kanwar, David J. Spiro, Refugio Gonzalez-Losa, Laura Conde-Ferraez, Pilar Granja-Pérez, Salha Villanueva-Jorge, Irma López-Martínez, Gisela Barrea-Badillo, André Corvelo, Samantha Fennessey, Michael C. Zody, Guadalupe Ayora-Talavera, Nidia S. Trovao

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  • Nature Biotechnology  ·  January 5, 2026

    Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM.

    Jiayu Su, Yiming Qu, Megan Schertzer, Haochen Yang, Jiahao Jiang, Tenzin Lhakhang, Theodore M. Nelson, Stella Park, Qiliang Lai, Xi Fu, Seung-won Choi, David A. Knowles & Raul Rabadan

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  • Cancer Discovery  ·  December 31, 2025

    Genotype-to-phenotype mapping of somatic clonal mosaicism via single-cell co-capture of DNA mutations and mRNA transcripts.

    Dennis J Yuan, John Zinno, Theo Botella, Dalia Dhingra, Shu Wang, Allegra G Hawkins, Ariel Swett, Jesus Sotelo, Ramya Raviram, Clayton Hughes, Catherine Potenski, Katharine D Godfrey, Kara M Ainsworth, Shuzhen Xu, Jianwen Que, Julian A Abrams, Akira Yokoyama, Nobuyuki Kakiuchi, Seishi Ogawa, Dan A Landau.

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