• bioRxiv  ·  February 16, 2026  ·  Preprint

    Privacy-Preserving Pangenome Graphs.

    Jacob Blindenbach, Shaunak Soni, Gamze Gursoy.

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  • bioRxiv  ·  February 16, 2026  ·  Preprint

    Private Information Leakage from Polygenic Risk Scores.

    Kirill Nikitin, Gamze Gursoy.

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  • Prog Retin Eye Res.  ·  February 16, 2026

    Age-related macular degeneration and cerebral amyloid angiopathy have similar pathologies from cholesterol-APOE-amyloid-β-complement mediated inflammation.

    Whitney Stuard Sambhariya, Catherine Bowes Rickman, Patricia A D’Amore, Giulia Corradetti, Gregory S Hageman, Gareth R Howell, Olivia J Marola, Hemali Phatnani, Nancy J Philp, Debasish Sinha, Christopher B Toomey, Faith Stone, Charles Eberhart, James T Handa.

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  • Curr Opin Genet Dev .  ·  February 17, 2026

    The role of cohesin and DNA loop extrusion in the generation of single neuron identity.

    Lea Kiefer, Tom Maniatis, Daniele Canzio.

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  • bioRxiv  ·  February 17, 2026  ·  Preprint

    hoodscanR: profiling single-cell neighborhoods in spatial transcriptomics data.

    Ning Liu, Jarryd Martin, Dharmesh D Bhuva, Jinjin Chen, Mengbo Li, Samuel C Lee, Malvika Kharbanda, Jinming Cheng, Ahmed Mohamed, Arutha Kulasinghe, Yunshun Chen, Chin Wee Tan, Fuyi Li, Jose M Polo, Melissa J Davis

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  • bioRxiv  ·  February 11, 2026  ·  Preprint

    Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition.

    Mohammadjavad Kahlani, Larry Mesner, Vedavathi Madhu, Lucia Wagner, Kristyna Kupkova, Hannah J Pitas, Ana C Mello, Samuel Ghatan, Tuuli Lappalainen, Neville E Sanjana, John A Morris, View Charles R Farber.

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  • bioRxiv  ·  February 12, 2026  ·  Preprint

    Evolution of oncogene amplification across 86,000 cancer cell genomes.

    Jake June-Koo Lee, Sohrab Salehi, Matthew A. Myers, Marc J. Williams, Melissa A. Yao, Duaa H. Al-Rawi, Jin Lee, Eric G. Sun, Kerstin Thol, Seongmin Choi, Eliyahu Havasov, Asher Preska Steinberg, Michelle Wu, Nicole Rusk, Caitlin Timmons, Cheryl Zi Jin Phua, Stephen Martis, Neeman Mohibullah, Parvathy Manoj, Esther Redin, Álvaro Quintanal-Villalonga, Pedram Razavi, Samuel Aparicio, Natasha Rekhtman, Viviane Tabar, Mark M. Awad, Helena A. Yu, Kenny Kwok Hei Yu, Andrea Ventura, Andrew McPherson, Charles M. Rudin, Sohrab P. Shah.

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  • bioRxiv  ·  February 12, 2026  ·  Preprint

    Genome-wide single-cell perturbation screens with VIPerturb-seq.

    Alexandra Bradu, John D. Blair, Isabella N. Grabski, Isabella Mascio, Junsuk Lee, Cecilia McCormick, Rahul Satija.

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  • bioRxiv  ·  February 12, 2026  ·  Preprint

    A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia.

    Wubin Ding, Amit Klein, Cindy Tatiana Báez-Becerra, Jonathan A. Rink, Anna Bartlett, Qiurui Zeng, Ruoxuan Wang, Rosa Gomez Castanon, Joseph R. Nery, Emma Osgood, William Owens, Alaina Petrella, Chumo Chen, Andrea Saldana Acerbo, Ariana S. Barcoma, Jiayi Liu, Kaitlyn G. Russo, Kyle W. Knutson, Carissa K. Young, Jackson K. Willier, Ceasar Barragan, Jessica Arzavala, Silvia Cho, Jordan Altshul, Derek Chan, Eshaan Soma, Jammy Luo, Manya Jain, Sarah Velazquez, Natalie Schenker-Ahmed, Guha V. Sundaram, Austin C. Manning, Yareli Sanchez, Aleksandra Bikkina, Shuai Fu, Carolyn O’Connor, Michelle Liem, Mikayla V. Marrin, Cynthia Rose, Shane N. Alt, Jillian Berry, Colin Kern, Eric Boone, Wei Tian, Yue Wu, Manoj Hariharan, Yuanyuan Fu, Yang Xie, Kai Li, Lei Chang, Wenjin Zhang, Huamin Chen, Nelson Johansen, Zoey Zhao, Jesus Flores, Chu-Yi Tai, Jacquelin Olness, Quan Zhu, Rebecca D. Hodge, Trygve E. Bakken, Ed S. Lein, Daofeng Li, Ting Wang, Xiangmin Xu, Bing Ren, Maria Margarita Behrens, Joseph R. Ecker.

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  • Neuron  ·  February 12, 2026

    Enhancer dynamics and cellular architecture in the human spinal cord.

    Elena K Kandror, Mathieu Carriere, Alexis Peterson, Will Liao, Andreas Tjärnberg, Jun Hou Fung, Krishnaa T Mahbubani, Jackson Loper, William Pangburn, Yuchen Xu, Kourosh Saeb-Parsy, Tom Maniatis, Abbas H Rizvi

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  • bioRxiv  ·  February 6, 2026  ·  Preprint

    SenNet Portal: Build, Optimization and Usage.

    Katy Borner, Philip D. Blood, Jonathan C. Silverstein, Matthew Ruffalo, Rahul Satija, Nils Gehlenborg, Brendan Honick, Andreas Bueckle, \Yashvardhan Jain, Danial Qaurooni, Bill Shirey, Max Sibilla, Kay Metis, Joe Bisciotti, Richard S. Morgan, David Betancur, Geoffrey Ryan Sablosky, Morgan L Turner, So-Jin Kim, Patty J Lee, Josh Bartz, Sergii Domanskyi, Samuel T. Peters, Archibald Enninful, Negin Farzad, Rong Fan, SenNet Team, Bruce W. Herr II.

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  • Genet. Med.  ·  February 3, 2026

    Interventional Genomics: Bridging Germline Diagnosis and Therapeutic Action.

    Petros Giannikopoulos, Marlen C Lauffer, Christian R Marshall, Gregory Costain, Zhiyv Niu, David Bick, Wei Shen, Matthew C Hiemenz, Sucheta Bhatt, Wayne Grody, Vaidehi Jobanputra; Medical Genome Initiative.

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  • bioRxiv  ·  February 7, 2026  ·  Preprint

    Integrative Single-Cell Epigenomic Atlas Annotates the Regulatory Genome of the Adult Mouse Brain.

    Zhaoning Wang, Songpeng Zu, Ethan J Armand, Timothy H Loe, Jonathan A Rink, Wanying Wu, Yang Xie, Lei Chang, Chenxu Zhu, Nicholas D Johnson, Jasper Lee, Jackson K Willier, Silvia Cho, Stella Cao, Ariana S Barcoma, Nora Emerson, Hanqing Liu, Kangli Wang, Zane A Gibbs, Xiaomeng Gao, Sunan Xu, David Guo, Zhuowen Tu, Yang E Li, Joseph R Ecker, Maria Margarita Behrens, Bing Ren.

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  • medRxiv  ·  February 6, 2026  ·  Preprint

    Transcriptomic profiling uncovers mis-splicing and gene fusions in amyotrophic lateral sclerosis.

    Huilin Xu, Tiziana Petrozziello, Adel Boudi, Shota Shibata, Sommer S. Huntress, Alireza Shahryari, Xuefang Zhao, Maheswaran Kesavan, Eric J. Granucci, Ayleen L. Castillo Torres, Ranee Zara B. Monsanto, John Lemanski, Bimal Jana, Celin E.F. De Esch, Merit E. Cudkowicz, James D. Berry, NYGC ALS Consortium, Harrison Brand, Michael E. Talkowski, Ricardo Mouro Pinto, Dadi Gao, Ghazaleh Sadri-Vakili

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  • bioRxiv  ·  February 4, 2026  ·  Preprint

    Single-cell Multiome Analysis of Chromatin State and Transcriptome in the Human Basal Ganglia.

    Lei Chang, Kai Li, Yang Xie, Guojie Zhong, Jonathan A. Rink, Cindy Tatiana Baez-Becerra, Audrey Lie, Hannah S Indralingam, Keyi Dong, Timothy Loe, Zhaoning Wang, Songpeng Zu, Joseph Colin Kern, Zoey Zhao, Eric Boone, Jesus Flores, Alexander Monell, Jacqueline Olness, Cesar Barragan, Emma Osgood, William Owens, Natalie Schenker-Ahmed, Wenjin Zhang, Di Liu, Ariana S. Barcoma, Jackson K. Willier, Kyle W. Knutson, Kaitlyn G. Russo, Jiayi Liu, Silvia Cho, Jessica Arzavala, Carissa K. Young, Guha V. Sundaram, Austin C. Manning, Yareli Sanchez, Aleksandra Bikkina, Jillian Berry, Xiaomeng Gao, Carolyn OConnor, Michelle Liem, Mikayla V. Marrin, Cynthia Rose, Shane N. Alt, Chenxu Zhu, Nathan R Zemke, Wubin Ding, Amit Klein, Yuanyuan Fu, Nelson Johansen, Trygve E. Bakken, Rebecca D. Hodge, C. Dirk Keene, Ed S. Lein, Daofeng Li, Quan Zhu, Ting Wang, Xiangmin Xu, Joseph R. Ecker, M. Margarita Behrens, Bing Ren

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  • Nature Genetics  ·  February 3, 2026

    Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.

    Nora I. Strom, Brad Verhulst, Silviu-Alin Bacanu, Rosa Cheesman, Kirstin L. Purves, Hüseyin Gedik, Brittany L. Mitchell, Alex S. Kwong, Annika B. Faucon, Kritika Singh, Sarah Medland, Lucia Colodro-Conde, Kristi Krebs, Per Hoffmann, Stefan Herms, Jan Gehlen, Stephan Ripke, Swapnil Awasthi, Teemu Palviainen, Elisa M. Tasanko, Roseann E. Peterson, Daniel E. Adkins, Andrey A. Shabalin, Mark J. Adams, Matthew H. Iveson, Archie Campbell, Laurent F. Thomas, Bendik S. Winsvold, Ole Kristian Drange, Sigrid Børte, Abigail R. ter Kuile, Joonas Naamanka, Tan-Hoang Nguyen, Sandra M. Meier, Elizabeth C. Corfield, Laurie Hannigan, Daniel F. Levey, Darina Czamara, Heike Weber, Karmel W. Choi, Giorgio Pistis, Baptiste Couvy-Duchesne, Sandra Van der Auwera, Alexander Teumer, Robert Karlsson, Miguel Garcia-Argibay, Donghyung Lee, Rujia Wang, Ottar Bjerkeset, Eystein Stordal, Julia Bäckman, Giovanni A. Salum, Clement C. Zai, James L. Kennedy, Gwyneth Zai, Arun K. Tiwari, Stefanie Heilmann-Heimbach, Börge Schmidt, Jaakko Kaprio, Martin M. Kennedy, Joseph Boden, Alexandra Havdahl, Christel M. Middeldorp, Fabiana L. Lopes, Nirmala Akula, Francis J. McMahon, Elisabeth B. Binder, Lydia Fehm, Andreas Ströhle, Enrique Castelao, Henning Tiemeier, Dan J. Stein, David Whiteman, Catherine Olsen, Zachary Fuller, Xin Wang, Naomi R. Wray, Enda M. Byrne, Glyn Lewis, Nicholas J. Timpson, Lea K. Davis, Ian B. Hickie, Nathan A. Gillespie, Lili Milani, Johannes Schumacher, David P. Woldbye, Andreas J. Forstner, Markus M. Nöthen, Iiris Hovatta, John Horwood, William E. Copeland, Hermine H. Maes, Andrew M. McIntosh, Ole A. Andreassen, John-Anker Zwart, Ole Mors, Anders D. Børglum, Preben B. Mortensen, Helga Ask, Ted Reichborn-Kjennerud, Jackob M. Najman, Murray B. Stein, Joel Gelernter, Yuri Milaneschi, Brenda W. Penninx, Dorret I. Boomsma, Eduard Maron, Angelika Erhardt-Lehmann, Christian Rück, Tilo T. Kircher, Christiane A. Melzig, Georg W. Alpers, Volker Arolt, Katharina Domschke, Jordan W. Smoller, Martin Preisig, Nicholas G. Martin, Michelle K. Lupton, Annemarie I. Luik, Andreas Reif, Hans J. Grabe, Henrik Larsson, Patrik K. Magnusson, Albertine J. Oldehinkel, Catharina A. Hartman, Gerome Breen, Anna R. Docherty, Hilary Coon, Rupert Conrad, Kelli Lehto, Veterans Affairs Million Veteran Program, FinnGen, 23andMe Research Team, Jürgen Deckert, Thalia C. Eley, Manuel Mattheisen & John M. Hettema

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  • bioRxiv  ·  February 3, 2026  ·  Preprint

    Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Programs in the Human Brain.

    Yang Xie, Lei Chang, Guojie Zhong, Jonathan A. Rink, Tatiana Baez-Becerra, Ethan Armand, Wubin Ding, Kai Li, Eric Boone, Audrey Lie, Hannah S Indralingam, Keyi Dong, Timothy Loe, Bohan Huang, Zhaoning Wang, Ariana S. Barcoma, Jackson K. Willier, Kyle W. Knutson, Jiayi Liu, Silvia Cho, Stella Cao, Kaitlyn G. Russo, Carissa K. Young, Jessica Arzavala, Yareli Sanchez, Aleksandra Bikkina, Natalie Schenker-Ahmed, Colin Kern, Zoey Zhao, Amit Klein, Jesus Flores, Chu-Yi Tai, Jacqueline Olness, Alexander Monell, Siavash Moghadami, Cesar Barragan, Chumo Chen, William Owens, Carolyn OConnor, Michelle Liem, Mikayla V. Marrin, Cynthia Rose, Shane N. Alt, Nora Emerson, Julia Osteen, Jacinta Lucero, Daofeng Li, Rebecca D. Hodge, Ting Wang, C. Dirk Keene, Xiangming Xu, Quan Zhu, Joseph R. Ecker, M. Margarita Behrens, Bing Ren

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  • bioRxiv  ·  January 29, 2026  ·  Preprint

    An Integrated Single-Cell and Epigenomic Resource for Comparative Analysis of the Basal Ganglia.

    Wenjin Zhang, Wubin Ding, Kai Li, Lei Chang, Amit Klein, Cindy Tatiana Baez-Becerra, Jonathan A. Rink, Anna Bartlett, Huaming Chen, Natalie Schenker, Nelson Johansen, Tyler Mollenkopf, Yuanyuan Fu, Xie Yang, Shane Liu, Chanrung Seng, Benpeng Miao, Tianjie Liu, Quan Zhu, Rebecca D. Hodge, Trygve E. Bakken, Ed S. Lein, Michael Hawrylycz, Xiangmin Xu, M. Margarita Behrens, Bing Ren, Joseph R. Ecker, Ting Wang, Daofeng Li.

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  • medRxiv  ·  January 30, 2026  ·  Preprint

    Integrating multi-omic QTLs and predictive models reveals regulatory architectures at immune related GWAS loci in CD4+ T cells.

    Marliette R Matos, Samuel Ghatan, Sean Bankier, Taylor V Thompson, Kassidy Lundy-Perez, Masako Suzuki, Reanna Doña-Termine, Jacob Stauber, David Reynolds, Kathleen Rosales, Anthony Griffen, Mariko Isshiki, Danny Simpson, Nathanael Andrews, Omar Ahmed, Samantha Gold, Sophia R Ostrowiak, Srilakshmi Raj, Sofiya Milman, Tuuli Lappalainen, John M Greally

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  • bioRxiv  ·  January 29, 2026  ·  Preprint

    SUMO2 Deletion Changes Chromatin Accessibility and Enhances Cytotoxic T Cell Activation and Tumor Infiltration

    Neranjan Tharuka Mohottige Don, Dai-Hua Chen, Maria Luisa J Amaral, Tianchen Ren, Yixuan Kuang, Shih-Ting Huang, Nikhil Chilakapati, Bing Ren, Stephen P, Schoenberger, Ye Zheng, Yuan Chen

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