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Lappalainen Lab

Tuuli Lappalainen’s lab studies functional genetic variation in human populations. It is particularly interested in regulatory variation affecting the transcriptome, as well as cellular mechanisms underlying genetic associations to disease. The lab integrates computational analysis of genomic and transcriptomic data with population genetic and experimental analysis.

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Tuuli Lappalainen, PhD

Senior Associate Faculty Member, NYGC
Director, National Genomics Infrastructure, SciLifeLab; Professor, KTH School of Engineering Sciences in Chemistry, Biotechnology and Health; Former Assistant Professor, Department of Systems Biology, Columbia University

About Dr. Lappalainen

Latest News & Publications

medRxiv · April 29, 2026 · Preprint

The New York Genome Center ALS Consortium resource combines postmortem tissue transcriptomics with whole genome sequencing to empower biological discovery.

Knowles Lab Lappalainen Lab Phatnani Lab Neurodegenerative Disease ALS Consortium Computational Biology Lab
The American Journal of Human Genetics · April 2, 2026

Multi-ancestry transcriptome prediction with functionally informed variants in TOPMed MESA improves performance of transcriptome-wide association studies.

Lappalainen Lab
bioRxiv · February 11, 2026 · Preprint

Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition.

Sanjana Lab Lappalainen Lab

March 25, 2026
Tuuli Lappalainen, PhD Receives Prestigious European Society of Human Genetics Award

Lappalainen Lab

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Lappalainen Lab

Tuuli Lappalainen, PhD

Latest News & Publications

The New York Genome Center ALS Consortium resource combines postmortem tissue transcriptomics with whole genome sequencing to empower biological discovery.

Multi-ancestry transcriptome prediction with functionally informed variants in TOPMed MESA improves performance of transcriptome-wide association studies.

Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition.

Tuuli Lappalainen, PhD Receives Prestigious European Society of Human Genetics Award

Support The Lappalainen Lab

Join Our Team