Knowles Lab
The Knowles Lab opened in January 2019 at the New York Genome Center, jointly with Columbia University. The lab’s research involves the development of novel machine learning methods and their application to data analysis challenges in genomics with the aim to better understand the role of transcriptomic dysregulation across the spectrum from rare to common genetic disease. Another key area of research focus is better characterization of the genetic and environmental factors contributing to mRNA expression and splicing variation. The lab works with diverse research groups at the NYGC and beyond in collecting large-scale genomics datasets in the context of neurological disease and developing novel genomic technologies, including single cell methods, forward genetic screens and long-read transcriptomics.
David A. Knowles, PhD
