Publications - New York Genome Center

Nature 464, 768—772 · January 30, 2015

Understanding mechanisms underlying human gene expression variation with RNA sequencing.

Pickrell, J.K., Marioni, J.C., Pai, A.A., Degner, J.F., Engelhardt, B.E., Nkadori, E., Veyrieras, J.-B., Stephens, M., Gilad, Y., Pritchard, J.K.

Proc Natl Acad Sci U S A 93, 4529-4536. PMC39311 · January 30, 2015

Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain.

Darnell, R. B.

Nat Med 4, 1321-1324 · January 30, 2015

Tumor-specific killer cells in paraneoplastic cerebellar degeneration.

Albert, M. L., Darnell, J. C., Bender, A., Francisco, L. M., Bhardwaj, N. & Darnell, R. B.

Science 302, 1212-1215 · January 30, 2015

CLIP identifies Nova-regulated RNA networks in the brain.

Ule, J., Jensen, K. B., Ruggiu, M., Mele, A., Ule, A. & Darnell, R. B.

N Engl J Med 349, 1543-1554 · January 30, 2015

Paraneoplastic syndromes involving the nervous system.

Darnell, R. B. & Posner, J. B.

Prostate Cancer Prostatic Dis 7, 63-72 · January 30, 2015

Effective antigen cross-presentation by prostate cancer patients’ dendritic cells: implications for prostate cancer immunotherapy.

Orange, D. E., Jegathesan, M., Blachere, N. E., Frank, M. O., Scher, H. I., Albert, M. L. & Darnell, R. B.

Nature 456, 464-469 · January 30, 2015

HITS-CLIP yields genome-wide insights into brain alternative RNA processing.

Licatalosi, D. D., Mele, A., Fak, J. J., Ule, J., Kayikci, M., Chi, S. W., Clark, T. A., Schweitzer, A. C., Blume, J. E., Wang, X., Darnell, J. C. & Darnell, R. B.

Nature 460, 479-486. PMC2733940 · January 30, 2015

Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.

Chi, S. W., Zang, J. B., Mele, A. & Darnell, R. B.

PLoS One 5. PMC2931687 · January 30, 2015

Harnessing naturally occurring tumor immunity: a clinical vaccine trial in prostate cancer.

Frank, M. O., Kaufman, J., Tian, S., Suarez-Farinas, M., Parveen, S., Blachere, N. E., Morris, M. J., Slovin, S., Scher, H. I., Albert, M. L. & Darnell, R. B.

Wiley Interdiscip Rev RNA 1, 266-286 · January 30, 2015

HITS-CLIP: panoramic views of protein-RNA regulation in living cells.

Darnell, R. B.

Neuron 66, 848-858 · January 30, 2015

Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling.

Yano, M., Hayakawa-Yano, Y., Mele, A. & Darnell, R. B.

Front Neural Circuits 4, 5. PMC2856630 · January 30, 2015

The neuronal splicing factor Nova co-localizes with target RNAs in the dendrite.

Racca, C., Gardiol, A., Eom, T., Ule, J., Triller, A. & Darnell, R. B.

Cell 146, 247-261 · January 30, 2015

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism.

Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y., Mele, A., Fraser, C. E., Stone, E. F., Chen, C., Fak, J. J., Chi, S. W., Licatalosi, D. D., Richter, J. D. & Darnell, R. B.

Genes Dev 26, 1626-1642. PMC3404389 · January 30, 2015

Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.

Licatalosi, D. D., Yano, M., Fak, J. J., Mele, A., Grabinski, S. E., Zhang, C. & Darnell, R. B.

Neuron 75, 1067-1080 · January 30, 2015

Neuronal Elav-like (Hu) Proteins Regulate RNA Splicing and Abundance to Control Glutamate Levels and Neuronal Excitability.

Ince-Dunn, G., Okano, H. J., Jensen, K. B., Park, W. Y., Zhong, R., Ule, J., Mele, A., Fak, J. J., Yang, C., Zhang, C., Yoo, J., Herre, M., Okano, H., Noebels, J. L. & Darnell, R. B.

Cold Spring Harbor Laboratory Press · January 30, 2015

Mapping of in vivo RNA binding sites by UV-crosslinking immuopreciptiation (CLIP).

Green, M. & Sambrook, J. (eds)

Nat Struct Mol Biol 19, 321-327 · January 30, 2015

An alternative mode of microRNA target recognition.

Chi, S. W., Hannon, G. J. & Darnell, R. B.

Neuron 75, 437-450. PMC3418517 · January 30, 2015

Muscleblind-like 2-Mediated Alternative Splicing in the Developing Brain and Dysregulation in Myotonic Dystrophy.

Charizanis, K., Lee, K. Y., Batra, R., Goodwin, M., Zhang, C., Yuan, Y., Shiue, L., Cline, M., Scotti, M. M., Xia, G., Kumar, A., Ashizawa, T., Clark, H. B., Kimura, T., Takahashi, M. P., Fujimura, H., Jinnai, K., Yoshikawa, H., Gomes-Pereira, M., Gourdon, G., Sakai, N., Nishino, S., Foster, T. C., Ares, M. J., Darnell, R. B. & Swanson, M. S.

Elife 2, e00105. PMC3564474 · January 30, 2015

Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo.

Orange, D. E., Blachere, N. E., Fak, J., Parveen, S., Frank, M. O., Herre, M., Tian, S., Monette, S. & Darnell, R. B.

eLIFE 2 · January 30, 2015

NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.

Eom, T., Zhang, C., Wang, H., Lay, K., Fak, J., Noebels, J. L. & Darnell, R. B.

Annu Rev Neurosci, Vol 36 · January 30, 2015

RNA Protein Interaction in Neurons.

Darnell, R. B.

Our Scientific Publications

Understanding mechanisms underlying human gene expression variation with RNA sequencing.

Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain.

Tumor-specific killer cells in paraneoplastic cerebellar degeneration.

CLIP identifies Nova-regulated RNA networks in the brain.

Paraneoplastic syndromes involving the nervous system.

Effective antigen cross-presentation by prostate cancer patients’ dendritic cells: implications for prostate cancer immunotherapy.

HITS-CLIP yields genome-wide insights into brain alternative RNA processing.

Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.

Harnessing naturally occurring tumor immunity: a clinical vaccine trial in prostate cancer.

HITS-CLIP: panoramic views of protein-RNA regulation in living cells.

Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling.

The neuronal splicing factor Nova co-localizes with target RNAs in the dendrite.

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism.

Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.

Neuronal Elav-like (Hu) Proteins Regulate RNA Splicing and Abundance to Control Glutamate Levels and Neuronal Excitability.

Mapping of in vivo RNA binding sites by UV-crosslinking immuopreciptiation (CLIP).

An alternative mode of microRNA target recognition.

Muscleblind-like 2-Mediated Alternative Splicing in the Developing Brain and Dysregulation in Myotonic Dystrophy.

Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo.

NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.

RNA Protein Interaction in Neurons.