Publications

Our Scientific Publications

  • Proc Natl Acad Sci USA  ·  June 15, 2021

    ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy.

    Olivia Harding, Chantell S Evans, Junqiang Ye, Jonah Cheung, Tom Maniatis, Erika L F Holzbaur

    Maniatis Lab Neurodegenerative Disease
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  • Seminars in Cancer Biology  ·  June 10, 2021

    Analytical Demands to Use Whole-Genome Sequencing in Precision Oncology.

    Meggendorfer M, Jobanputra V, Wrzeszczynski KO, Roepman P, de Bruijn E, Cuppen E, Buttner R, Caldas C, Grimmond S, Mullighan CG, Elemento O, Rosenquist R, Schuh A, Haferlach T.
    Cancer Clinical Genetics
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  • The Lancet Psychiatry  ·  June 8, 2021

    The epidemiology of psychiatric disorders in Africa: a scoping review.

    M Claire Greene, PhD, Tenzin Yangchen, MA, Prof Thomas Lehner, PhD, Prof Patrick F Sullivan, MD, Prof Carlos N Pato, MD Prof Andrew McIntosh, MD

    Neuropsychiatric Disease
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  • bioRxiv  ·  June 5, 2021  ·  Preprint

    Non-Coding Genetic Analysis Implicates Interleukin 18 Receptor Accessory Protein 3′UTR in Amyotrophic Lateral Sclerosis

    Chen Eitan, Elad Barkan, Tsviya Olender, Kristel R. van Eijk, Matthieu Moisse, Sali M. K. Farhan, Aviad Siany, Shu-Ting Hung, Nancy Yacovzada, Johnathan Cooper-Knock, Kevin P. Kenna, Rick A. A. van der Spek, William Sproviero, Ahmad Al Khleifat, Alfredo Iacoangeli, Aleksey Shatunov Shatunov, Ashley R. Jones, Elik Chapnik, Daphna Rothschild, Omer Weissbrod, Sebastian Werneburg, Dorothy P. Schafer, Robert H. Brown Jr., Pamela J. Shaw, Philip Van Damme, Leonard H. van den Berg, Hemali P. Phatnani, Eran Segal, Justin K. Ichida, Ammar Al-Chalabi, Jan H. Veldink, Project MinE ALS Sequencing Consortium, NYGC ALS Consortium, Eran Hornstein

    Phatnani Lab Neurodegenerative Disease
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  • Nature Biotechnology  ·  June 3, 2021

    Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells.

    Eleni P. Mimitou, Caleb A. Lareau, Kelvin Y. Chen, Andre L. Zorzetto-Fernandes, Yuhan Hao, Yusuke Takeshima, Wendy Luo, Tse-Shun Huang, Bertrand Z. Yeung, Efthymia Papalexi, Pratiksha I. Thakore, Tatsuya Kibayashi, James Badger Wing, Mayu Hata, Rahul Satija, Kristopher L. Nazor, Shimon Sakaguchi, Leif S. Ludwig, Vijay G. Sankaran, Aviv Regev & Peter Smibert

    Satija Lab Biology, Genomics & Technology
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  • medRxiv  ·  June 2, 2021  ·  Preprint

    IL10RB as a key regulator of COVID-19 host susceptibility and severity.

    Georgios Voloudakis, Gabriel Hoffman, Sanan Venkatesh,Kyung Min Lee, Kristina Dobrindt, James Vicari, Wen Zhang,Noam D. Beckmann, Shan Jiang, Daisy Hoagland, Jiantao Bian, Lina Gao, André Corvelo, Kelly Cho, Jennifer S. Lee, Sudha K. Iyengar,Shiuh Wen Luoh, Schahram Akbarian, Robert Striker, Themistocles L. Assimes, Eric E. Schadt, Miriam Merad, Benjamin R. tenOever, Alexander W. Charney, Kristen J. Brennand, Julie A. Lynch, John F. Fullard, Panos Roussos

    Biology, Genomics & Technology Computational Biology Lab
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  • Cell  ·  May 31, 2021

    Integrated analysis of multimodal single-cell data.

    Yuhan Hao, Stephanie Hao, Erica Andersen-Nissen, William M. Mauck, Shiwei Zheng, Andrew Butler, Maddie Jane Lee, Aaron J. Wilk, Charlotte Darby, Michael Zagar, Paul Hoffman, Marlon Stoeckius, Efthymia Papalexi, Eleni P. Mimitou, Jaison Jain, Avi Srivastava, Tim Stuart, Lamar B. Fleming, Bertrand Yeung, Angela J. Rogers, Juliana M. McElrath, Catherine A. Blish, Raphael Gottardo, Peter Smibert, Rahul Satija

    Satija Lab Biology, Genomics & Technology
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  • Molecular Cell  ·  May 20, 2021

    Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.

    Hogg SJ, Motorna O, Cluse LA, Johanson TM, Coughlan HD, Raviram R, Myers RM, Costacurta M, Todorovski I, Pijpers L, Bjelosevic S, Williams T, Huskins SN, Kearney CJ, Devlin JR, Fan Z, Jabbari JS, Martin BP, Fareh M, Kelly MJ, Dupéré-Richer D, Sandow JJ, Feran B, Knight D, Khong T, Spencer A, Harrison SJ, Gregory G, Wickramasinghe VO, Webb AI, Taberlay PC, Bromberg KD, Lai A, Papenfuss AT, Smyth GK, Allan RS, Licht JD, Landau DA, Abdel-Wahab O, Shortt J, Vervoort SJ, Johnstone RW.

    Landau Lab Cancer Biology, Genomics & Technology
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  • Emerging Microbes & Infections  ·  May 12, 2021

    A Novel Diagnostic Test to Screen SARS-CoV-2 Variants Containing E484K and N501Y Mutations.

    Yanan Zhao, Annie Lee, Kaelea Composto, Marcus H Cunninghan, Jose R Mediavilla, Samantha Fennessey, André Corvelo, Kar Fai Chow, Michael C Zody, Liang Chen, Barry N. Kreiswirth, David S Perlin

    Biology, Genomics & Technology Computational Biology Lab Research Sequencing
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  • Cancer Discovery  ·  May 10, 2021

    Discovery of candidate DNA methylation cancer driver genes.

    Heng Pan, Loic Renaud, Ronan Chaligne, Johannes Bloehdorn, Eugen Tausch, Daniel Mertens, Anna Maria Fink, Kirsten Fischer, Chao Zhang, Doron Betel, Andreas Gnirke, Marcin Imielinski, Jerome Moreaux, Michael Hallek, Alexander Meissner, Stephan Stilgenbauer, Catherine J. Wu, Olivier Elemento and Dan A. Landau
    Cancer Biology, Genomics & Technology
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  • Nature Immunology  ·  May 6, 2021

    A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness.

    Kerstin B. Kaufmann, Andy G. X. Zeng, Etienne Coyaud, Laura Garcia-Prat, Efthymia Papalexi, Alex Murison, Estelle M. N. Laurent, Michelle Chan-Seng-Yue, Olga I. Gan, Kristele Pan, Jessica McLeod, Héléna Boutzen, Sasan Zandi, Shin-ichiro Takayanagi, Rahul Satija, Brian Raught, Stephanie Z. Xie & John E. Dick

    Satija Lab Biology, Genomics & Technology
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  • Genome Research  ·  May 4, 2021

    The genomic basis of evolutionary differentiation among honey bees.

    Fouks B, Brand P, Nguyen HN, Herman J, Camara F, Ence D, Hagen D, Hoff KJ, Nachweide S, Romoth L, Walden KK, Guigo R, Stanke M, Narzisi G, Yandell M, Robertson HM, Koeniger N, Chantawannakul P, Schatz MC, Worley KC, Robinson GE, Elsik CG, Rueppell
    Computational Biology Lab
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  • medRxiv  ·  May 3, 2021  ·  Preprint

    Rapid Identification and Phenotyping of Nonalcoholic Fatty Liver Disease Patients Using an Automated Algorithmic Approach in Diverse, Urban Healthcare Systems.

    Anna Okula Basile, Anurag Verma, Leigh Ann Tang, Marina Serper, Andrew Scanga, Ava Farrell, Brittney M Destin, Rotonya M Carr, Anuli Anyanwu-Ofili, Gunaretnam Rajagopal, Abraham Krikhely, Marc Bessler, Muredach P. Reilly, Marylyn D. Ritchie, Joshua Denny, Nicholas P Tatonetti, Julia Wattacheril

    Biology, Genomics & Technology Computational Biology Lab
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  • Nature Biotechnology  ·  April 29, 2021

    Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens.

    Noa Liscovitch-Brauer, Antonino Montalbano, Jiale Deng, Alejandro Méndez-Mancilla, Hans-Hermann Wessels, Nicholas G. Moss, Chia-Yu Kung, Akash Sookdeo, Xinyi Guo, Evan Geller, Suma Jaini, Peter Smibert & Neville E. Sanjana

    Sanjana Lab Cancer Biology, Genomics & Technology
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  • bioRxiv  ·  April 23, 2021  ·  Preprint

    Cell environment shapes TDP-43 function: implications in neuronal and muscle disease.

    Urša Šušnjar, Neva Škrabar, Anna-Leigh Brown, Yasmine Abbassi, NYGC ALS Consortium, Hemali Phatnani, Andrea Cortese, Cristina Cereda, Enrico Bugiardini, Rosanna Cardani, Giovanni Meola, Michela Ripolone, Maurizio Moggio, Maurizio Romano, Maria Secrier, Pietro Fratta, Emanuele Buratti

    Phatnani Lab Neurodegenerative Disease
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  • J Hered  ·  April 22, 2021

    Feather Gene Expression Elucidates the Developmental Basis of Plumage Iridescence in African Starlings.

    Rubenstein DR, Corvelo A, MacManes MD, Maia R, Narzisi G, Rousaki A, Vandenabeele P, Shawkey MD, Solomon J.
    Biology, Genomics & Technology Computational Biology Lab
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  • Genome Medicine  ·  April 21, 2021

    Genetic and non-genetic factors affecting the expression of COVID-19 relevant genes in the large airway epithelium.

    Silva Kasela, Victor E Ortega, Molly Martorella, Suresh Garudadri, Jenna Nguyen, Elizabeth Ampleford, Anu Pasanen, Srilaxmi Nerella, Kristina L Buschur, Igor Z Barjaktarevic, R Graham Barr, Eugene R Bleecker, Russell P Bowler, Alejandro P Comellas, Christopher B Cooper, David J Couper, Gerard J Criner, Jeffrey L Curtis, MeiLan K Han, Nadia N Hansel, Eric A Hoffman, Robert J Kaner, Jerry A Krishnan, Fernando J Martinez, Merry-Lynn N McDonald, Deborah A Meyers, Robert Paine III, Stephen P Peters, Mario Castro, Loren C Denlinger, Serpil C Erzurum, John V Fahy, Elliot Israel, Nizar N Jarjour, Bruce D Levy, Xingnan Li, Wendy C Moore, Sally E Wenzel, Joe Zein, NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Charles Langelier, Prescott G Woodruff, Tuuli Lappalainen, Stephanie A Christenson

    Lappalainen Lab Biology, Genomics & Technology
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