• bioRxiv  ·  December 26, 2025  ·  Preprint

    UC Irvine Brain Initiative Cell Atlas Network (BICAN) Brain Procurement Program for the Center for Multiomic Human Brain Cell Atlas Project.

    Xiangmin Xu, Jillian V Berry, Bryan M Tran, Ginny Wu, Zhiqun Tan, Elizabeth Mendoza, Miyoung Kim, Zeynep Arat, Payton Sho Huai Lin, Lorena Valenzuela, Todd C Holmes, Anna Virovka, Melina Thaxton, Matthew Nguyen, Sabrina Stein, Victoria Raha Sigaroudi, Alexis De La Rosa, Brianna Gawronski, Justine Silva, Lourdes Gonzalez, Sierra Wright, Kevin Wood, Gabriel K Hui, Darren Anousaya, Vishwaas Reddy Gangeddula, Noah Gama, Jasmine Gama, Thomas Gross, Blynn Bunney, Richard Stein, Pedro Adolfo Sequeira, Firoza Mamdani, Preston Cartagena, William E Bunney, Jerry Lou, Hannah Lui Park, Amanda Wilson, H. Mark Brooks, Virginia Allhusen, John Crawford, Jason M Knight, Bing Ren, Joseph Ecker, M. Margarita Behrens, C Dirk Keene, Craig Stark, Elizabeth Head, William Yong, Edwin Monuki

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  • Signal Transduction and Targeted Therapy  ·  December 25, 2025

    Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer.

    Nadine Bley, Alexander Rausch, Simon Müller, Theresa Simon, Markus Glaß, Danny Misiak, Laura Schian, Lara Meret Peters, Mohammad Dipto, Ali Hmedat, Bianca Busch, Annekatrin Schott, Marcell Lederer, Alice Wedler, Robin Benedikt Rolnik, Hend Elrewany, Ehab Ghazy, Wolfgang Sippl, Martina Vetter, Markus Wallwiener & Stefan Hüttelmaier

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  • bioRxiv  ·  December 25, 2025  ·  Preprint

    A Retinoic Acid Autoregulatory Loop Governing Prefrontal-Motor Arealization.

    Lin Yang, Mikihito Shibata, Saejeong Park, Yuting Liu, Iva Salamon, Jia Liu, Suel-Kee Kim, Akemi Shibata, Ashley Deveau-French, Xoel Mato Blanco, Suxia Bai, Timothy Nottoli, Xiaojun Xing, Narjes Rohani, Stephan J Sanders, Rothem Kovner, Kartik Pattabiraman, Nenad Sestan

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  • Alzheimer's & Dementia  ·  December 24, 2025

    Sex-specific patterns of a machine learning-derived Alzheimer’s brain atrophy imaging signature in participants without diagnosed cognitive impairment: A multi-cohort study.

    Filippos Anagnostakis, Mehrshad Saadatinia, Sarah Ko, Erdem Varol, Despina Kontos, Ajay Gupta, Adam Brickman, Li Shen, Guray Erus, Haochang Shou, Ye Ella Tian, Andrew Zalesky, Christos Davatzikos, Susan M. Resnick, Junhao Wen

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  • bioRxiv  ·  December 20, 2025  ·  Preprint

    Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling and associates with impaired neighboring T cell function..

    Armin Gandhi, Kathry Lande, Yichen Li, Filipe A. Hoffman, Michael LaPorte, Shirong Tan, Garrett Evensen, Benji Portillo, Marcos Garcia Teneche, Rouven Arnold, Adarsh Rajesh, Jessica Proulx, Shanshan Yin, Aaron P Havas, Charlene Miciano, Qian Yang, Elizabeth Smoot, Sainath Mamde, Andrew Davis, Kevin Yip, Allen Wang, Bing Ren, April Williams, Susan Kaech, Peter D. Adams.

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  • J Gerontol A Biol Sci Med Sci.  ·  December 22, 2025

    The Sixth Annual Symposium of the Midwest Aging Consortium.

    Ines Sturmlechner, Sarah A Ashiqueali, Hélène Martini, Karla Valdivieso, Ana Catarina Franco, Prashanth Guthikonda, Andrew J Dosch, Luis I Prieto, Niels C Asmussen, Amanda S Latham, James T Redden, Ethan A Leitschuh, Douglas G Mashek, João F Passos, Jhonny Rodriguez-Lopez, T Blake Monroe, David A Bernlohr, Paul D Robbins, Bailey A Knopf, Dudley W Lamming, Matthew J Johnston, Holly M Brown-Borg, Spencer A Tye, Timothy W Rhoads, David M Gate, Bennett G Childs, Darren J Baker, Xinna Li, In Hwa Jang, Christina D Camell, Zachary Miller, Hemali Phatnani, Adam R Konopka, Andrew J Haak, Natalia Vanegas-Avendano, Ramya N Akula, Ajinkya R Limkar, William A Ricke, Scott F Leiser, Jacinta Correia, Hua Bai, Szczepan Olszewski, Kenneth L Seldeen, G R Scott Budinger, Luisa C Morales-Nebreda, Deborah R Winter, Shelly K Mccrady-Spitzer, Rozalyn M Anderson, Maria M Mihaylova, Mauricio Rojas, Ana L Mora, Nathan K Lebrasseur, Marissa J Schafer.

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  • bioRxiv  ·  December 18, 2025  ·  Preprint

    Wavelet Based Whole Genome Doubling Aware Single Cell Copy Number Calling.

    Benjamin Kumar Wesley, Frank Wos, Soren GRermer, Jade EB Carter, Silas Maniatis, Khanh N Dinh, Timothy Chu, Nicolas Robine, Rebecca Fitzgerald, Lizhe Zhuang Simon Tavare, Karol Nowicki-Osuch.

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  • Eur Heart J  ·  December 22, 2025

    LIPA, a risk locus for coronary artery disease: decoding the variant-to-function relationship.

    Fang Li, Elise Flynn, Philip Ha, Mazal N Zebak, Haoxiang Cheng, Chenyi Xue, Jianting Shi, Xun Wu, Ziyi Wang, Yujiao Meng, Jian Cui, Yizhou Zhu, Annie Rozenblyum, Jeana Chun, Antonio Hernandez-Ono, Ali Javaheri, Babak Razani, Marit Westerterp, Robert C Bauer, Yousin Suh, Ke Hao, Tuuli Lappalainen, Hanrui Zhang.

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  • Nat Commun .  ·  December 20, 2025

    Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D

    Biswanath Chowdhury, Kaiyuan Zhu, Chaohui Li, Jessica Alsing, Jens Luebeck, Maria E Stefanova, Owen S Chapman, Katerina Kraft, Shu Zhang, Jun Yi Stanley Lim, Yipeng Xie, Yoon Jung Kim, Sihan Wu, Lukas Chavez, Guy Nir, Anton G Henssen, Paul S Mischel, Howard Y Chang, Vineet Bafna.

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  • Alzheimer's & Dementia  ·  December 21, 2025

    Bridging neurodevelopment and neurodegeneration in genetic frontotemporal dementia and Alzheimer’s disease.

    Youjin Jung, Jolina Lombardi, Rowan Heffelfinger, Sarah Inkelis, Christa Watson Pereira, Taru M Flagan, Matthew Hall, Liya Rabkina, Zachary Miller, Stephan Sanders, Virginia E Sturm, Jalayne J Arias, Bruce L Miller, Adam L Boxer, John M Ringman, Maria Luisa Mandelli, Maria Luisa Gorno Tempini, Suzee E Lee

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  • Alzheimer's & Dementia  ·  December 21, 2025

    Structural Variants Associated with Sporadic Alzheimer’s Disease Pathologies and Segregates in Caribbean Hispanics and Non-Hispanic White Families.

    Tamil Iniyan Gunasekaran, Dolly Reyes-Dumeyer, André Corvelo, Wayne E. Clarke, Uday S. Evani, Marta S. Byrska-Bishop, Anna O. Basile, Alexi Runnels, Rajeeva O. Musunuri, Giuseppe Narzisi, Hui Wang, Kelley M. Faber, Alison M. Goate, Brad F Boeve, Carlos Cruchaga, Margaret Pericak-Vance, Jonathan L Haines, Roger N Rosenberg, Debby W Tsuang, Diones Rivera Mejia, Martin Medrano, Rafael A. Lantigua, Robert Sweet, David A. A. Bennett, Robert S. Wilson, Tatiana M. Foroud, Wan-Ping Lee, Gerald D. Schellenberg, Clifton L. Dalgard, Richard Mayeux, Michael Zody, Badri N. Vardarajan

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  • Alzheimer's & Dementia  ·  December 21, 2025

    ProtBAG: eleven organ-specific proteome-based biological ageusing CSF proteomics.

    Sarah Ko, Hui Cao, Mehrshad Saadatinia, Gao Wang, Elisa Konofagou, Donald Edmondson, Wenjia Bai, Arthur W. Toga, Christiane Reitz, Ye Ella Tian, Andrew Zalesky, Christos Davatzikos, Junhao Wen

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  • medRxiv  ·  December 20, 2025  ·  Preprint

    Regulatory landscape of Alzheimer’s disease variants in human microglia.

    Chia-Yi Lee, Ashvin Ravi, Tzu-Chieh Huang, Briana Wyman, Ziyu Liu, Ariana Chriss, Jack Humphrey, David A. Knowles, Chris Cotsapas, Laura M. Huckins, Towfique Raj, Kristen J. Brennand

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  • medRxiv  ·  December 18, 2025  ·  Preprint

    Improved Identification of Large-effect Rare Genetic Variants using Haplotype Aggregated Allele-specific Expression Data.

    Kaushik Ram Ganapathy, Martin Broly, Sarah Silverstein, Marcela Mendoza, Eric Song, Bence Kotis, Paul Hoffman, PCGC Consortium, Ali Torkamani, David R Adams, Carsten Bonnemann, Tuuli Lappalainen, Pejman Mohammadi

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  • Nature  ·  December 17, 2025

    An integrated view of the structure and function of the human 4D nucleome.

    Job Dekker, Betul Akgol Oksuz, Yang Zhang, Ye Wang, Miriam K. Minsk, Shuzhen Kuang, Liyan Yang, Johan H. Gibcus, Nils Krietenstein, Oliver J. Rando, Jie Xu, Derek H. Janssens, Steven Henikoff, Alexander Kukalev, Willemin Andréa, Warren Winick-Ng, Rieke Kempfer, Ana Pombo, Miao Yu, Pradeep Kumar, Liguo Zhang, Andrew S. Belmont, Takayo Sasaki, Tom van Schaik, Laura Brueckner, Daan Peric-Hupkes, Bas van Steensel, Ping Wang, Haoxi Chai, Minji Kim, Yijun Ruan, Ran Zhang, Sofia A. Quinodoz, Prashant Bhat, Mitchell Guttman, Wenxin Zhao, Shu Chien, Yuan Liu, Sergey V. Venev, Dariusz Plewczynski, Ibai Irastorza Azcarate, Dominik Szabó, Christoph J. Thieme, Teresa Szczepińska, Mateusz Chiliński, Kaustav Sengupta, Mattia Conte, Andrea Esposito, Alex Abraham, Ruochi Zhang, Yuchuan Wang, Xingzhao Wen, Qiuyang Wu, Yang Yang, Jie Liu, Lorenzo Boninsegna, Asli Yildirim, Yuxiang Zhan, Andrea Maria Chiariello, Simona Bianco, Lindsay Lee, Ming Hu, Yun Li, R. Jordan Barnett, Ashley L. Cook, Daniel J. Emerson, Claire Marchal, Peiyao Zhao, Peter J. Park, Burak H. Alver, Andrew J. Schroeder, Rahi Navelkar, Clara Bakker, William Ronchetti, Shannon Ehmsen, Alexander D. Veit, Nils Gehlenborg, Ting Wang, Daofeng Li, Xiaotao Wang, Mario Nicodemi, Bing Ren, Sheng Zhong, Jennifer E. Phillips-Cremins, David M. Gilbert, Katherine S. Pollard, Frank Alber, Jian Ma, William S. Noble & Feng Yue

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  • Nature Communications  ·  December 16, 2025

    Multi-layered transcriptional control of glycogen metabolism coordinates thermogenic remodeling of white adipocytes in male mice.

    Haipeng Fu, Seoyeon Lee, Nathan R. Zemke, Weiwei Fan, Yunqing Wang, James Garza, David Tin, Bryce Villao, Bichen Zhang, Xianda Ma, Jinyang Zhang, Tangran Dong, Yuyao Ren, Michael Downes, Ronald M Evans, Bing Ren & Alan R. Saltiel

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  • Molecular Therapy  ·  December 11, 2025

    Targeted BDNF upregulation via upstream open reading frame disruption.

    Ning Feng, Thomas Goedert, Nenad Svrzikapa, Dongnan Yan, Hans J Friedrichsen, Britt Hanson, Alicia Ljungdahl, Ruxandra Dafinca, Kevin Talbot, Stephan J Sanders, Dhanu Gupta, Mathew J A Wood, Thomas C Roberts.

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  • bioRxiv  ·  December 10, 2025  ·  Preprint

    Reconstructing developmental and disease progression with sample-level embeddings.

    Longda Jiang, Zhixin Cyrillus Tan, Isabella N. Grabski, Yuhan Hao, Nathan Nakatsuka, Sourav Sarkar, Anagha Shenoy, Rahul Satija.

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  • bioRxiv  ·  December 12, 2025  ·  Preprint

    Engineered AAV Capsids with Enhanced Extracellular Vesicle Loading via Rational Design and Directed Evolution.

    oulia Vorobieva, Marina Luchner, Hans friedrichsen, Ruhani Makkar, Simon Chester, Emily Haughton, Mariana Conceicao, Harrison Steel, Stephan J Sanders, Matthew Wood, Dhanu Gupta.

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  • Molecular Oncology  ·  December 15, 2025

    Developing evidence-based, cost-effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities.

    Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou-Zeid, Vanderlei Bagnato, Christian Brandts, Chien-Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking

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  • Clinical and Translational Medicine  ·  December 15, 2025

    The ‘vulnerability code’: Is cell identity the architect of its own decay?

    Dongsheng Bai, Zhenkun Cao, Chenxu Zhu

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