Publications

27 Results (Filters Applied)

Sanjana Lab x

Nature Biotechnology 2021 Apr. 29.

Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens.

Noa Liscovitch-Brauer, Antonino Montalbano, Jiale Deng, Alejandro Méndez-Mancilla, Hans-Hermann Wessels, Nicholas G. Moss, Chia-Yu Kung, Akash Sookdeo, Xinyi Guo, Evan Geller, Suma Jaini, Peter Smibert & Neville E. Sanjana

Genome Biology. 2021 Mar. 4.

Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity.

Sorek M, Oweis W, Nissim-Rafinia M, Maman M, Simon S, Hession CC, Adiconis X, Simmons SK, Sanjana NE, Shi X, Lu C, Pan JQ, Xu X, Pouladi MA, Ellerby LM, Zhang F, Levin JZ, Meshorer E.

eLife. 2021 Feb. 11.

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types.

Zharko Daniloski, Tristan X. Jordan, Juliana K. Ilmain, Xinyi Guo, Gira Bhabha, Benjamin R. tenOever3, Neville E. Sanjana

Cell. 2020 Oct. 24.

Identification of required host factors for SARS-CoV-2 infection in human cells.

Zharko Daniloski, Tristan X. Jordan, Hans-Hermann Wessels, Daisy A. Hoagland, Silva Kasela, Mateusz Legut, Silas Maniatis, Eleni P. Mimitou, Lu Lu, Evan Geller, Oded Danziger, Brad R. Rosenberg, Hemali Phatnani, Peter Smibert, Tuuli Lappalainen, Benjamin R. tenOever, Neville E. Sanjana

Nature Biotechnology. 2020 Mar. 16.

Massively parallel Cas13 screens reveal principles for guide RNA design.

Hans-Hermann Wessels, Alejandro Méndez-Mancilla, Xinyi Guo, Mateusz Legut, Zharko Daniloski & Neville E. Sanjana.

Cell Reports. 2020 Mar. 3

High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation.

Legut M, Daniloski Z, Xue X, McKenzie D, Guo X, Wessels HH, Sanjana NE.

Stem Cell Research. 2019 Nov. 1.

Generation of a knock-in MAP2-tdTomato reporter human embryonic stem cell line with inducible expression of NEUROG2/1 (NYGCe001-A).

Lu C, Sanjana NE.

Nature Biomedical Engineering. 2019 Sep. 23.

Immunomagnetic cell sorting.

Legut M, Sanjana NE.

Cell Systems. 2019

Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes.

Eric Minwei Liu, Alexander Martinez-Fundichely, Bianca Jay Diaz, Boaz Aronson, Tawny Cuykendall, Matthew MacKay
Priyanka Dhingra, Elissa W.P. Wong, Ping Chi, Effie Apostolou, Neville E. Sanjana, Ekta Khurana

Nature Methods. 2019 Apr 22.

Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells.

Eleni P. Mimitou, Anthony Cheng, Antonino Montalbano, Stephanie Hao, Marlon Stoeckius, Mateusz Legut, Timothy Roush, Alberto Herrera, Efthymia Papalexi, Zhengqing Ouyang, Rahul Satija, Neville E. Sanjana, Sergei B. Koralov & Peter Smibert.

FASEB J. 2019 Jan. 30.

Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons.

Lu C, Shi X, Allen A, Baez-Nieto D, Nikish A, Sanjana NE, Pan JQ.

Cell Stem Cell. 2018 Aug, 2.

GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease.

Li L, Tian E, Chen X, Chao J, Klein J, Qu Q, Sun G, Sun G, Huang Y, Warden CD, Ye P, Feng L, Li X, Cui Q, Sultan A, Douvaras P, Fossati V, Sanjana NE, Riggs AD, Shi Y.

Science Translational Medicine. 2018 Aug. 8

A genome-wide net to catch and understand cancer

Sanjana, NE.

American Journal of Medical Genetics. 2018 May 7.

Two Angelman families with unusually advanced neurodevelopment carry a start codon variant in the most highly expressed UBE3A isoform.

Sadhwani A, Sanjana NE, Willen JM, Calculator SN, Black ED, Bean LJH,, Li H., Tan WH.

Nat Protocols. 2018 Apr. 12.

Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments.

Canver MC, Haeussler M, Bauer DE, Orkin SH, Sanjana NE, Shalem O, Yuan GC, Zhang F, Concordet JP, Pinello L.

Nature Biomedical Engineering. 2018 Apr. 9.

Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons.

Tekin H, Simmons S, Cummings B, Gao L, Adiconis X, Hession CC, Ghoshal A, Dionne D, Choudhury SR, Yesilyurt V, Sanjana NE, Shi X, Lu C, Heidenreich, Pan JQ, Levin JZ & Zhang F.

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1016). Chapter First Online: 2017 Nov. 13.

Target Discovery for Precision Medicine Using High-Throughput Genome Engineering.

Guo X, Chitale P, Sanjana NE.

Molecular Cell. 2017 Oct. 5.

High-Throughput Approaches to Pinpoint Function within the Noncoding Genome.

Montalbano A, Canver, MC and Sanjana NE.

PRE-PRINT PUBLICATIONS

medRxiv. 2021 Apr. 13.

Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus.

, Zharko Daniloski, , Benjamin R. tenOever, Neville E. Sanjana, Tuuli Lappalainen

bioRxiv. 2021 Apr. 8

Discovery of target genes and pathways of blood trait loci using pooled CRISPR screens and single cell RNA sequencing.

John A Morris, Zharko Daniloski, Júlia Domingo, Timothy Barry, Marcello Ziosi, Dafni A Glinos, Stephanie Hao, Eleni Mimitou, Peter Smibert, Kathryn Roeder, Eugene Katsevich, Tuuli Lappalainen, Neville E Sanjana

bioRxiv. 2021 Jan. 14.

An Effector Index to Predict Causal Genes at GWAS Loci

Vincenzo Forgetta, Lai Jiang, Nicholas A Vulpescu, Megan S Hogan, Siyuan Chen, John A Morris, Stepan Grinek, Christian Benner, Dong-Keun Jang, Quy Hoang, Noel Burtt, Jason A Flannick, Mark I Mccarthy, Eric Fauman, Celia MT Greenwood, Matthew T Maurano, J Brent Richards

bioRxiv. 2020 Nov. 23.

The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by pausing POL II at pro-differentiation genes.

Görkem Garipler, Congyi Lu, Alexis Morrissey, Lorena S. Lopez-Zepeda, Simon E. Vidal, Begüm Aydin, Matthias Stadtfeld, Uwe Ohler, Shaun Mahony, Neville E. Sanjana, Esteban O. Mazzoni

bioRxiv.. 2020 Nov. 21.

Scalable pooled CRISPR screens with single-cell chromatin accessibility profiling.

Noa Liscovitch-Brauer, Antonino Montalbano, Jiale Deng, Alejandro Mendez-Mancilla, Hans-Hermann Wessels, Nicholas G Moss, Chia-Yu Kung, Akash Sookdeo, Xinyi Guo, Evan Geller, Suma Jaini, Peter Smibert, Neville E Sanjana

bioRxiv. 2020 August 19.

CRISPR-Decryptr reveals cis-regulatory elements from noncoding perturbation screens.

Anders West Rasmussen, Tarmo Äijö, Mariano Ignacio Gabitto, Nick Carriero, Neville Sanjana, Jane Skok, Richard Bonneau

bioRxiv. 2020 May 9.

Automated design of CRISPR prime editors for thousands of human pathogenic variants.

John A Morris, Jahan A Rahman, Xinyi Guo, Neville E Sanjana

bioRxiv. 2019 Nov. 18.

Genome-wide profiling of druggable active tumor defense mechanisms to enhance cancer immunotherapy

, , Suman K Vodnala, Amy K Decker, Yogin Patel, Madhusudhanan Sukumar, , Zhiya Yu, Michelle Ji, Amanda N Henning, Devikala Gurusamy, Douglas C Palmer, Winifred Lo, , Parisa Malekzadeh, Drew C Deniger, Kris C Wood, Neville E. Sanjana, Nicholas P Restifo

Faculty labs

NYGC Labs