Publications

23 Results (Filters Applied)

Sanjana Lab x

Nature Biotechnology. 2020 Mar. 16.

Massively parallel Cas13 screens reveal principles for guide RNA design.

Hans-Hermann Wessels, Alejandro Méndez-Mancilla, Xinyi Guo, Mateusz Legut, Zharko Daniloski & Neville E. Sanjana.

Cell Reports. 2020 Mar. 3

High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation.

Legut M, Daniloski Z, Xue X, McKenzie D, Guo X, Wessels HH, Sanjana NE.

Stem Cell Research. 2019 Nov. 1.

Generation of a knock-in MAP2-tdTomato reporter human embryonic stem cell line with inducible expression of NEUROG2/1 (NYGCe001-A).

Lu C, Sanjana NE.

Nature Biomedical Engineering. 2019 Sep. 23.

Immunomagnetic cell sorting.

Legut M, Sanjana NE.

Cell Systems. 2019

Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes.

Eric Minwei Liu, Alexander Martinez-Fundichely, Bianca Jay Diaz, Boaz Aronson, Tawny Cuykendall, Matthew MacKay
Priyanka Dhingra, Elissa W.P. Wong, Ping Chi, Effie Apostolou, Neville E. Sanjana, Ekta Khurana

Nature Methods. 2019 Apr 22.

Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells.

Eleni P. Mimitou, Anthony Cheng, Antonino Montalbano, Stephanie Hao, Marlon Stoeckius, Mateusz Legut, Timothy Roush, Alberto Herrera, Efthymia Papalexi, Zhengqing Ouyang, Rahul Satija, Neville E. Sanjana, Sergei B. Koralov & Peter Smibert.

FASEB J. 2019 Jan. 30.

Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons.

Lu C, Shi X, Allen A, Baez-Nieto D, Nikish A, Sanjana NE, Pan JQ.

Cell Stem Cell. 2018 Aug, 2.

GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease.

Li L, Tian E, Chen X, Chao J, Klein J, Qu Q, Sun G, Sun G, Huang Y, Warden CD, Ye P, Feng L, Li X, Cui Q, Sultan A, Douvaras P, Fossati V, Sanjana NE, Riggs AD, Shi Y.

Science Translational Medicine. 2018 Aug. 8

A genome-wide net to catch and understand cancer

Sanjana, NE.

American Journal of Medical Genetics. 2018 May 7.

Two Angelman families with unusually advanced neurodevelopment carry a start codon variant in the most highly expressed UBE3A isoform.

Sadhwani A, Sanjana NE, Willen JM, Calculator SN, Black ED, Bean LJH,, Li H., Tan WH.

Nat Protocols. 2018 Apr. 12.

Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments.

Canver MC, Haeussler M, Bauer DE, Orkin SH, Sanjana NE, Shalem O, Yuan GC, Zhang F, Concordet JP, Pinello L.

Nature Biomedical Engineering. 2018 Apr. 9.

Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons.

Tekin H, Simmons S, Cummings B, Gao L, Adiconis X, Hession CC, Ghoshal A, Dionne D, Choudhury SR, Yesilyurt V, Sanjana NE, Shi X, Lu C, Heidenreich, Pan JQ, Levin JZ & Zhang F.

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1016). Chapter First Online: 2017 Nov. 13.

Target Discovery for Precision Medicine Using High-Throughput Genome Engineering.

Guo X, Chitale P, Sanjana NE.

Molecular Cell. 2017 Oct. 5.

High-Throughput Approaches to Pinpoint Function within the Noncoding Genome.

Montalbano A, Canver, MC and Sanjana NE.

Nature Reviews Immunology. 2017 August 7.

Single-cell RNA sequencing to explore immune cell heterogeneity.

Papalexi E, Satija R.

Nature. 2017 August 7.

Identification of essential genes for cancer immunotherapy.

Patel SJ, Sanjana NE, Kishton RJ, Eidizadeh A, Vodnala SK, Cam M, Gartner JJ, Jia, L, Steinberg SM, Yamamoto TN, Merchant, AS, Mehta, GU, Chichura A, Shalem O, Tran E, Eil, R, Sukumar M, Perez Guijarro E, Day C-P, Robbins P, Feldman S, Merlino G, Zhang F, Restifo, NP.

Nature Methods. 2017 August 31.

GUIDES: sgRNA design for loss-of-function screens.

Meier, JA, Zhang F, Sanjana, NE.

Nature Protocols. 2017 Mar 23.

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.

Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE, Zhang F.

PRE-PRINT PUBLICATIONS

bioRxiv. 2020 August 19.

CRISPR-Decryptr reveals cis-regulatory elements from noncoding perturbation screens.

Anders West Rasmussen, Tarmo Äijö, Mariano Ignacio Gabitto, Nick Carriero, Neville Sanjana, Jane Skok, Richard Bonneau

bioRxiv. 2020 July 7.

The D614G mutation in SARS-CoV-2 Spike increases transduction of multiple human cell types.

Zharko Daniloski, Tristan X. Jordan, Juliana Ilmain, Xinyi Guo, , Benjamin tenOever, Neville E Sanjana

bioRxiv. 2020 May 9.

Automated design of CRISPR prime editors for thousands of human pathogenic variants.

John A Morris, Jahan A Rahman, Xinyi Guo, Neville E Sanjana

bioRxiv. 2019 Nov. 18.

Genome-wide profiling of druggable active tumor defense mechanisms to enhance cancer immunotherapy

, , Suman K Vodnala, Amy K Decker, Yogin Patel, Madhusudhanan Sukumar, , Zhiya Yu, Michelle Ji, Amanda N Henning, Devikala Gurusamy, Douglas C Palmer, Winifred Lo, , Parisa Malekzadeh, Drew C Deniger, Kris C Wood, Neville E. Sanjana, Nicholas P Restifo

Faculty labs

NYGC Labs