Publications

53 Results (Filters Applied)
  • Lappalainen Lab x
Annals of the American Thoracic Society. 2024 Feb 8.

Peripheral Blood Mononuclear Cell Gene Expression Associated with Pulmonary Microvascular Perfusion: The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease Study.

Kristina L. Buschur, Tess D. Pottinger, Jens Vogel-Claussen, Charles A Powell, Francois Aguet, Norrina B Allen, Kristin Ardlie, David A. Bluemke, Peter Durda, Emilia A. Hermann, Eric A. Hoffman, João A.C. Lima, Yongmei Liu, Daniel Malinsky, Ani Manichaikul, Amin Motahari, Wendy S. Post, Martin R. Prince, Stephen S. Rich, Jerome I Rotter, Benjamin M. Smith, Russell P Tracy, Karol Watson, Hinrich B. Winther, Tuuli Lappalainen, R Graham Barr

American Journal of Human Genetics. 2023 Jan 4.

Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects.

Silva Kasela, François Aguet, Sarah Kim-Hellmuth, Brielin C. Brown, Daniel C. Nachun, Russell P. Tracy, Peter Durda, Yongmei Liu, Kent D. Taylor, W. Craig Johnson, David Van Den Berg, Stacey Gabriel, Namrata Gupta, Joshua D. Smith, Thomas W. Blackwell, Jerome I. Rotter, Kristin G. Ardlie, Ani Manichaikul, Stephen S. Rich, R. Graham Barr, Tuuli Lappalainen

Cell Genomics. 2023 Sept. 6.

The functional impact of rare variation across the regulatory cascade.

Taibo Li, Nicole Ferraro, Benjamin J. Strober, Francois Aguet, Silva Kasela, Marios Arvanitis, Bohan Ni, Laurens Wiel, Elliot Hershberg, Kristin Ardlie, Dan E. Arking, Rebecca L. Beer, Jennifer Brody, Thomas W. Blackwell, Clary Clish, Stacey Gabriel, Robert Gerszten, Xiuqing Guo, Namrata Gupta, W. Craig Johnson, Tuuli Lappalainen, Henry J. Lin, Yongmei Liu, Deborah A. Nickerson, George Papanicolaou, Jonathan K. Pritchard, Pankaj Qasba, Ali Shojaie, Josh Smith, Nona Sotoodehnia, Kent D. Taylor, Russell P. Tracy, David Van Den Berg, Matthew T. Wheeler, Stephen S. Rich, Jerome I. Rotter, Alexis Battle, Stephen B. Montgomery

PLoS Genetics. 2023 June 23.

Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes.

Eric Van Buren, Giorgia Radicioni, Sarah Lester, Wanda K. O’Neal, Hong Dang, Silva Kasela, Suresh Garudadri, Jeffrey L. Curtis, MeiLan K. Han, Jerry A. Krishnan, Emily S. Wan, Edwin K. Silverman, Annette Hastie, Victor E. Ortega, Tuuli Lappalainen, Martijn C. Nawijn, Maarten van den Berge, Stephanie A. Christenson, Yun Li, Michael H. Cho, Mehmet Kesimer, Samir N. P. Kelada

Genetics. 2023 June 22.

Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants.

Jonah Einson, Dafni Glinos, Eric Boerwinkle, Peter Castaldi, Dawood Darbar, Mariza de Andrade, Patrick Ellinor, Myriam Fornage, Stacey Gabriel, Soren Germer, Richard Gibbs, Craig Hersh, Jill Johnsen, Robert Kaplan, Barbara Konkle, Charles Kooperberg, Rami Nassir, Ruth J.F. Loos, Deborah A Meyers, Braxton D. Mitchell, Bruce Psaty, Ramachandran S. Vasan, Stephen S. Rich, Michael Rienstra, Jerome I. Rotter, Aabida Saferali, M. Benjamin Shoemaker, Edwin Silverman, Albert Vernon Smith, Pejman Mohammadi, Stephane E Castel, Ivan Iossifov, Tuuli Lappalainen

Thorax. 2023 June 2.

Pulmonary emphysema subtypes defined by unsupervised machine learning on CT scans.

Elsa D Angelini, Jie Yang, Pallavi P Balte, Eric A Hoffman, Ani W Manichaikul, Yifei Sun, Wei Shen, John H M Austin, Norrina B Allen, Eugene R Bleecker, Russell Bowler, Michael H Cho, Christopher S Cooper, David Couper , Mark T Dransfield, Christine Kim Garcia, MeiLan K Han, Nadia N Hansel, Emlyn Hughes, David R Jacobs, Silva Kasela, Joel Daniel Kaufman, John Shinn Kim, Tuuli Lappalainen, Joao Lima, Daniel Malinsky, Fernando J Martinez, Elizabeth C Oelsner, Victor E Ortega, Robert Paine, Wendy Post, Tess D Pottinger, Martin R Prince, Stephen S Rich, Edwin K Silverman, Benjamin M Smith, Andrew J Swift, Karol E Watson, Prescott G Woodruff, Andrew F Laine, R Graham Barr

PLOS Genetics. 2023 May 22.

Canonical correlation analysis for multi-omics: Application to cross-cohort analysis.

Min-Zhi Jiang, François Aguet, Kristin Ardlie, Jiawen Chen, Elaine Cornell, Dan Cruz, Peter Durda, Stacey B. Gabriel, Robert E. Gerszten, Xiuqing Guo, Craig W. Johnson, Silva Kasela, Leslie A. Lange, Tuuli Lappalainen, Yongmei Liu, Alex P. Reiner, Josh Smith, Tamar Sofer, Kent D. Taylor, Russell P. Tracy, David J. VanDenBerg, James G. Wilson, Stephen S. Rich, Jerome I. Rotter, Michael I. Love, Laura M. Raffield, Yun Li, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Analysis Working Group

BMC. 2023 Jan. 25.

Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis.

Kristina L. Buschur, Craig Riley, Aabida Saferali, Peter Castaldi, Grace Zhang, Francois Aguet, Kristin G. Ardlie, Peter Durda, W. Craig Johnson, Silva Kasela, Yongmei Liu, Ani Manichaikul, Stephen S. Rich, Jerome I. Rotter, Josh Smith, Kent D. Taylor, Russell P. Tracy, Tuuli Lappalainen, R. Graham Barr, Frank Sciurba, Craig P. Hersh & Panayiotis V. Benos

Nature. 2022 Aug. 3.

Transcriptome variation in human tissues revealed by long-read sequencing.

Dafni A. Glinos, Garrett Garborcauskas, Paul Hoffman, Nava Ehsan, Lihua Jiang, Alper Gokden, Xiaoguang Dai, François Aguet, Kathleen L. Brown, Kiran Garimella, Tera Bowers, Maura Costello, Kristin Ardlie, Ruiqi Jian, Nathan R. Tucker, Patrick T. Ellinor, Eoghan D. Harrington, Hua Tang, Michael Snyder, Sissel Juul, Pejman Mohammadi, Daniel G. MacArthur, Tuuli Lappalainen & Beryl B. Cummings

Nature Reviews Methods Primers. 2021 Aug. 26.

Genome-wide association studies.

Emil Uffelmann, Qin Qin Huang, Nchangwi Syntia Munung, Jantina de Vries, Yukinori Okada, Alicia R. Martin, Hilary C. Martin, Tuuli Lappalainen & Danielle Posthuma

Hum Mol Genet. 2021 Aug. 20.

Epigenome-wide association study of mitochondrial genome copy number.

Wang P, Castellani CA, Yao J, Huan T, Bielak LF, Zhao W, Haessler J, Roby J, Sun X, Guo X, Longchamps RJ, Manson JE, Grove ML, Bressler J, Taylor KD, Lappalainen T, Kasela S, Van Den Berg DJ, Hou L, Reiner A, Liu Y, Boerwinkle E, Smith JA, Peyser PA, Fornage M, Rich SS, Rotter JI, Kooperberg C, Arking DE, Levy D, Liu C; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium..

This work was partially supported by a gift from the Simons Foundation.