• bioRxiv  ·  August 10, 2026  ·  Preprint

    Time-resolved lineage recording reveals a pre-existing, heritable cell state underlying metastatic potential.

    Jihye Park, Yoojin Chang, Joshua S Schiffman, Divya Koyyalagunta, Hrishikesh Somayaji, Caden N McQuillen, Joseph Chan, Quaid Morris, Dan Landau, Hyongbum Henry Kim, Junhong Choi.

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  • Nature  ·  August 5, 2026

    A compendium of next-generation patient-derived models for diverse cancers.

    Dina ElHarouni, Mushriq Al-Jazrawe, Seongmin Choi, Merve Dede, Toshinori Hinoue, Sean A Misek, Heeju Noh, Luca Zanella, Yuen-Yi Tseng, Hayley E Francies, Dennis Plenker, Cindy W Kyi, Julyann Perez-Mayoral, Megan J Stine, Eva Tonsing-Carter, Rachana Agarwal, Jean Claude Zenklusen, James M Clinton, Jennifer M Shelton, Timothy R Chu, William F Hooper, Xavi Loinaz, Paula Keskula, Jordan Tagle, Peyton C Kuhlers, Bahar Tercan, Sylvia F Boj, Alessandro Vasciaveo, Lorenzo Tomassoni, James M Crawford, Shawna Walsh, Claire Sinai, Sonam Bhatia, Priya Sridevi, Hardik Patel, Maria Antonietta Cerone; HCMI Network; Kyle Ellrott, Calvin J Kuo, Olivier Elemento, Semir Beyaz, Vincenzo Corbo, David L Spector, Rameen Beroukhim, Martin L Ferguson, Andrew D Cherniack, Peter W Laird, Nicolas Robine, Andrew McPherson, Katherine A Hoadley, Mathew J Garnett, David A Tuveson, Andrea Califano, Paul T Spellman, Keith L Ligon, Daniela S Gerhard, Louis M Staudt, Jesse S Boehm.

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  • bioRxiv  ·  July 31, 2026  ·  Preprint

    Benchmarking Twist Genotyping-by-Sequencing Against Whole-Genome Sequencing in Nuclear Families.

    Jacob Klugerman, Ivan Iossifov, Kenny Ye.

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  • medRxiv  ·  August 3, 2026  ·  Preprint

    Guidance for clinical variant classification in genes for spliceosomal small nuclear RNAs.

    Elston N DSouza, Alexander JM Blakes, Robin Paluch, Siddharth Banka, Maya Chopra, Alison J Coffey, Christel Depienne, Wojciech P Galej, Sylvie Mazoyer, Caroline Nava, Anne O’Donnell Luria, Jillian O’Toole, Pia Riestra Crespo, Carlo Rivolta, Stephan J Sanders, Nicola Whiffin.

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  • Cell  ·  August 4, 2026

    Distinct cellular phenotypes of language and executive decline in amyotrophic lateral sclerosis.

    Joana Petrescu, Cláudio Gouveia Roque, Christopher A. Jackson, Aidan C. Daly, Zoé Butti, Kristy Kang, Obadele Casel, Matthew Leung, Luke Reilly, Jacqueline Eschbach, Brhan Gebremedhin, Karina McDade, Jenna M. Gregory, Richard Bonneau, Colin Smith, Hemali Phatnani

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  • medRxiv  ·  July 31, 2026  ·  Preprint

    Systematic Integration of genomics with transcriptomics for the Study of Coronary Artery Disease and Subclinical Atherosclerosis.

    Chaojie Yang, Francois Aguet, Gaelle Auguste, Kristin G Ardlie, Robert E Gerszten, Wendy S. Post, Heather E Wheeler, Kent D. Taylor, Silva Kasela, Tuuli Lappalainen, Hae Kyung lm, Peter Durda, W. Craig Johnson, Xiuqing Guo, Yongmei Liu, Joseph F. Polak, David M. Herrington, Clary B. Clish, David Van Den Berg, Russell P. Tracy, Elaine Cornell, Thomas W. Blackwell, George J Papanicolaou, Jose D. Vargas, Stefan Bekiranov, Coleen A McNamara,lint L Miller, Jerome I. I. Rotter, Stephen S. S. Rich, Ani W. Manichaikul

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  • Cancer Discovery  ·  August 3, 2026

    SPEN Loss Drives Extrafollicular Diffuse Large B-cell Lymphoma with Female-Specific Lethality and Therapeutic Vulnerabilities.

    Benedikt Pelzer, Cem Meydan, Isaac M Spiegel, Ioannis Karagiannidis, Min Xia, Matt Teater, Emma M Welter, Zowie E Searcy, Laura K Hilton, Darko Barisic, Amos Fong, Pengyan Fa, Shenon Sethi, Irem S Isgor, Jessie J Fielding, Alireza Karbalayghareh, Colin S Burdette, Sravya Tumuluru, Sonia M Debek, Sunjae Lee, Ramon Massoni-Badosa, Ceyda Durmaz, Eralda Salataj, Prasath Pararajalingam, Zhengming Chen, Richard J Pelzl, Sanket Shah, Martin A Rivas, Kenneth B Hoehn, Coraline Mlynarczyk, Hannah M Isles, Xiang Wang, Ahmet Dogan, Kojo S J Elenitoba-Johnson, David W Scott, Kostiantyn Dreval, Ryan D Morin, Christina S Leslie, Rishi Puri, Jacob B Geri, Christopher R Chin, Amy Chadburn, Christopher E Mason, Hans Christian Reinhardt, Montserrat C Anguera, Wendy Béguelin, Leandro Venturutti, Ari M Melnick

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  • International Journal of Population Data Science  ·  July 6, 2026

    Genetically informed phenotyping enables population research into rare developmental disorders in childhood.

    Ayana Cant, Patrick Campbell, Ruth Gilbert, Stephan Sanders, Ruth Blackburn.

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  • bioRxi  ·  July 29, 2026  ·  Preprint

    Minimally invasive monitoring of clonal evolution through integrated single cell and ctDNA analysis.

    Farhia Kabeer, Matteo Lepur, Branden Lynch, Emilia Hurtado, Elena Zaikova, Janine Senz, Vinci Au, Caroline Baril, Ding Ma, Sheila Nicholson, Gavin Ha, Jessica McAlpine, Samuel Aparicio, David Huntsman, Alexandre Bouchard-Cote, Yvette Drew, Andrew J. L. Roth.

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  • Nature Aging  ·  July 29, 2026

    Senotypes define the diverse landscape of senescent cells.

    Marissa J. Schafer, Nathan Basisty, Ann V. Hertzel, Alexandra N. Rindone, Jennifer H. Elisseeff, Vidyani Suryadevara, Constantin Aliferis, Paul D. Robbins, Laura J. Niedernhofer, Karl N. Miller, Peter D. Adams, Vilas Menon, Hemali Phatnani, Joao F. Passos, Birgit Schilling, Simon Melov, Nicola Neretti & Darren J. Baker

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  • bioRxiv  ·  July 28, 2026  ·  Preprint

    A multi-omics characterization reveals distinct molecular signatures in the human motor cortex and lumbar spinal cord in ALS.

    Natalie Barretto, Benjamin T Fullerton, Aidan C Daly, Obadele Casel, Olena Kuksenko, Kristy Kang, Joana Petrescu, Matthew Leung, Shruti Khiste, Brhan Gebremedhin, Colin Smith, Christopher Jackson, Hemali Phatnani

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  • Science Advances  ·  July 24, 2026

    Single-cell analysis of the epigenome and 3D chromatin architecture in the human retina.

    Ying Yuan, Pooja Biswas, Nathan R Zemke, Kelsey Dang, Yue Wu, Matteo D’Antonio, Yang Xie, Qian Yang, Keyi Dong, Pik Ki Lau, Daofeng Li, Chanrung Seng, Weronika Bartosik, Justin Buchanan, Lin Lin, Ryan Lancione, Kangli Wang, Seoyeon Lee, Zane Gibbs, Bing Yang, Joseph R Ecker, Kelly Frazer, Ting Wang, Sebastian Preissl, Allen Wang, Radha Ayyagari, Bing Ren

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  • Science  ·  July 23, 2026

    Human body single-cell atlas of three-dimensional genome organization and DNA methylation.

    Jingtian Zhou Yue Wu, Hanqing Liu, Wei Tian, Rosa G Castanon, Anna Bartlett, Zuolong Zhang, Guocong Yao, Dengxiaoyu Shi, Ben Clock, Samantha Marcotte, Joseph R Nery, Michelle Liem, Naomi Claffey, Lara Boggeman, Cesar Barragan, Rafael Arrojo E Drigo, Annika K Weimer, Minyi Shi, Johnathan Cooper-Knock, Sai Zhang, Michael P Snyder, Sebastian Preissl, Bing Ren, Carolyn O’Connor, Shengbo Chen, Chongyuan Luo, Jesse R Dixon, Joseph R Ecker

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  • Science  ·  July 23, 2026

    Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease-linked transcription factor.

    Zoe L Grant, Shuzhen Kuang, Shu Zhang, Abraham J Horrillo, Zhe Chen, Kavitha S Rao, Cemre Celen, Vasumathi Kameswaran, Carine Joubran, Pik Ki Lau, Keyi Dong, Bing Yang, Weronika M Bartosik, Nathan R Zemke, Bing Ren, Deepak Srivastava, Irfan S Kathiriya, Katherine S Pollard, Benoit G Bruneau

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  • Science  ·  July 23, 2026

    Epigenetic and 3D genome reprogramming during the aging of the human hippocampus.

    Nathan R Zemke, Seoyeon Lee, Sainath Mamde, Bing Yang, Nicole Berchtold, B Maximiliano Garduño, Hannah S Indralingam, Weronika M Bartosik, Pik Ki Lau, Keyi Dong, Emily Hsu, Amanda Yang, Yasmine Tani, Chumo Chen, Qiurui Zeng, Varun Ajith, Liqi Tong, Chanrung Seng, Daofeng Li, Ting Wang, Jingtian Zhou, Joseph R Ecker, Christopher K Glass, Carl W Cotman, Xiangmin Xu, Bing Ren

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  • Science  ·  July 23, 2026

    Single-cell multiomics and chromatin structure reveal gene-regulatory dynamics in heart failure.

    Yang Xie, Luca Tucciarone, Elie N Farah, Lei Chang, Qian Yang, Thirupura S Shankar, Weston Elison, Shaina Tran, Jovina Djulamsah, Audrey Lie, Timothy Loe, Alyssa R Holman, Sierra Corban, Justin Buchanan, Sainath Mamde, Haowen Zhou, Ruth M Elgamal, Eleni Tseliou, Vincent Huang, Zhaoning Wang, Jeffrey Huey-Chuan Chiu, Rebecca Melton, Emily Griffin, Qingquan Zhang, Jacinta Lucero, Sutip Navankasattusas, Daofeng Li, Chanrung Seng, Eugin Destici, Craig H Selzman, Agnieszka D’Antonio-Chronowska, Ting Wang, Allen Wang, Stavros G Drakos, Kyle J Gaulton, Bing Ren, Neil C Chi

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  • bioRxiv  ·  July 21, 2026  ·  Preprint

    Organism-scale annotation with Pan-human Azimuth.

    Sourav Sarkar, Zhuoyan Li, Gesmira Molla, Anagha Shenoy, Brian Zhang, David Collins, Nicole Vasilevsky, Joseph P. Gaut, Aleix Puig-Barbe, Andreas Bueckle, David Osumi-Sutherland, Katy Börner, Sanjay Jain, Rahul Satija

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  • bioRxiv  ·  July 21, 2026  ·  Preprint

    Bayesian Factor Analysis for Binary and Ordinal Phenotypes with Missingness.

    N. Shashaank, David A. Knowles.

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  • bioRxiv  ·  July 20, 2026  ·  Preprint

    Single-cell analysis of chromatin accessibility and gene expression in Drosophila melanogaster embryos following hypoxia treatment.

    Dan Zhou, Chenxu Zhu, Jin Xue, Caitlin Marsh, Tsering Stobdan, Bing Ren, Gabriel G. Haddad

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  • Genetics in Medicine Open  ·  July 17, 2026

    Genome and transcriptome sequencing reveal pathogenic activation of a pseudoexon in PKD1 via a de novo–common variant complex allele.

    Sangwoo T. Han, Atteeq U. Rehman, Sowmya Thirumalai Srinivasa, Alicia Lam, Michael Ficurilli, Vanessa Felice, Priya Krithivasan, Shruti Phadke, Avinash Abhyankar, Katherine Bergstrom, Jennifer A. Bassetti, Vaidehi Jobanputra

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