Dr. Tom Maniatis serves as the Evnin Family Scientific Director and Chief Executive Officer of the New York Genome Center (NYGC). One of the founders of the NYGC, Dr. Maniatis is the Isidore S. Edelman Professor of Biochemistry in the Department of Biochemistry and Molecular Biophysics at Columbia University, and the founding director of the University’s Precision Medicine Initiative.
Dr. Maniatis leads the research activities of the NYGC, including technology development and informatics, and directs the faculty and scientists in their individual and collaborative projects. He is recognized as one of the pioneers of modern molecular biology, having led the development of recombinant DNA methods and their application to the study of the mechanisms of gene regulation. He coauthored the definitive laboratory manual on genetic engineering, the Molecular Cloning Manual, along with Joe Sambrook and Ed Fritsch in 1982. This three-volume manual published by the Cold Spring Harbor Laboratory set a standard for international dissemination of recombinant DNA methods. Dr. Maniatis’ research has led to major advances in understanding the mechanisms of gene expression at the level of RNA transcription and splicing. His current research is focused on the role of single cell diversity in neural connectivity, and on the molecular mechanisms that underlie the neurodegenerative disease ALS (Lou Gehrig’s Disease).
Dr. Maniatis’ research contributions have been acknowledged by membership in the U.S. National Academy of Sciences and the Institute of Medicine, and by numerous awards, including, the Eli Lilly Research Award in Microbiology and Immunology, the Novartis Drew Award in Biomedical Research, the Richard Lounsbery Award for Biology and Medicine, and the Lasker Koshland Special Achievement Award in Medical Science. After receiving his BA and MS from the University of Colorado at Boulder and his PhD in molecular biology from Vanderbilt University, Dr. Maniatis carried out postdoctoral studies at Harvard and the Medical Research Council Laboratory of Molecular Biology in Cambridge, England. He has held faculty appointments at Harvard University, the Cold Spring Harbor Laboratory, and the California Institute of Technology.