Very Rare Cancer Consortium Disease Spotlight & Research Roundtable

March 18, 2021, 4:00pm – 6:00pm | New York Genome Center

Please join us for the Very Rare Cancer Consortium Tumor Board Meeting. This new initiative aims to bring cancer researchers across New York to the table to discuss compelling rare cancer cases presented by physicians and scientists from the New York Genome Center’s partner institutions. Click here to learn more about the Very Rare Cancer Consortium.

WHEN:
Thursday, March 18, 2021
4pm – 6pm

DESMOPLASTIC SMALL ROUND CELL TUMOR (DSRCT)

Disease Spotlight & Research Roundtable

This will be a VIRTUAL meeting via Zoom.
Please note registration is required.

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive cancer occurring predominantly in adolescents and young adults. Although DSRCT’s characteristic translocation between the EWSR1 and WT1 genes has been well described, the disease overall remains poorly understood and overall survival for patients with DSRCT remains unacceptably low. Given the rarity of the disease, no randomized trials have been performed and pre-clinical tools in which to study the disease remain limited, making collaborative efforts essential. We will hear from experts about the current understanding of DSRCT, review the many areas in which this understanding could be deepened, and discuss potential collaborations through the VRCC.

SPEAKERS AND AGENDA

Introduction to the Disease

Emily Slotkin, MD 
Pediatric Sarcoma Service, MSK KIDS
Memorial Sloan Kettering Cancer Center

 

Genomic and Molecular Landscape

Marc Ladanyi, MD
Attending Pathologist
and Chief, Molecular Diagnostics Service
Member, Human Oncology
& Pathogenesis Program
Memorial Sloan Kettering Cancer Center

Affiliate Member
New York Genome Center

 

Causes and Function of Chromosomal
Translocations in DSRCT

Alex Kentsis, MD, PhD
Director, Tow Center
for Developmental Oncology,
Sloan Kettering Institute
and Department of Pediatrics, MSK Kids
Memorial Sloan Kettering Cancer Center

Departments of Pediatrics, Pharmacology,
and Physiology & Biophysics,
Weill Medical College of Cornell University

 

Transcriptomics and Unique Bioinformation
Approaches in DSRCT

Andrea Califano, PhD
Clyde and Helen Wu Professor
of Chemical and Systems Biology
Founding Chair, Department
of Systems Biology
Director, JP Sulzberger Columbia
Genome Center
Associate Director for Bioinformatics,
Herbert Irving Comprehensive
Cancer Center
Columbia University Irving Medical Center

Affiliate Member
New York Genome Center

 

Prabhjot S. Mundi, MD
Department of Medicine
Division of Hematology/Oncology
Columbia University Irving Medical Center

 

Review of Investigational Therapeutic Approaches

Emily Slotkin, MD 
Pediatric Sarcoma Service, MSK KIDS
Memorial Sloan Kettering Cancer Center

 

Marc Ladanyi, MD
Attending Pathologist
and Chief, Molecular Diagnostics Service
Member, Human Oncology
& Pathogenesis Program
Memorial Sloan Kettering Cancer Center

Affiliate Member
New York Genome Center

 

Madelyn Espinosa-Cotton, PhD
Research Fellow
The Nai-Kong Cheung Lab
Memorial Sloan Kettering Cancer Center 

 

 

Lauren Banks, MD, PhD
Hematology/Oncology Fellow
Memorial Sloan Kettering Cancer Center

 

 

Joseph A. Ludwig, MD
Associate Professor
Department.of Sarcoma Medical Oncology,
Division of Cancer Medicine
University of Texas MD Anderson
Cancer Center


Discussion


Any questions on this event, contact events@nygenome.org.