MSK, NYGC Collaborative Study Pinpoints New Cause of Resistance to EGFR-Targeting Drugs

Fish lungcells
The image at right shows cells taken from a person with lung cancer and labeled with fluorescent probes (a technique called FISH). The red probe is specific for the YES1 gene. The green probe recognizes a part of chromosome 18 where YES1 is usually found. Cells with extra copies of the YES1 gene have significantly more red spots than green spots. Image courtesy Lu Wang.

A collaborative study between scientists at Memorial Sloan Kettering Cancer Center and the New York Genome Center has identified one way that lung cancer cells outsmart a common targeted drug therapy. The results, reported June 6, 2018 in the Proceedings of the National Academy of Sciences, pave the way for improved treatments.

Read the June 7 MSK blog story.