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April
2020
23
Steven Henikoff, PhD

4:00 PM — 6:00 PM

Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center

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About

Steven Henikoff, PhD

Investigator, Howard Hughes Medical Institute
Member, Fred Hutchinson Cancer Research Center

 

“Genome-Wide Mapping of Protein-DNA Interaction Dynamics”

 

REGISTER

 

4-5PM: Lecture & Audience Q&A
5-6PM: Networking & Cocktail Reception

 

We recently introduced new tools for high-resolution genome-wide chromatin profiling and have applied them to study chromatin organization and dynamics in a variety of model systems, including yeast, flies and mammals. Among the questions addressed are: How do transcription factors find their binding sites in DNA packaged into nucleosomes? How are nucleosomes depleted from gene regulatory regions? What is the relationship between nucleosome deposition pathways and chromatin deregulation in disease? Our findings illustrate ways in which chromatin dynamics can play a central role in regulating gene expression and silencing.

 

Steven Henikoff received a BS in Chemistry from the University of Chicago, a PhD in Biochemistry and Molecular Biology from Harvard University and performed postdoctoral work in Zoology at the University of Washington. He is a member of the Basic Sciences Division at the Fred Hutchinson Cancer Research Center and an investigator of the Howard Hughes Medical Institute. He is also an affiliate professor of Genome Sciences at the University of Washington, a member of the National Academy of Sciences, a fellow of the American Association for the Advancement of Science, and co-Editor-in-Chief of the journal Epigenetics & Chromatin. His laboratory performs research on chromatin dynamics, transcriptional regulation and centromere maintenance, and develops experimental and computational tools for studying these processes.

To learn more about Dr. Henikoff, visit his lab page.

 

Q&A Moderator:

Rahul Satija, PhD
Core Faculty Member
New York Genome Center

Assistant Professor, Center for Genomics and Systems Biology
New York University

  • EVENING TALKS
    The New York Genome Center’s Evening Talks events feature distinguished experts from around the world sharing genomic insights and research. They are intended to showcase and explain high science to the non-scientific community. Speakers present the latest research findings and explain its implication for helping improve clinical care for a wide array of serious diseases. The lecture is followed by a lively question-and-answer session and a post-event reception of hors d’oeuvres and cocktails. These popular free public events are held in the Center’s state-of-the-art ground-floor auditorium starting at 6:00 pm. The Evening Talks Series is sponsored by The New York Community Trust – Pyewacket Fund.

  • Workshops
  • Computational Cancer Genomics Working Group Evening Lectures
    Computational Cancer Genomics Working Group is led by Simon Tavaré, PhD, NYGC and Columbia University, and Sohrab Shah, PhD, Memorial Sloan Kettering Cancer Center. This group will build collaborations that apply novel statistical approaches and population-level analyses to major cohorts in cancer genomics.

  • Neurodegenerative Disease Working Group Evening Lectures
    The NYGC is leveraging the success of the Center for Genomics of Neurodegenerative Disease (CGND) to extend our work across a range of neurodegenerative diseases that have pathways in common with ALS, including Alzheimer’s, Parkinson’s and Huntington’s diseases. The NYGC has created a new Neurodegenerative Disease Working Group, led by Alison Goate, DPhil, Icahn School of Medicine at Mount Sinai, Hemali Phatnani, PhD, NYGC, and Phil De Jager, PhD, MD, MMSc, Columbia University Irving Medical Center, with the objective of bringing together researchers from NYGC’s institutional founding members, NYGC faculty, senior faculty, NYGC technology development and computational scientists, and affiliate members to discuss the underlying disease mechanisms in neurodegenerative disease.

  • Neuropsychiatric Disease Working Group Evening Lectures
    The NYGC has created a new scientific working group with the objective of bringing together researchers from our Institutional Founding Members, NYGC faculty, senior faculty, NYGC technology development and computational scientists, and affiliate members to discuss the underlying disease mechanisms in neuropsychiatric disease.