Slide background

Slide background
Slide background
Slide background

Loading Events
March
2020
25
Liam Holt, PhD

4:00 PM — 6:00 PM

New York University School of Medicine

See New York Genome Center’s lecture series, events and archives VIEW FULL CALENDAR

About

Liam Holt, PhD

Assistant Professor, Institute for Systems Genetics
New York University School of Medicine

“A Fantastic Voyage into the Cell: Crowding, Compression, Cancer and Neurodegeneration”

 

REGISTER

 

4-5PM: Lecture & Audience Q&A
5-6PM: Networking & Cocktail Reception

 

Tens of thousands of biochemical reactions occur simultaneously in the cell. Small molecules are channeled through metabolic pathways at blistering speed. Giant complexes assemble to orchestrate transcription and translation. ATP fuels the active transport of organelles along microtubules, and actin networks drive membrane remodeling and agitate the cytoplasm. All of this occurs within a crowded cell interior that approaches the physical limits where molecular jamming will occur. This extreme physical environment is both essential for life, and a potential liability. If cells become too dilute, they senesce and die. On the other hand, mechanical compression increases crowding and eventually stalls growth. Perturbations to crowding will change the balance of reaction rates in the cell. Crowding also drives biomolecular condensation, which in turn is thought to regulate myriad processes. We propose that perturbations to the physical properties of the cell interior through compression and dysregulation of growth pathways play an important role in both normal cell biology and disease, contributing to genome instability in cancer and the collapse of proteostasis in neurodegeneration.

 

Liam Holt attended the University of Bath, completed his PhD at UCSF in 2009, was a Bowes Fellow at UC Berkeley until 2016 and has been an Assistant Professor at NYU since 2016. His lab studies how the physical properties of the cell interior affect normal biology and disease. He is passionate about outreach and community. He founded Science Sketches, an online dictionary of science videos now partnered with XBio and MBoC, and Inspire Science, a symposium about maintaining happiness in a challenging career.

To learn more about Dr. Holt, visit his lab page.

 

Q&A Moderator:

Hemali Phatnani, PhD
Director, Center for Genomics of Neurodegenerative Disease
New York Genome Center

  • EVENING TALKS
    The New York Genome Center’s Evening Talks events feature distinguished experts from around the world sharing genomic insights and research. They are intended to showcase and explain high science to the non-scientific community. Speakers present the latest research findings and explain its implication for helping improve clinical care for a wide array of serious diseases. The lecture is followed by a lively question-and-answer session and a post-event reception of hors d’oeuvres and cocktails. These popular free public events are held in the Center’s state-of-the-art ground-floor auditorium starting at 6:00 pm. The Evening Talks Series is sponsored by The New York Community Trust – Pyewacket Fund.

  • Workshops
  • Computational Cancer Genomics Working Group Evening Lectures
    Computational Cancer Genomics Working Group is led by Simon Tavaré, PhD, NYGC and Columbia University, and Sohrab Shah, PhD, Memorial Sloan Kettering Cancer Center. This group will build collaborations that apply novel statistical approaches and population-level analyses to major cohorts in cancer genomics.

  • Neurodegenerative Disease Working Group Evening Lectures
    The NYGC is leveraging the success of the Center for Genomics of Neurodegenerative Disease (CGND) to extend our work across a range of neurodegenerative diseases that have pathways in common with ALS, including Alzheimer’s, Parkinson’s and Huntington’s diseases. The NYGC has created a new Neurodegenerative Disease Working Group, led by Alison Goate, DPhil, Icahn School of Medicine at Mount Sinai, Hemali Phatnani, PhD, NYGC, and Phil De Jager, PhD, MD, MMSc, Columbia University Irving Medical Center, with the objective of bringing together researchers from NYGC’s institutional founding members, NYGC faculty, senior faculty, NYGC technology development and computational scientists, and affiliate members to discuss the underlying disease mechanisms in neurodegenerative disease.

  • Neuropsychiatric Disease Working Group Evening Lectures
    The NYGC has created a new scientific working group with the objective of bringing together researchers from our Institutional Founding Members, NYGC faculty, senior faculty, NYGC technology development and computational scientists, and affiliate members to discuss the underlying disease mechanisms in neuropsychiatric disease.