Publications

Postvaccination SARS-COV-2 among Health Care Workers in New Jersey: A Genomic Epidemiological Study

Emergence of SARS-CoV-2 with high transmission and immune evasion potential, the so-called variants of concern (VOC), is a major concern. We describe the early genomic epidemiology of SARS-CoV-2 recovered from vaccinated health care professionals (HCP). Our postvaccination COVID-19 symptoms-based surveillance...

Authors:  Michael Zody   Andre Corvelo  

Performance assessment of DNA sequencing platforms in the ABRF Next-Generation Sequencing Study

Assessing the reproducibility, accuracy and utility of massively parallel DNA sequencing platforms remains an ongoing challenge. Here the Association of Biomolecular Resource Facilities (ABRF) Next-Generation Sequencing Study benchmarks the performance of a set of sequencing instruments (HiSeq/NovaSeq/paired-end 2 × 250-bp...

Authors:  Giuseppe Narzisi   Marta Byrska-Bishop   Wayne Clarke  

Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk

Dopaminergic neurons are critical to movement, mood, addiction, and stress. Current techniques for generating dopaminergic neurons from human induced pluripotent stem cells (hiPSCs) yield heterogenous cell populations with variable purity and inconsistent reproducibility between donors, hiPSC clones, and experiments. Here,...

Authors:  Will Liao  

Metastatic Pediatric Sclerosing Epithelioid Fibrosarcoma

Sclerosing epithelioid fibrosarcoma (SEF) is a rare and aggressive soft tissue sarcoma thought to originate in fibroblasts of the tissues comprising tendons, ligaments and muscles. Minimally responsive to conventional cytotoxic chemotherapies, greater than 50% of SEF patients experience local recurrence...

Authors:  Kazimierz Wrzeszczynski   Heather Geiger  

Emergence of Multiple SARS-CoV-2 Antibody Escape Variants in an Immunocompromised Host Undergoing Convalescent Plasma Treatment

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs), harboring spike protein N-terminal domain (NTD) or receptor-binding domain (RBD) mutations, exhibit reduced in vitro susceptibility to convalescent-phase serum, commercial antibody cocktails, and vaccine neutralization and have been associated...

Authors:  Michael Zody   Andre Corvelo  

Coding and noncoding variants in EBF3 are involved in HADDS and simplex autism

Background:  Previous research in autism and other neurodevelopmental disorders(NDDs) has indicated an important contribution of protein-coding (coding) de novo variants (DNVs) within specificgenes. The role of de novo noncoding variation has been observable as a general increase in genetic burden...

Authors:  Michael Zody   Giuseppe Narzisi   Marta Byrska-Bishop   Rajeeva Musunuri  

Recent ultra-rare inherited variants implicate new autism candidate risk genes

Autism is a highly heritable complex disorder in which de novo mutation (DNM) variation contributes significantly to risk. Using whole-genome sequencing data from 3,474 families, we investigate another source of large-effect risk variation, ultra-rare variants. We report and replicate a...

Authors:  Michael Zody   Marta Byrska-Bishop   Uday Evani  

Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19

Background:  Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has been associated with neurological and neuropsychiatric illness in many individuals. We sought to further our understanding of the relationship between brain tropism, neuro-inflammation, and...

Authors:  Andre Corvelo  

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