Slide background

Slide background
Slide background
Slide background

Wigler Lab

Dr. Wigler’s research is presently focused on the genomics of cancer and the genetics of autism and related disorders. Together with members of his laboratory they have demonstrated the feasibility of single cell sequencing for genomic analysis and expects this work will eventually improve the targeting of cancer treatments and lead to early and less invasive tests for cancer. His studies in human genetics led to the discovery of a vast unsuspected source of genetic variability known as copy number variation (CNV), and to the hypothesis that spontaneous mutation is a major contributor of autism.

  • +
    Mike Wigler

    IMG_8294

    Dr. Michael Wigler received his B.A. in mathematics from Princeton University in 1970, and his Ph.D. in Microbiology in 1978 from Columbia University. Upon completion of the doctoral degree, he went to Cold Spring Harbor Laboratory, where is now Professor. Together with Axel and Silverstein at Columbia, he discovered a technique still used for engineering mammalian cells to produce medicinally useful proteins. His team was the first to isolate a mammalian gene using gene transfer and among the first to identify a mutant human oncogene. His laboratory discovered the involvement of three members of the RAS family in human cancer; demonstrated the inheritance of DNA methylation patterns; pioneered the use of yeast as a model to explore more complex organisms, leading to an understanding of the RAS signaling pathway; co-invented (with Clark Still of Columbia University) encoded combinatorial synthesis, which has accelerated the discovery of new drug candidates; together with Nikolai Lisitsyn invented RDA, a method for comparative genome analysis that led to the discovery of the PTEN tumor suppressor (with Ramon Parsons of Columbia University) and the Kaposi’s sarcoma virus (by others at Columbia University); and developed representational genomic approaches that are used widely in genotyping. Dr. Wigler’s research is presently focused on the genomics of cancer and the genetics of autism and related disorders. Together with Jim Hicks and Nick Navin his laboratory demonstrated the feasibility of single cell sequencing for genomic analysis and expects this work will eventually improve the targeting of cancer treatments and lead to early and less invasive tests for cancer. His studies in human genetics led to the discovery of a vast unsuspected source of genetic variability known as copy number variation (CNV), and to the hypothesis that spontaneous mutation is a major contributor of autism. Dr. Wigler was elected to the National Academy of Sciences in 1989 and to the American Academy of Arts & Sciences in 1999, and is the recipient of many awards, including the Double Helix Medal in 2007.

This work was partially supported by a gift from the Simons Foundation.