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Satija Lab

Rahul Satija’s lab studies the causes and consequences of cellular heterogeneity in complex biological systems. His group is particularly interested in single cell genomics, with active development in both the dry and wet lab. The lab integrates novel statistical and machine learning-based methods with experimental analysis in order to better understand how cells work together to drive biological processes and behaviors.

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    • Villani AC, Satija, R, Reynolds, G, Sarkizova S, Shekhar K, Fletcher J, Griesbeck M, Butler A, Zheng S, Lazo S, Jardine L, Dixon D, Stephenson E, Nilsson E, Grundberg I, McDonald D, Filby A, Li W, De Jager PL, Rozenblatt-Rosen O, Lane AA, Haniffa M, Regev A, Hacohen N.

      Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors.

      Science. 2017 Apr 21.

    • Gierahn TM, Wadsworth MH 2nd, Hughes TK, Bryson BD, Butler A, Satija R, Fortune S, Love JC, Shalek AK.

      Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput.

      Nature Methods. 2017 Apr. 14. [Epub 2017 Feb 13]

    • Breton G, Zheng S, Valieris R, Tojal da Silva I, Satija R, Nussenzweig MC.

      Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c+ or CD141+ DCs.

      J Exp Med. 2016 Nov 18.  PMID: 27864467


This work was partially supported by a gift from the Simons Foundation.