Neville Sanjana’s lab develops technologies to understand how human genetic variants cause diseases of the nervous system and cancer. The lab employs a multi-disciplinary approach, combining genome engineering, pooled genetic screens, bioinformatics, electrophysiology, and imaging, to dissect the inner workings of the human genome and its dysfunction in autism and tumor evolution. The Sanjana lab is comprised of molecular engineers, biologists, neuroscientists, computer scientists and bioscience entrepreneurs who are passionate about creating new technologies for genomics and advancing human health. To find out more about current projects and open positions in the Sanjana lab, please visit the lab webpage.
The lab is also affiliated with the Department of Biology at New York University.
Neville Sanjana, PhD, is a Core Member and Assistant Investigator at the New York Genome Center. He holds a joint appointment as Assistant Professor in the Department of Biology and the Center for Genomics and Systems Biology at NYU. As a bioengineer, Dr. Sanjana is focused on creating new tools to understand the impact of genetic changes on the nervous system and cancer evolution. His research interests include developing pooled screening approaches for functional genomics and using gene editing to create pluripotent stem cell and human neuron models of neurodevelopmental disorders.
Dr. Sanjana is a recipient of the NIH Pathway to Independence Award and is a Next Generation Leader for the Paul Allen Institute for Brain Science. Prior to joining NYGC and NYU, he was a Simons Postdoctoral Fellow at the Broad Institute of Harvard and MIT. Dr. Sanjana holds a PhD in Brain and Cognitive Sciences from MIT, a BS in Symbolic Systems and a BA in English from Stanford University.
Wright JB, Sanjana NE.CRISPR Screens to Discover Functional Noncoding Elements.
Trends Genet. 2016 Sept. PMID: 27423542
Sanjana NEGenome-scale CRISPR pooled screens
Anal Biochem. 2016 Jun 1. PMID: 27261176
Boeke JD, Church G, Hessel A, Kelley NJ, Arkin A, Cai Y, Carlson R, Chakravarti A, Cornish VW, Holt L, Isaacs FJ, Kuiken T, Lajoie M, Lessor T, Lunshof J, Maurano MT, Mitchell LA, Rine J, Rosser S, Sanjana NE, Silver PA, Valle D, Wang H, Way JC, Yang L.The Genome Project-Write
Science. 2016 Jun 2. PMID: 27256881
Thibault Honegger, Moritz I. Thielen, Soheil Feizi, Neville E. Sanjana & Joel VoldmanMicrofluidic neurite guidance to study structure-function relationships in topologically-complex population-based neural networks
Scientific Reports 6, Article number: 28384 (2016)