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Sanjana Lab

Neville Sanjana’s lab develops technologies to understand how human genetic variants cause diseases of the nervous system and cancer. The lab employs a multi-disciplinary approach, combining genome engineering, pooled genetic screens, bioinformatics, electrophysiology, and imaging, to dissect the inner workings of the human genome and its dysfunction in autism and tumor evolution. The Sanjana lab is comprised of molecular engineers, biologists, neuroscientists, computer scientists and bioscience entrepreneurs who are passionate about creating new technologies for genomics and advancing human health. To find out more about current projects and open positions in the Sanjana lab, please visit the lab webpage.

The lab is also affiliated with the Department of Biology at New York University.

Visit Lab Website
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    Neville Sanjana

    Neville Sanjana, PhD, is a Core Faculty Member at the New York Genome Center (NYGC). He holds a joint appointment as Assistant Professor in the Departments of Biology, Neuroscience and Physiology at New York University (NYU).

    As a bioengineer, Dr. Sanjana is focused on creating new tools to understand the impact of genetic changes on the nervous system and cancer evolution. His research interests include bioengineering, genomics, neuroscience, cancer biology and systems biology.

    The Sanjana Lab develops new technologies and tools to understand how human genetic variants cause diseases of the nervous system and cancer. Dr. Sanjana and his research team use a multi-disciplinary approach, combining genome engineering, pooled genetic screens, bioinformatics, electrophysiology, and imaging, to dissect the inner workings of the human genome and its dysfunction in tumor evolution and autism.

    Utilizing new technologies for large-scale DNA synthesis, gene editing and next-generation sequencing, the Sanjana Lab has developed pooled screening approaches for functional genomics, creating CRISPR libraries to target the noncoding genome. Dr Sanjana has identified novel genetic drivers of melanoma drug resistance, drivers of metastasis in vivo, and mechanisms used by tumors to evade immunotherapy.  One of the major goals of the Sanjana Lab is to continue expanding the genome engineering toolbox to further scientific understanding of the noncoding genome and its vital  role in human health and disease.

    A recipient of the Kimmel Scholar Award and the NIH Pathway to Independence Award, Dr. Sanjana is also a Next Generation Leader for the Paul Allen Institute for Brain Science. Prior to joining the NYGC and NYU, he was a Simons Postdoctoral Fellow at the Broad Institute of Harvard and MIT. Dr. Sanjana holds a PhD in Brain and Cognitive Sciences from MIT, a BS in Symbolic Systems and a BA in English from Stanford University.

  • SELECTED PUBLICATIONS

    • Vikram Khurana, Jian Peng, Chee Yeun Chung, Pavan K. Auluck, Saranna Fanning, Daniel F. Tardiff, Theresa Bartels, Martina Koeva, Stephen W. Eichhorn, Hadar Benyamini, Yali Lou, Andy Nutter-Upham, Valeriya Baru, Yelena Freyzon, Nurcan Tuncbag, Michael Costanzo, Bryan-Joseph San Luis, David C. Schöndorf, M. Inmaculada Barrasa, Sepehr Ehsani, Neville Sanjana, Quan Zhong, Thomas Gasser, David P. Bartel, Marc Vidal, Michela Deleidi, Charles Boone, Ernest Fraenkel, Bonnie Berger, Susan Lindquist

      Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways

      Cell Systems, Available online 25 January 2017.

    • Sanjana NE & Zhang F.

      Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.

      Nature Protocols. 2017 Mar 23.

    • Wright JB, Sanjana NE.

      CRISPR Screens to Discover Functional Noncoding Elements.

      Trends Genet. 2016 Sept. PMID: 27423542

    • Sanjana NE

      Genome-scale CRISPR pooled screens

      Anal Biochem. 2016 Jun 1. PMID: 27261176

    • Boeke JD, Church G, Hessel A, Kelley NJ, Arkin A, Cai Y, Carlson R, Chakravarti A, Cornish VW, Holt L, Isaacs FJ, Kuiken T, Lajoie M, Lessor T, Lunshof J, Maurano MT, Mitchell LA, Rine J, Rosser S, Sanjana NE, Silver PA, Valle D, Wang H, Way JC, Yang L.

      The Genome Project-Write

      Science. 2016 Jun 2. PMID: 27256881

    • Thibault Honegger, Moritz I. Thielen, Soheil Feizi, Neville E. Sanjana & Joel Voldman

      Microfluidic neurite guidance to study structure-function relationships in topologically-complex population-based neural networks

      Scientific Reports 6, Article number: 28384 (2016)
      doi:10.1038/srep28384

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This work was partially supported by a gift from the Simons Foundation.