Sekar Kathiresan, MD
4:00 PM — 6:00 PM
Massachusetts General Hospital, Broad Institute and Harvard Medical School
Massachusetts General Hospital
Ofer and Shelly Nemirovsky MGH Research Scholar
Director of the Cardiovascular Disease Initiative
Associate Professor of Medicine
Harvard Medical School
“Leveraging the Genome to Understand Risk and Protection from Heart Attack”
Dr. Sekar Kathiresan seeks to understand the genetic basis for heart attack and use this knowledge to improve cardiac care. Beyond low density lipoproteins (LDL) cholesterol genes, he has shown that inherited heart attack risk may be due to monogenic mutations that impair clearance of triglyceride-rich lipoproteins or due to a polygenic model, that is, the cumulative impact of multiple DNA polymorphisms. He has developed a test for polygenic risk, and showed that statin therapy or a healthier lifestyle can modify polygenic risk. He has also identified gene mutations that confer resistance to heart attack by enhancing the clearance of triglyceride-rich lipoproteins, findings which have inspired the development of new medicines.
Dr. Sekar Kathiresan, a physician scientist and a human geneticist, is the Director of the Center for Genomic Medicine at Massachusetts General Hospital, Ofer and Shelley Nemirovsky MGH Research Scholar, Director of the Cardiovascular Disease Initiative at the Broad institute, and an Associate Professor of Medicine at Harvard Medical School. Dr. Kathiresan leverages human genetics to understand the root causes of heart attack and to improve preventive cardiac care. Among his scientific contributions, Dr. Kathiresan has helped highlight new biological mechanisms underlying heart attack, discovered mutations that protect against heart attack risk, and developed a genetic test for personalized heart attack prevention.
To learn more about Dr. Sekar Kathiresan’s research, visit Google Scholar – Sekar Kathiresan, MD.
+FIVE POINTSFive Points lecture series bring leading scientists from around the world for an in-depth discussion of their work with students, researchers and clinicians from the New York Genome Center, its member institutions, and others in the medical/scientific community. While Five Points lectures are free and open to the general public, these lectures are most beneficial to scientists, clinicians and researchers who wish to accelerate their research through the use of DNA sequencing technology and bioinformatics. Five Points lectures often frame five or so key points, in a nod to the series’ name — followed by 15 minutes of Q&A, and 30 minutes of networking over hors d’oeuvres and cocktails. These afternoon events are held in the Center’s state-of-the-art ground-floor auditorium starting at 4 pm.
+EVENING TALKSThe New York Genome Center’s Evening Talks events feature distinguished experts from around the world sharing genomic insights and research. They are intended to showcase and explain high science to the non-scientific community. Speakers present the latest research findings and explain its implication for helping improve clinical care for a wide array of serious diseases. The lecture is followed by a lively question-and-answer session and a post-event reception of hors d’oeuvres and cocktails. These popular free public events are held in the Center’s state-of-the-art ground-floor auditorium starting at 6:30 pm. The Evening Talks Series is sponsored by The New York Community Trust – Pyewacket Fund.
+New York Cancer Genomics Research NetworkTo advance collaborative efforts on cancer genomics, the New York Genome Center (NYGC) hosts meetings on the first Tuesday of every month to bring together leading cancer researchers, clinicians and postdocs from the NYGC’s Institutional Founding Members and other key academic institutions. The organizers include Drs. Harold Varmus (Weill Cornell Medicine & NYGC), Marcin Imielinski (Weill Cornell Medicine & NYGC), Ross Levine (Memorial Sloan Kettering Cancer Center) and Sohail Tavazoie (The Rockefeller University).