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May
2017
17
Benjamin Raphael, PhD
New York Genome Center
4:00 PM — 5:30 PM

Affiliation: Princeton University

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About

 

Affiliation: Princeton University

 

Professional Title: Interpretation and Evolution of Cancer Genomes

 

Professional Title: Professor, Department of Computer Science

 

Talk Abstract: In the past few years, somatic mutations in thousands of cancer exomes/genomes have been measured by high-throughput DNA sequencing. Despite this wealth of data, our understanding of the mutational landscape in cancer remains incomplete. In this talk, Dr. Raphael will describe computational approaches to translate cancer sequencing data into deeper insights about the processes that drive cancer development. These include techniques to identify combinations of mutations that perturb cellular networks, as well as algorithms to infer patterns of tumor evolution and metastasis.

 

Biography: Benjamin Raphael, PhD, is an Associate Professor in the Department of Computer Science at Princeton University. Previous to joining Princeton University, Dr. Raphael was an Associate Professor in the Department of Computer Science and Director of the Center for Computational Molecular Biology (CCMB) at Brown University. His research focuses on the design of algorithms for genome sequencing and interpretation. Recent interests include structural variation in human and cancer genomes, and network/pathway analysis of genetic variants. Dr. Raphael received an SB in Mathematics from MIT, a PhD in Mathematics from the University of California, San Diego (UCSD), and completed postdoctoral training in Bioinformatics and Computer Science at UCSD. He is the recipient of an NSF CAREER award, a Career Award from the Burroughs Wellcome Fund and a Sloan Research Fellowship.

 

To read more about Dr. Benjamin Raphael’s research, please visit: Google Scholar – Benjamin Raphael, PhD

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      Named for an early Manhattan crossroads – remembered as a rowdy but cosmopolitan gathering place, and as a nexus for progress in public health – the Five Points Lectures bring outstanding scientists from near and far, to discuss their work in technical detail* with researchers and clinicians from institutions served by NYGC, in order to strengthen our grasp of key biological questions and methods. Speakers present fresh and intriguing findings, along with thoughtful views on their respective fields, in full scientific depth. Talks last roughly 45 minutes — often framing five or so key points, in a nod to the series’ name — followed by 15 minutes of open Q&A, and 30 minutes of networking.

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