Slide background

Slide background
Slide background
Slide background

Loading Events
Ben Voight, PhD
New York Genome Center
4:00 PM — 5:30 PM

Computational Approaches to Identify Meaningful Complex Disease Loci in the Human Genome

See New York Genome Center’s lecture series, events and archives VIEW FULL CALENDAR


Associate Professor, Department of Systems Pharmacology and Translational Therapeutics and the Department of Genetics


University of Pennsylvania


“Computational approaches to identify meaningful complex disease loci in the Human Genome.”


Abstract: Thousands of associated loci for complex traits and diseases – hematopoietic traits, type 2 diabetes, heart disease, and beyond – are now available. However, leading associated variants implicate non-coding variation, a fact that has slowed progress on novel biological and therapeutic discoveries. Thus, a key challenge that has emerged is how to incorporate human genetic association data – coupled with other types of information – to identify the most biologically or therapeutically actionable loci from the “omnigenic” genetic architecture to deeply study.


To take on this challenge, Dr. Voight will describe his work using two types of computational strategies. The first considers the use of multi-phenotypes to ‘scan’ the genome to identify loci with consistent, localized, and synergistic directional evidence of disease. His lab’s leading analysis for type 2 diabetes and coronary heart disease will be presented. The second approach uses established loci for disease to build a model (penalized regression) to identify functional genomic regulatory features that predict these established sites. They demonstrate that our model outperforms competing functional prediction algorithms, with the benefit that the etiologically relevant features that are selected provide a modicum biological interpretability. Dr. Voight will discuss applications of the proposed approach to type 2 diabetes and platelet-related traits.



Biography: Ben Voight, PhD, received his PhD from the University of Chicago, advised by Drs. Jonathan Pritchard and Nancy Cox, focused on studies of natural selection and demographic inference in human populations.


As a postdoctoral fellow and research scientist from 2006-2011, Dr. Voight worked with Drs. David Altshuler and Mark Daly at Massachusetts General Hospital and the Broad Institute. There, he led development of computational pipelines and applications toward identifying common genetic variation associated complex phenotypes, particularly type 2 diabetes and heart disease, as well as application of the framework of Mendelian Randomization to perform causal inference using human genetics data.


He is currently an Associate Professor in the Department of Systems Pharmacology and Translational Therapeutics and the Department of Genetics at the University of Pennsylvania. He serves as vice-chair for the Genomics and Computational Biology Program there. In 2012, Dr. Voight was selected as an Alfred P. Sloan Foundation Fellow. He also recently received a Presidential Early Career Award for Scientists and Engineers.


Dr. Voight is a population geneticist and computational biologist whose research focuses on the burden and impact of complex disease, with the terminal aim of translating human genetic observations into targetable mechanisms, evolutionary insights, and new candidates for therapeutics development. Using his population and statistical genetics expertise, his lab develops computational methods and analyzes large-scale human genomics data to discern the evolutionary history and genetic basis of complex disease.


To read more about Dr. Ben Voight’s research, please visit: Google Scholar – Ben Voight, PhD

  • +
    Five Points lecture series bring leading scientists from around the world for an in-depth discussion of their work with students, researchers and clinicians from the New York Genome Center, its member institutions, and others in the medical/scientific community. While Five Points lectures are free and open to the general public, these lectures are most beneficial to scientists, clinicians and researchers who wish to accelerate their research through the use of DNA sequencing technology and bioinformatics. Five Points lectures often frame five or so key points, in a nod to the series’ name — followed by 15 minutes of Q&A, and 30 minutes of networking over hors d’oeuvres and cocktails. These afternoon events are held in the Center’s state-of-the-art ground-floor auditorium starting at 4 pm.

  • +
    The New York Genome Center’s Evening Talks events feature distinguished experts from around the world sharing genomic insights and research. They are intended to showcase and explain high science to the non-scientific community. Speakers present the latest research findings and explain its implication for helping improve clinical care for a wide array of serious diseases. The lecture is followed by a lively question-and-answer session and a post-event reception of hors d’oeuvres and cocktails. These popular free public events are held in the Center’s state-of-the-art ground-floor auditorium starting at 6:30 pm. The Evening Talks Series is sponsored by The New York Community Trust – Pyewacket Fund.

  • +