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OPPORTUNITIES

  • Academic

    Each faculty member of the NYGC leads a laboratory of post doctoral researchers, lab associates and scientific staff. They integrate their genomic expertise with the work that we are doing NYGC, working in collaborative research relationships both inside NYGC and with academic institutions. Our Faculty members hold joint appointments at our Institutional Founding Members while also managing their independent laboratories housed at the NYGC and conducting ground-breaking and collaborative genomic research.
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      Postdoctoral Associate, Sanjana Lab

      Job Description

      The Sanjana Lab at the New York Genome Center and NYU’s Department of Biology and Center for Genomics and Systems Biology is looking for an energetic and motivated individual to work as a Postdoctoral Associate within a highly creative and dynamic research team of scientists, engineers, and life science entrepreneurs.

      The Sanjana lab works at the intersection of genomics, bioengineering and neuroscience. We are curious about many things and are passionate about what we do. We primarily develop new technologies for hacking and understanding biological systems. We try to learn from nature and to re-purpose what we learn to gain deeper insights into how genomes and neural systems function. In the lab, we modify genomes, perform high-throughput screens, differentiate human neurons from stem cells, watch synapses rewire, find vulnerabilities in cancer cells and have a lot of fun in the process. We aim to have a tangible impact on improving human health by creating new biological tools and fundamental biological discovery.

      Please include the following items with your application: 1) CV with a list of publications;   2) a short summary of your present and future research interests;   3) a list of three references and their contact information.

      Required Skills

      The ideal candidate will hold a PhD or MD-PhD, have prior research experience in molecular biology, chemistry, biochemistry, neuroscience, cancer biology and/or genomics and prior peer-reviewed publications. The candidate will be expected to plan and carry out research tasks independently and write-up/present findings on a regular basis.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
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      Postdoctoral Researcher, Lappalainen Lab

      Job Description

      About the New York Genome Center

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

      Position Description

      Dr. Tuuli Lappalainen’s research group is looking for a postdoctoral researcher to work on projects in computational genetics and functional genomics.

      The Lappalainen Lab (http://tllab.org) studies genetic variation in human populations affecting molecular, cellular, and high-level traits and diseases. We use both computational and experimental methods to study these questions, with an interdisciplinary integration of approaches from computational genetics, population genetics, functional genomics, and molecular genetics. Our particular focus is on integration of large-scale genome and transcriptome sequencing data sets. We are part of several large consortia, including GTEx and MoTrPAC.

      We are looking for a computational postdoc to join our team (currently 8 people). Possible projects include, but are not limited to, genetic and environmental interactions on functional effects of genetic variants, methods development to integrate genetic data with molecular and high-level phenotype data sets, and population genetics of regulatory variation in humans.

      Required Skills

      • PhD in human genetics, functional genomics, or a related field;
      • Strong quantitative skills including proficiency in at least one programming language;
      • Experience of analysis of large-scale data sets is essential.
      • A publication record;
      • Excellent organization and communication skills, along with a high degree of independence and flexibility to thrive in a novel and rapidly changing research environment.

      Please include the following items with your application: 1) CV with a list of publications and preprints, 2) a one-page summary of your present and future research interests, 3) a list of three references and their contact information.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
  • Administration

    We believe that every team member is crucial as NYGC works towards our mission, be it in a scientific, technical, or administrative position. Our administration team plays a huge role in driving transformative change in biomedical and clinical care. This group includes external affairs, finance, legal, business development, project management, sponsored research and facilities.
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      Senior Director, NGS Process Engineering

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

      Position Description

      The New York Genome Center is looking for a highly motivated, independent, highly- experienced individual with strong experience in Next Generation Sequencing to improve NYGC’s sequencing operations. The Process Engineer will be responsible for leading, managing and overseeing a new organizational agenda, spanning across NYGC’s sequencing operations teams to improve all facets of our operations: efficiency, cost, throughput and turn- around time for wet-lab and informatics functions. Responsible for optimizing processes, troubleshooting lab methods, amending and developing protocols, bringing in new technologies and improving instrumentation in a rapidly growing sequencing facility. This role will interact closely with most teams at NYGC, especially our laboratories (production and clinical), project management, research computing, computational biology and software engineering, as well as the President/Chief Operating Officer.

      Job Responsibilities:

      • Responsible for leading the entire process-engineering effort at NYGC; requirements definition, design, development, optimization, troubleshooting, verification, validation, and transfer of automated processes, systems and workflows for NGS and analysis.
      • Ensure that all methods, protocols, work practices, SOPs, analysis and other processes across the entire sequencing and informatics groups are efficient, optimized for cost- savings, and are an optimal allocation of resources.
      • Evaluate current sequencing operation and data analysis procedures for optimization and improvement:
        • Work with internal stakeholders to encourage and gather feedback and suggestions, and drive the establishment of process requirements.
        • Present recommendations for changes, establish realistic timelines for execution, and communicate with partners.
        • Lead agile implementation of changes, and ongoing evaluation, incorporating input from other team members efficiently and effectively. Work with diverse partners to ensure that developed processes are robust, scalable and meet operational requirements.
        • Train and mentor employees to improve their understanding of process optimization and best working practices.
      • Work with Project Management and other teams to ensure our internal processes, systems and SOPs enable project deadlines to be achieved, and to reduce turn-around times, especially for clinical samples.
      • Work in cross-functional teams to provide troubleshooting expertise on developed processes.
      • Evaluate new methods, equipment and technologies to bring to the Center as needed, present recommendations to internal stakeholders, and lead or assist with implementation.
      • Drive forwards internal priorities cross-functionally to ensure swift implementation Including:
        • Work closely with the bioinformatics group to implement improved methods for QC, rapid analysis, fast annotation, and other developments that arise.
        • Work closely with the Innovation group and the Methods Development team to transition new technologies into the production lab.
        • Ensure all regulatory requirements are appropriately adhered to.

      Required Skills

      Required:

      • Ph.D. or equivalent in molecular biology, biotechnology, biochemistry, bioinformatics, genetics or a related field, and 10+ years’ related experience;
      • Broad-ranging managerial and process-engineering experience at a senior level in a high-throughput genomics laboratory;
      • Demonstrated ability to lead cross-functional process development, improvement, and troubleshooting;
      • Experience in streamlining workflows and developing automated laboratory processes and systems, including collecting and documenting requirements, developing concepts, design, verification and validation, implementation, and transfer/training;
      • Solid knowledge of NGS, related protocols and equipment, including significant Illumina- specific NGS experience;
      • Solid understanding of NGS data analysis;
      • Demonstrated skill in troubleshooting techniques and assessing sequencing-run quality;
      • Ability to lead across departments and to influence, rather than directly manage;
      • Familiarity with Microsoft Word, Excel, PowerPoint, and LIMS systems;
      • Excellent communication skills, detail oriented, and highly motivated; and,
      • Strong creative thinking and problem-solving skills.

      Desirable:

      • Automation experience;
      • Knowledge and experience of NYS regulatory approvals and/or CLIA environments;
      • Knowledge of project-management tools;
      • Knowledge and experience of IT systems for high-performance computing;
      • Knowledge and experience of software engineering responsibilities, processes, and extensive interactions with software engineering groups;
      • Experience of a high-throughput and/or commercial environment;
      • A positive attitude towards change; and,
      • Comfortable with risk.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
  • Bioinformatics

    We are proud to boast a world-class bioinformatics and computational biology organization to support the cutting edge genomics research and integrated genomics services that we offer at NYGC. Our collaborative bioinformatics team is passionate about understanding and modeling human genetic variation and researching how it can be used to generate clinically actionable results.
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      Bioinformatics Scientist, Pipeline

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      The New York Genome Center is looking for a highly motivated individual to join our computational biology group. As Bioinformatics Scientist, you will have primary technical responsibility for the maintenance, benchmarking, and continuous improvement of our germline genome analysis pipeline for all resequencing applications. You will also be responsible for overseeing daily operation of the pipeline and handling of custom analysis and reporting for NYGC staff and collaborator. You will supervise analysts and programmers performing development and analysis in this area. You should have significant experience in DNA sequencing analysis, including familiarity with commonly used algorithms for alignment, variant calling, and structural variant calling. Expertise in one or more common disease areas would be ideal. You should also be familiar with standard statistical methods for data QC and be comfortable evaluating and presenting both production metrics and scientific results. Collaboration with other members of the computational biology team as well as external collaborators and customers is paramount. Publication of developed methods and scientific findings is encouraged.

      Job duties will include, but are not limited to:

      • Primary technical responsibility for maintenance, improvement, and operation of the germline sequencing analysis pipeline;
      • Analyze sequencing data using established workflows;
      • Stay current on innovations in DNA sequencing analysis;
      • Recommend and implement changes to the sequencing pipeline based on state-of-art;
      • Development of novel sequence analysis methods where off-the-shelf methods are inadequate;
      • Generate and track appropriate quality metrics for high throughput sequencing operations;
      • Work with internal staff and collaborators to implement new methods or prototype and benchmark customized analysis and annotation pipelines;
      • Work with the clinical team to manage transfer of research pipelines to the clinical lab as needed;
      • Work with the software engineering team to ensure pipeline upgrades and new pipelines are properly implemented in our production workflow manager;
      • Assist, collaborate, and consult with internal/external researchers on analysis of genomic data;
      • Interpret and present analysis results to coworkers and collaborators;
      • Publish results in scientific journals and give presentations at conferences.

      Required Skills

      • PhD. in bioinformatics, computational biology, genetics, computer science or similar;
      • Experience in DNA sequencing analysis, including alignment, variant calling, structural variant calling, and variant annotation;
      • Familiarity with the human genome and its annotation, experience in human disease genetics a plus;
      • Proficiency in utilizing data from public resources such as Genome in a Bottle, 1000 Genomes, ExAC, and GnomAD;
      • Proficiency in R/Matlab, and one or more programming languages such as Python, Perl, Java, or C/C++, willingness to learn new programming languages as necessary to collaborate at NYGC;
      • Experience working in Linux and running tasks in a cluster environment (e.g. SGE);
      • Experience or training in statistics or machine learning preferred, at minimum sufficient statistical knowledge to develop and interpret standard QC metrics for sequencing;
      • Experience working in teams centered around a biological question and with external collaborators;
      • Excellent written and verbal communication skills.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
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      Senior Bioinformatics Analyst

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities. 

      Position Description

      The New York Genome Center is looking for a highly motivated, detail-oriented individual to join our informatics division in the bioinformatics and computational biology group. As Bioinformatics Analyst, you will be responsible for the analysis of next-generation sequencing (NGS) data, including but not limited to small & large scale genotype and sequence data. You will work as part of a team of analysts and scientists led by experienced bioinformatics scientists.

      Job duties might include:

      • Analyze sequencing data using established workflows;
      • Perform appropriate QC measures;
      • Implement, execute and document data analysis pipelines and workflows;
      • Benchmark new tools for sequencing data analysis and propose improvements;
      • Develop and apply novel analysis approaches;
      • Assist and collaborate with internal and external researchers on analyses of NGS data;
      • Summarize results in written or oral reports for bioinformatics scientists and internal researchers;
      • Assist bioinformatics scientists in preparing text and figures for manuscripts and external presentations.

      Required Skills

      •     MS degree with 3+ years of work/research experience or PhD in bioinformatics, computer science, or similar with demonstrable computational and statistical skills required;
      •     Familiar with various DNA sequencing QC analyses (eg. concordance, contamination, base quality);
      •     Familiar with various sequence analysis tools, including BWA, GATK, Picard, and samtools;
      •     Experience with pipeline development and management;
      •     Strong scientific programming skills – Python, R, bash;
      •     Additional programming skills in C++ or Java will be an advantage;
      •     Experience working in a Linux environment, experience with SGE or similar job scheduling preferred;
      •     Details-oriented, well-organized;
      •     Team oriented with excellent written and verbal communication skills;

      Preferred

      • Experience benchmarking various analysis tools;
      • Experience working with large datasets;
      • Background in disease-focused genomics and statistics;
      • Familiarity with commonly used public genomics datasets (e.g.; 1000 Genomes, TCGA, GTEx).

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

      APPLY
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      Bioinformatics Scientist, Cancer Genomics

      Job Description

      The New York Genome Center is looking for a highly motivated individual to join our computational biology group. As Bioinformatics Scientist, you will be responsible for handling of custom analysis and reporting for NYGC staff and collaborators. You will also share technical responsibility for the maintenance, benchmarking, and continuous improvement of our cancer genome analysis pipelines. You will collaborate with analysts and programmers performing development and analysis in this area. You should have significant experience in cancer genomics, including familiarity with commonly used algorithms for alignment, variant calling, and structural variant calling. Expertise in one or more common disease areas would be ideal. Collaboration with other members of the computational biology team as well as external collaborators and customers is paramount. Examples of recent projects involve tumor evolution, tumor heterogeneity, liquid biopsy, and prediction of personalized treatments (such as targeted therapies or immunotherapy). Publication of developed methods and scientific findings is encouraged. 

      Job duties will include, but may not be limited to:

      • Contribute to setup, management and maintenance of next generation sequencing (NGS) data analysis pipelines;
      • Analyze sequencing data using the established pipeline(s);
      • Stay current on innovations in DNA sequencing analysis;
      • Develop and implement innovative computational approaches for the analysis of large sequence datasets from NGS technologies;
      • Collaborate and consult with external and internal researchers on the analyses of NGS data;
      • Interpret and present the results of the computational and statistical analyses to collaborators and coworkers;
      • Work with the software engineering team to ensure pipeline upgrades and new pipelines are properly implemented in our production workflow manager;
      • Assist collaborators with data access, analysis, and interpretation;
      • Supervise and guide bioinformatics analysts/programmers;
      • Participate in grant application writing;
      • Publish results in scientific journals and give presentations at conferences.

      Required Skills

      • in bioinformatics, computational biology, genetics, computer science or similar;
      • 3 or more years work experience in Bioinformatics and Genomics with experience in cancer genomics;
      • Experience managing and working with next generation sequencing data required;
      • Extensive knowledge and experience in the use of existing bioinformatics tools and biological databases, as well as familiarity with cloud computing required;
      • Proficiency in python and R required, and one or more programming languages such as Perl, Java, or C/C++ desirable, as well as willingness to learn new programming languages as necessary to collaborate at NYGC;
      • Experience working in Linux and running tasks in a cluster environment (e.g. SGE) required;
      • Experience working in teams centered around a biological question and with external collaborators required;
      • Excellent written and verbal communication skills required;
      • Experience with design of sequence analysis algorithms desirable.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
  • IT and Computing

    This group develops and maintains the tools and infrastructure necessary to support our scientists as they tackle ground-breaking and large-scale data and genomic analysis. They are responsible for initiating and fostering external collaborations with technology partners, as well as ensuring that NYGC is a leader in the effective use of technology.
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      DevOps Engineer, Research Computing

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

      Position Description

      The DevOps Engineer will be a part of our rapidly expanding informatics division in supporting the high-performance computing and data storage environment.  This individual will be a member of the research computing team that manages a multi-petabyte data storage system to support a bioinformatics team that analyzes large data sets for genomic research.  This is an opportunity to use expertise and help power cutting-edge scientific research to apply to genomic discoveries.

      The DevOps Engineer will be responsible for the monitoring, movement, cleaning, and manipulation of data and play a key role in data management, data reporting and data pushes.  Job duties will include, but are not limited to, the following:

      • Collaborate with bioinformatics scientists, systems administrators, software engineers, users, and stakeholders to define requirements and specifications for data analysis workflows, accessing and managing scientific data, and data presentation;
      • Perform data migrations between internal systems, as well as to external sites;
      • Work with internal and external users to suggest and define data locations and organization;
      • Monitor and report data usage;
      • Track and report on the status of large data transfers;
      • Recommend ways to improve data reliability, efficiency, and quality;
      • Analyze performance and recommend storage solutions by running weekly usage reports;
      • Help troubleshoot any existing issues by investigating data flows;
      • Automate processes;
      • Improve documentation of changing data practices.

      Required Skills

      • Bachelor’s degree or equivalent work experience;
      • 3 Years Linux experience;
      • Python and bash scripting experience;
      • Ability to work with colleagues of various backgrounds (e.g. software engineering, project management, computational biologists, IT);
      • Excellent communication skills and proven ability to work directly with users to understand their needs and translate those into action plans and system improvements;
      • Must be able to work in a fast-paced, start-up like environment.

      Technologies in Use

      Linux, Isilon, Spectrum Scale (GPFS), Spectrum Archive (LTFSEE), VMWare, Python, Bash, Puppet, Foreman, Cisco UCS, Dell OpenManage, Zabbix, LibreNMS, Git, Jira, Globus/GridFTP, S3, Google Storage, GridEngine

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
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      DevOps System Administrator, Research Computing

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research. The NYGC is a VEVRAA Federal Contractor. 

      Position Description 

      The DevOps System Administrator will support the high-performance computing and data storage environment for NYGC. This individual will be a member of the research computing team and will be responsible for a wide variety of tasks as NYGC grows.

      Job duties will include, but are not limited to:

      • Assist with expanding size and functionality of compute and storage;
      • Assist internal and external users with utilizing compute and storage facilities;
      • Expand automation for systems expansion, management, and environment creation;
      • Assist building IaaS (compute and storage);
      • Install, configure and debug scientific software tools;
      • Responsibility for ensuring 24/7 functionality of compute and storage;
      • Provide technical expertise and guidance as a subject matter expert;
      • Act as technical lead on projects introducing new functionality and evaluating new technologies;
      • Create written documentation for other admins and users;
      • Work closely with scientific staff to ensure that the system is both usable and useful.

      Technologies in Use

      Linux, Isilon, Spectrum Scale (GPFS), Spectrum Archive (LTFSEE), VMWare, Python, Bash, Puppet, Foreman, Cisco UCS, Dell OpenManage, Zabbix, LibreNMS, Git, JIRA, Globus/GridFTP, S3, Google Storage, GridEngine

      Required Skills

      • At least 7 years’ experience in Unix / Linux system administration;
      • Strong Unix / Linux scripting skills for data movement and process automation;
      • Strong experience with automation tools such as Puppet and bash or Python scripting;
      • Experience with virtualized environments and infrastructure;
      • Must be able to work in a fast-paced, start-up like environment;
      • Excellent written and verbal communication skills.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
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      Jira Administrator

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

      Position Description

      The Jira Administrator will be a part of our rapidly expanding informatics division in supporting the high-performance computing and data storage environment.  This individual will be a member of the research computing team that manages a multi-petabyte data storage system to support a bioinformatics team that analyzes large data sets for genomic research.  This is an opportunity to use expertise and help power cutting-edge scientific research to apply to genomic discoveries.

      The Jira Administrator will be responsible for the maintenance, expansion and customization of our Atlassian platforms.  Job duties will include, but are not limited to, the following:

      • Maintain and expand Atlassian systems;
      • Manage product updates, including operational impact of features and changes;
      • Collaborate with bioinformatics scientists, systems administrators, software engineers, users, and stakeholders to define requirements and specifications for ticket workflows;
      • Implement and adjust custom workflows and custom fields and ticket routing in Jira;
      • Create custom dashboards;
      • Provide guidance and assistance to users;
      • Automate processes, including scripting integrations with other systems;
      • Improve documentation of changing practices.

      Required Skills

      • Bachelor’s degree or equivalent work experience;
      • 3 Years’ Jira experience;
      • Python and bash scripting experience;
      • Ability to work with colleagues of various backgrounds (e.g. software engineering, project management, computational biologists, IT);
      • Excellent communication skills and proven ability to work directly with users to understand their needs and translate those into action plans and system improvements;
      • Must be able to work in a fast-paced, start-up like environment.

      Technologies in Use

      Linux, Isilon, Spectrum Scale (GPFS), Spectrum Archive (LTFSEE), VMWare, Python, Bash, Puppet, Foreman, Cisco UCS, Dell OpenManage, Zabbix, LibreNMS, git, Jira, Globus/GridFTP, S3, Google Storage, GridEngine

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
  • Sequencing Operations

    NYGC is committed to providing the most advanced sequencing an analysis possible. Our facility was designed to accommodate ever-improving technology, and we have more sequencing capacity than any other single institution in the Tri-State area. The Sequencing Operations group is responsible for understanding and interpreting sequencing and primary bioinformatics data, and is central to the transformative work of NYGC.
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      Assistant Director, Molecular Diagnostics

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      Position Description: 

      The Assistant Director will closely work with the Director of the clinical laboratory to evaluate and interpret molecular diagnostics test results, participate in new and ongoing clinical assay development. This is an exciting opportunity for the right candidate to join a state-of-art clinical genomics laboratory and an expanding world-class next-generation genome center.

      Job Responsibilities:

      • Interprets and sign out clinical test results.
      • Work closely with the Director to develop and validation of new molecular tests.
      • Assist in preparing the laboratory for inspection by regulatory authorities.
      • Participate in the continued integration of laboratory information system, various 
software/systems for gene, variant curation, interpretation and clinical reporting.
      • Other duties as assigned.

      Required Skills

      • Experience in the performance and interpretation of sequencing data.
      • MD or PhD with clinical training and ABMGG certification in Clinical Molecular 
Genetics or ABMGG/ABP certification in Molecular Genetic Pathology.
      • New York State Certificate of Qualification or eligibility in genetic testing or 
oncology categories.
      • Excellent verbal and written communication skills and organizational skills are 
essential for this role.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

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  • Software Engineering

    Our Software Engineers develop cutting edge tools to drive the services at NYGC. This team works closely with bioinformatics, sequencing lab, scientists, program management, and more to develop scientific applications for high-volume data processing, analysis and management.
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      Software Engineer II, LIMS

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

       

      The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

       

      Position Description

      Reporting to the Senior Director of Software Engineering, the Software Engineer II, LIMS will work to plan, design, write and implement software and provide expertise and technical/analytic support for NYGC’s CLARITY Laboratory Information Management System (LIMS). The successful applicant will work closely with a multidisciplinary group of colleagues, including laboratory personnel with backgrounds in molecular biology and laboratory automation, as well as laboratory informatics. This role is essential to our sequencing operations and supports the maintenance and improvement of the LIMS system through the development and maintenance of software that addresses new and existing LIMS workflows, reporting and integration.

       

      The Software Engineer II, LIMS must demonstrate the ability to translate client needs and requirements, as well as develop and test tangible software solutions with the end users. The incumbent’s efforts will focus heavily on providing production support and break/fix resolution, the implementation of functional enhancements requested by clients and corresponding software releases (and associated processes), providing end-user support, as well as supporting, maintaining and managing both production and non-production environments.

       

      Job duties will include, but are not limited to:

      • Write and maintain custom code to extend the LIMS’ capabilities;
      • Maintain LIMS/Laboratory protocol configurations, and implement future protocol configurations;
      • Support integration with other software;
      • Implement instrument integrations and interactions with LIMS;
      • Work with the team members to establish a versioning system for LIMS configurations;
      • Troubleshoot system and application errors based on Standard Operating Procedures;
        • Document issues, impact and root cause and recommend remediation paths;
        • Work to rectify use and/or instrument errors, identifying possible downstream effects;
        • Engineer long-term solutions for recurring issues through root cause analysis and data analytics;
      • Work with members of the various customer groups (lab staff, project management, etc.) in an iterative fashion to collect requirements for new and enhanced functionality, demonstrate changes and integrate feedback;
      • Conduct User Acceptance Testing to ensure configuration is meeting business needs, and resolve any identified bugs;
      • Manage SQL databases and servers;
      • Manage environments and releases;
      • Maintain and, when necessary, create system documentation, including developing and/or updating training materials and delivering training to end-users;
      • Ensure that the LIMS complies with all relevant regulatory standards.

      Required Skills

      • BS in Computer Science, computer engineering, or related field plus 3 years related experience; master’s degree plus 2 years related experience;
      • Experience working with any high-throughput production LIMS strongly preferred, with CLARITY a plus;
      • Basic programming skills required; experience with Python preferred;
      • Familiarity with XML/XPath and REST APIs is a plus;
      • Experience with source control systems (Git, SVN, VCS, etc);
      • SQL proficiency required, with PostgreSQL knowledge preferred;
      • Familiarity with molecular biology lab workflows and best practices, with next-generation sequencing laboratory experience preferred;
      • Ability to work as the sole support engineer and as a member of a team to deliver quality code under tight deadlines;
      • Ability to document and report troubleshooting procedures and resolutions;
      • Excellent communication skills and a proven ability to work directly with customers in a patient, courteous and diplomatic fashion to understand their needs and translate those into actionable software requirements;
      • Detail orientated with strong organizational skills.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

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    • +
      Data Engineer, Software Engineering

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

       

      Position Description

      **THIS IS NOT A HADOOP-FOCUSED ROLE**

      Put your data engineering skills to use supporting our rapidly expanding informatics division in supporting high-throughput data processing and management systems. This is an opportunity to learn bioinformatics and use your expertise to help power cutting-edge scientific research to apply genomic discoveries to the clinical care of patients with diseases such as cancer, ALS, Alzheimer’s, and inflammatory diseases. No prior experience in genome biology is required.

       

      The Data Engineer will support our rapidly expanding software engineering division. The ideal candidate will be a positive, enthusiastic team player with experience developing solutions (software, methods, analyses, reports) for large-scale data analysis. Job duties will include, but are not limited to, the following:

      • Collaborate with bioinformatics scientists, IT, users, and stakeholders to define requirements and specifications for data analysis workflows, accessing and managing scientific data, and data presentation;
      • Prototype, develop, deploy, document, and support production-quality, fault-tolerant, high-performance software solutions focused on data analysis and management;
      • Develop expertise in the scientific and computational resources of the Center;
      • Participate in the management of NYGC’s large scale automated data pipelines, including analysis and transport;
      • Recommend ways to improve data reliability, efficiency, and quality.

      Required Skills

      The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

      • BS in computer science, mathematics, or related field; or 4 years of directly-aligned field experience;
      • 3 years of Linux experience;
      • Ability to work independently to deliver quality methods, code, and analyses under tight deadlines;
      • Ability to work with colleagues of various backgrounds (e.g. software engineering, genome science, wet lab);
      • Proficiency in Python or Java;
      • Experience with relational databases (e.g. PostgreSQL);
      • Experience with version control and source code management systems (e.g. git);
      • Familiarity with modern web development for data presentation is a plus;
      • Excellent communication skills and proven ability to work directly with customers to understand their needs and translate those into actionable software and analysis requirements;
      • Outstanding time management skills and attention to detail;
      • Must be able to diligently and clearly document work, including: tasks, methods, processes, and analyses;
      • Ability to make decisions with incomplete information and produce results in a timely fashion;
      • Ability and desire to learn new skills and techniques;
      • Must be able to work in a fast-paced, start-up like environment.

       

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

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    • +
      Senior UI and Visualization Software Engineer

      Job Description

      Our Software Engineers develop cutting edge tools to drive the services at NYGC. This team works closely with bioinformatics, sequencing lab, scientists, program management, and more to develop scientific applications for high-volume data processing, analysis and management.

      We are searching for a senior software engineer to lead the implementation of novel data visualization tools and overall user interface development for a new Genomics Data Repository to serve the broad genomic medicine community, and particularly our collaborating New York medical centers.

      Essential duties and responsibilities will include, but are not limited to, the following:

      • Collaborate with bio-informatics scientists, clinical researchers and other stakeholders to gather requirements for a genomic and clinical data repository and associated interfaces and visualization tools.
      • Work with a leading scientific visualization designer to implement graphical interfaces and repository requirements to develop the toolset.
      • Participate as a member of the data repository group in defining overall data, domain, and user requirements for the repository product.
      • Prototype, develop, test, deploy, document, and support production-quality software.
      • Assist with development of other parts of the project as requirements dictate.
      • Integrate with and build connections to other genomic repositories.
      • Build and manage secure interfaces and access to private data.
      • Be interested in and willing to learn about genomics and the infrastructure requirements for supporting genomic sciences.

       

      Required Skills

      The ideal candidate will be a pragmatic team player with experience developing and supporting production-quality software, with experience in data visualization, user interfaces, and usability.  Knowledge of big data environments is useful, as is experience in scientific environments.  Knowledge of genomics is not required.

      The requirements listed below are representative of the knowledge, skill, and ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

      • BS in Computer Science, Computer Engineering, or related field plus 10 years related experience; master’s degree plus 8 years related experience, or equivalent combination of education and experience.
      • UI and visualization expertise is needed.
      • Ability to produce readable, documented code is essential.
      • Proficiency in D3, JavaScript, and JS frameworks (such as React or Angular2) is important.
      • Ability to develop code anticipating additions and changes, and supporting modifiability and modularity is important.
      • Ability to work in a fast-paced environment and flexibility to work with changing requirements is essential. The entire field of genomics is evolving rapidly and the tools needed to support it must change as well.
      • Effective written and oral communication skills.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

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    • +
      Senior Software Engineer II

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

      Position Description

      The New York Genome Center is looking for a highly motivated, independent but team-oriented software engineer to support the expanding Informatics division in developing high-throughput pipelines and large-scale data management systems. Our Software Engineers develop cutting edge tools to drive the services at NYGC. This team works closely with bioinformatics, sequencing lab, scientists, program management, and more to develop scientific applications for high-volume data processing, analysis and management.

      Essential duties and responsibilities will include, but are not limited to, the following:

      • Collaborate with bio-informatics scientists, clinical researchers and other stakeholders to gather requirements for data processing pipelines, analysis tools, user interfaces, and data repositories.
      • Prototype, develop, test, deploy, document, and support production-quality software.
      • Assist with development of other parts of the project as requirements dictate.
      • Build and manage secure interfaces and access to private data.
      • Be interested in and willing to learn about genomics and the infrastructure requirements for supporting genomic sciences.

      Required Skills

      The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

      • BS in Computer Science, Computer Engineering, or related field plus 10 years related experience; master’s degree plus 8 years related experience, or equivalent combination of education and experience;
      • Ability to produce readable, documented code is essential;
      • Proficiency in Java or Python is required;
      • Experience with relational databases (mySQL or PostgreSQL) is required;
      • Ability to work in a fast-paced environment and flexibility to work on variety of projects and changing priorities is essential;
      • Experience with version control and source code management systems (e.g., GIT) is required;
      • Effective written and oral communication skills required;
      • UI expertise is desired;
      • Experience developing and supporting production-quality software for scientific applications, including analysis pipelines, user interfaces and data repositories is desired.
      • Knowledge of big data environments is useful, as is experience in scientific environments;
      • Knowledge of genomics is not required.

      Job Location
      New York, New York, United States

      Position Type
      Full-Time/Regular

       

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  • Technology Innovation

    Our Innovation Lab is currently testing several novel technologies with the potential to complement and enhance current technologies. Working with this group provides the opportunity to be on the cutting-edge of new technology and to perform innovative research that will shape the future of our industry.
    • +
      Associate Scientist, Technology Innovation

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

      Position Description

      We are looking for a highly motivated, independent but team-oriented Associate Scientist to work in our Technology Innovation Lab, NYGC’s research arm focusing on the creation and implementation of novel techniques in next-generation sequencing (NGS). This position will support multidisciplinary and collaborative research efforts in the lab at the interface of molecular biology, biological chemistry, and bio-engineering.

      Job duties include, but are not limited to:

      • Perform nucleic-acid quantification (UV absorbance and fluorescence) and quality control analyses (on-chip and gel electrophoresis);
      • Prepare sequencing-ready libraries using various commercial and novel protocols;
      • Perform quality control and quantification of sequencing libraries and interface with project management and production teams to arrange sequencing;
      • As needed, carry out procedures associated with both manual and automated extraction of DNA and RNA from FFPE samples, fresh tissue, serum, plasma, and/or other body fluids;
      • Analyze current processes for optimization and improvement, including documenting processes, proposing method improvements, and troubleshooting assays;
      • Stay current with literature and emerging trends in molecular biology, biological chemistry and bio-engineering fields and support lab efforts by learning and implementing a broad set of skills related to these fields; the right candidate must be both adaptable and a quick learner;
      • Conduct other laboratory work and tasks, as needed.

      Required Skills

      • Bachelor’s degree or higher in Molecular Biology, Biotechnology, Biochemistry, Engineering or related field;
      • Experience in a molecular biology lab is essential; additional experience with either chemistry or engineering is preferred; NGS experience highly desired;
      • Basic knowledge of molecular biology equipment and related protocols is essential (including RNA and DNA isolation, RNA and DNA quantification, qPCR, sequencing library preparation methods);
      • Familiarity with Microsoft Word, Excel, and PowerPoint, preferably with Mac OS;
      • Good general laboratory and organizational skills, including the ability to work independently and efficiently is essential;
      • Ability to multitask is a must, along with an orientation toward teamwork and cooperation;
      • Strong creative thinking and problem solving, excellent communication, and organizational skills required.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

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    • +
      Research Scientist, Technology Innovation
      Job Description
      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond by creating one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, data management, and research.

      Position Description

      The Technology Innovation Lab at NYGC conducts cutting-edge genomics research by leveraging tools and techniques from molecular biology, biological chemistry, and bio-engineering. A Scientist in the Technology Innovation Lab will develop creative protocols for sample and library preparation for Illumina and other next-generation sequencing (NGS) machines, and will push NYGC to the cutting edge of genomics through exploratory research.

      The candidate should be an independent thinker that can develop new protocols and novel schemes to solve complex problems. They will innovate in a revolutionary rather than evolutionary manner. The candidate will be expected to contribute to existing lab projects as well as identify unmet needs in genomics and design new approaches to address them.

      Given the interdisciplinary nature of our team, we are looking for candidates with extensive experience in molecular biology, biologically-focused chemistry, and/or bio-engineering. Specific responsibilities include, but are not limited to:

      • Monitor developments in sequencing technology and remain on the cutting edge of NGS technology and its many applications;
      • Design novel strategies to prepare samples and libraries for next-generation sequencing platforms, including methods that capture single-cell and multi-modal data, liquid biopsy, ultra-low quantities, long and linked reads, etc.;
      • Master and improve methods on the newest sequencing instruments, as they arrive;
      • Collaborate with new technology providers and provide expertise on next-generation sequencing to maintain NYGC at the forefront of sequencing and genomic analysis;
      • Be a source of knowledge for the team and the rest of the center in applying your skills to solve specific research problems;
      • Maintain significant knowledge of the current, relevant scientific literature, and communicate key developments to other lab members to ensure competitiveness of the group;
      • Publish and present current research through high-impact journals, posters and presentations in a timely manner to the benefit of the research community and to improve the profile of the Center;
      • Take an active part in lab meetings, sharing and improving the knowledge of the team and obtaining information relevant to the team’s goals.
      Required Skills
      • Relevant PhD degree with a strong molecular biology, chemistry, or engineering focus. A combination of these skills is preferred, with significant post-PhD experience highly preferred;
      • Extensive knowledge and experience of modern molecular biology and/or chemistry tools, including next-generation sequencing methods;
      • A proven track record in innovation and technology development is essential;
      • Ability to work in an independent manner with minimal supervision but having a strong collaborative personality;
      • Excellent communication skills and experience of writing first-author manuscripts for publication – able to present complex data in simple terms;
      • Excellent analytical and organizational skills;
      • Computing skills essential, and bioinformatics experience highly preferred.
      Job Location
      New York, New York, United States
      Position Type
      Full-Time/Regular
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