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OPPORTUNITIES

  • Academic

    Each faculty member of the NYGC leads a laboratory of post doctoral researchers, lab associates and scientific staff. They integrate their genomic expertise with the work that we are doing NYGC, working in collaborative research relationships both inside NYGC and with academic institutions. Our Faculty members hold joint appointments at our Institutional Founding Members while also managing their independent laboratories housed at the NYGC and conducting ground-breaking and collaborative genomic research.
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      Postdoctoral Researcher, Landau Lab

      Job Description

      About the New York Genome Center

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

      Position Description

      The Landau Lab at the New York Genome Center is seeking candidates for a postdoctoral position. The Landau lab develops computational and experimental tools to study the fundamental question of somatic evolution in health and disease. Our research is geared towards uncovering basic principles in evolutionary biology, using both patient derived samples and experimental systems for modeling cancer evolution in vitro and in vivo.

      The team includes a formidable group of scientists with interest and expertise which includes technology development, mathematical modeling, computer science and deep learning approaches, single-cell technology, genome and epigenome editing, liquid biopsy, high throughput approaches for optical barcodes and immunotherapy strategies.

      In addition to the basic science interest, we also seek to apply this knowledge to designing the next generation of precision medicine tools to overcome cancer evolution, as a central challenge to cancer cure today.

      Postdoctoral researchers will have the opportunity to develop an independent research program, work with leading collaborators across NYC and the Harvard/MIT community, and receive training in cutting-edge techniques for both the dry and wet lab.

      Required Skills

      • PhD in quantitative field (i.e. statistics, physics, mathematics or computer science) with a demonstrated interest in biological questions; or
      • PhD in a biological field with strong demonstrated programming and analytical skills or technology development.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

      APPLY
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      Postdoctoral Associate, Sanjana Lab

      Job Description

      The Sanjana Lab at the New York Genome Center and NYU’s Department of Biology and Center for Genomics and Systems Biology is looking for an energetic and motivated individual to work as a Postdoctoral Associate within a highly creative and dynamic research team of scientists, engineers, and life science entrepreneurs.

      The Sanjana lab works at the intersection of genomics, bioengineering and neuroscience. We are curious about many things and are passionate about what we do. We primarily develop new technologies for hacking and understanding biological systems. We try to learn from nature and to re-purpose what we learn to gain deeper insights into how genomes and neural systems function. In the lab, we modify genomes, perform high-throughput screens, differentiate human neurons from stem cells, watch synapses rewire, find vulnerabilities in cancer cells and have a lot of fun in the process. We aim to have a tangible impact on improving human health by creating new biological tools and fundamental biological discovery.

      Please include the following items with your application: 1) CV with a list of publications;   2) a short summary of your present and future research interests;   3) a list of three references and their contact information.

      Required Skills

      The ideal candidate will hold a PhD or MD-PhD, have prior research experience in molecular biology, chemistry, biochemistry, neuroscience, cancer biology and/or genomics and prior peer-reviewed publications. The candidate will be expected to plan and carry out research tasks independently and write-up/present findings on a regular basis.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
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      Bioinformatics Associate, Landau Lab

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

      Position Description

      The Landau Lab at the New York Genome Center is looking for a highly motivated, detail-oriented individual to join our efforts to study the basic principles of cancer evolution. As an Associate you will be trained in the analysis and interpretation of next-generation sequencing (NGS) data, originating from patient samples as well as experimental modeling of cancer evolution, under the guidance of advanced bioinformaticians.

      Job Duties:

      • Learn and assist in analyzing sequencing data using established pipelines;
      • Learn and perform appropriate QC measures;
      • Learn and develop/benchmark new tools for sequencing data analysis;
      • Assist and collaborate with internal and external researchers in interpretation of sequencing data.

      The successful applicants will be part of a fast-paced and dynamic team. The Landau Lab will provide significant on-the-job training. We seek a candidate who is motivated and can take independent initiative. This is an excellent opportunity for someone looking to gain experience to move into a PhD program within a couple of years, based on the new skillset they develop at New York Genome Center (though, this is not a requirement).

      Required Skills

      • BS or MS degree, or equivalent experience;
      • Team oriented with excellent written and verbal communication skills, collaboration skills and an eagerness to learn;
      • Exposure to NGS data analysis preferred;
      • A working understanding of code and script;
      • Training in statistics or machine learning a plus.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
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      Postdoctoral Researcher, Lappalainen Lab

      Job Description

      About the New York Genome Center

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

      Position Description

      Dr. Tuuli Lappalainen’s research group is looking for a postdoctoral researcher to work on projects in computational genetics and functional genomics.

      The Lappalainen Lab (http://tllab.org) studies genetic variation in human populations affecting molecular, cellular, and high-level traits and diseases. We use both computational and experimental methods to study these questions, with an interdisciplinary integration of approaches from computational genetics, population genetics, functional genomics, and molecular genetics. Our particular focus is on integration of large-scale genome and transcriptome sequencing data sets. We are part of several large consortia, including GTEx and MoTrPAC.

      We are looking for a computational postdoc to join our team (currently 8 people). Possible projects include, but are not limited to, genetic and environmental interactions on functional effects of genetic variants, methods development to integrate genetic data with molecular and high-level phenotype data sets, and population genetics of regulatory variation in humans.

      Required Skills

      • PhD in human genetics, functional genomics, or a related field;
      • Strong quantitative skills including proficiency in at least one programming language;
      • Experience of analysis of large-scale data sets is essential.
      • A publication record;
      • Excellent organization and communication skills, along with a high degree of independence and flexibility to thrive in a novel and rapidly changing research environment.

      Please include the following items with your application: 1) CV with a list of publications and preprints, 2) a one-page summary of your present and future research interests, 3) a list of three references and their contact information.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
  • Administration

    We believe that every team member is crucial as NYGC works towards our mission, be it in a scientific, technical, or administrative position. Our administration team plays a huge role in driving transformative change in biomedical and clinical care. This group includes external affairs, finance, legal, business development, project management, sponsored research and facilities.
  • Bioinformatics

    We are proud to boast a world-class bioinformatics and computational biology organization to support the cutting edge genomics research and integrated genomics services that we offer at NYGC. Our collaborative bioinformatics team is passionate about understanding and modeling human genetic variation and researching how it can be used to generate clinically actionable results.
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      Bioinformatics Scientist

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      The New York Genome Center is looking for a highly motivated individual to join our computational biology group. As Bioinformatics Scientist, you will have primary technical responsibility for the maintenance, benchmarking, and continuous improvement of our germline genome analysis pipeline for all resequencing applications. You will also be responsible for overseeing daily operation of the pipeline and handling of custom analysis and reporting for NYGC staff and collaborator. You will supervise analysts and programmers performing development and analysis in this area. You should have significant experience in DNA sequencing analysis, including familiarity with commonly used algorithms for alignment, variant calling, and structural variant calling. Expertise in one or more common disease areas would be ideal. You should also be familiar with standard statistical methods for data QC and be comfortable evaluating and presenting both production metrics and scientific results. Collaboration with other members of the computational biology team as well as external collaborators and customers is paramount. Publication of developed methods and scientific findings is encouraged.

      Job duties will include, but are not limited to:

      • Primary technical responsibility for maintenance, improvement, and operation of the germline sequencing analysis pipeline;
      • Analyze sequencing data using established workflows;
      • Stay current on innovations in DNA sequencing analysis;
      • Recommend and implement changes to the sequencing pipeline based on state-of-art;
      • Development of novel sequence analysis methods where off-the-shelf methods are inadequate;
      • Generate and track appropriate quality metrics for high throughput sequencing operations;
      • Work with internal staff and collaborators to implement new methods or prototype and benchmark customized analysis and annotation pipelines;
      • Work with the clinical team to manage transfer of research pipelines to the clinical lab as needed;
      • Work with the software engineering team to ensure pipeline upgrades and new pipelines are properly implemented in our production workflow manager;
      • Assist, collaborate, and consult with internal/external researchers on analysis of genomic data;
      • Interpret and present analysis results to coworkers and collaborators;
      • Publish results in scientific journals and give presentations at conferences.

      Required Skills

      • PhD. in bioinformatics, computational biology, genetics, computer science or similar;
      • Experience in DNA sequencing analysis, including alignment, variant calling, structural variant calling, and variant annotation;
      • Familiarity with the human genome and its annotation, experience in human disease genetics a plus;
      • Proficiency in utilizing data from public resources such as Genome in a Bottle, 1000 Genomes, ExAC, and GnomAD;
      • Proficiency in R/Matlab, and one or more programming languages such as Python, Perl, Java, or C/C++, willingness to learn new programming languages as necessary to collaborate at NYGC;
      • Experience working in Linux and running tasks in a cluster environment (e.g. SGE);
      • Experience or training in statistics or machine learning preferred, at minimum sufficient statistical knowledge to develop and interpret standard QC metrics for sequencing;
      • Experience working in teams centered around a biological question and with external collaborators;
      • Excellent written and verbal communication skills.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
  • IT and Computing

    This group develops and maintains the tools and infrastructure necessary to support our scientists as they tackle ground-breaking and large-scale data and genomic analysis. They are responsible for initiating and fostering external collaborations with technology partners, as well as ensuring that NYGC is a leader in the effective use of technology.
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      Senior Director, IT Infrastructure

      Job Description

      About the New York Genome Center

      The New York Genome Center (NYGC) is an independent, nonprofit, academic research organization that provides advanced genomic sequencing and analysis to the research and clinical care communities, and performs genomics research to better understand and treat human disease. NYGC was founded by and remains closely affiliated with twelve leading academic medical centers and research universities in the New York region and beyond, conducting research and projects with and for these institutions. In operation for three years, NYGC has created one of the largest genomics facilities in North America, with a current staff of 200 people located in Lower Manhattan.

      The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

      Position Description

      NYGC is seeking a Senior Director, IT Infrastructure to provide leadership, vision, strategic direction and oversight of NYGC’s infrastructure for data, computation, network and security. The IT department provides large-scale infrastructure support to teams involved in the analysis of genomic data, as well as to the administrative sides of the organization. The ideal candidate will have strong technical knowledge and will understand IT Infrastructure solutions and changing technologies.

      This position will be responsible for leading and managing multiple teams, in a 24X7 mission critical environment to architect, define, design, implement and maintain all required systems to fully support the Center. Teams include:

      • A research computing team that manages a multi-petabyte data storage system, multiple databases, and thousands of cores to support a bioinformatics team that analyzes large data sets for genomic research.
        • Oversight includes:
          • Storage & archive architecture;
          • High-performance computing infrastructure;
          • Capacity and integration with internal and external networking environment.
      • A networking and security team that is responsible for both internal and external networking, including an internal network that transfers petabytes of data per day, and meets high security standards in a regulated environment.
        • Oversight includes:
          • Network security and access control, including firewalls, centralized authentication and authorization services, intrusion detection, and other security measures;
          • Periodic external audits and penetration testing;
          • Adherence to regulatory requirements pertinent to network security;
          • Current network and implementation expansion and improvements;
          • Reviewing and improving security architecture.
      • An enterprise computing team responsible for enterprise IT functions
        • Oversight includes:
          • Deskside engineering and support of both PCs and MACs for end-users:
          • Infrastructure for desktop management, including password management, 2-factor authentication, system imaging, system consistency, desktop software, A/V, software upgrades, security patching, and onboarding and offboarding.
          • System administrators supporting the back-end infrastructure:
          • Management of 100s of virtual machines, email servers, active directory, access controls, including for large numbers of non-employee collaborators.
          • Management of infrastructure for enterprise solutions such as SAP.

      Other responsibilities include, but are not limited to, the following:

      • Manage escalated technical requests;
      • Oversee co-location facilities, and work with co-location management;
      • Constantly evaluate the strengths and weaknesses of current and emerging technologies (e.g. public cloud) and where they may be applicable in our environment to maintain the Center as a leader in the effective use of technology;
      • Develop and maintain external IT collaborations with technology partners; and
      • Continually investigate and identify, recommend, develop, implement and support cost-effective technology solutions to meet organizational needs;
      • Forecast IT Infrastructure capacity requirements;
      • Manage key vendor relationships and contract negotiations;
      • Manage financial responsibilities, including purchasing, budgeting and budget review, and conduct cost/benefit analysis for IT spending and grant applications;
      • Identify and procure hardware, software, and network resources to meet organizational needs;
      • Oversee review and implementation of organizational IT policies and procedures, including those for architecture, security, disaster recovery, standards, purchasing and service provision; ensure compliance with relevant SOPs;
      • Manage communication among the various IT teams described above;
      • Provide leadership and people management to multiple teams and team leaders, including mentoring, coaching, training, developing and building teams;
      • Directly engage the research community to understand evolving and projected requirements.

      Required Skills

      Experience and Qualifications

      Essential

      • BS or MS in computer science, information technology, or a computationally-intensive scientific discipline, or equivalent experience;
      • Minimum of 10 years’ experience developing and deploying high-performance, high-throughput IT solutions;
      • Experience with petabyte-scale data management and massively parallel infrastructure;
      • Experience developing and maintaining solutions to support large-scale, high-throughput applications and data, in a 24X7 mission-critical environment;
      • Strong working knowledge of network, storage and compute with emphasis on Linux, Cisco and Juniper, and massively parallel storage systems;
      • Solid understanding of high-performance computing architectures and technologies;
      • Strong working knowledge of IT Security;
      • Sound understanding of network, servers, data center operations, and disaster recovery;
      • Demonstrable experience in budget creation and management; and
      • Demonstrable experience in vendor management and negotiation.

      Desirable

      • Strong understanding of security and regulatory compliance (FISMA, ISO Standards), in a large-scale HIPAA environment;
      • Experience with protected health information or personally-identifiable information; and
      • Experience in a computational biology and bioinformatics setting.

      Personal Attributes

      • Smart, engaging, driven and technically savvy;
      • Able to adjust and change direction quickly;
      • Keen sense of urgency to match a fast-changing environment;
      • Possess a strong customer service orientation;
      • Excellent leadership and exceptional verbal and written communication skills; ability to provide technical depth, but also communicate the “big picture”;
      • Ability to think critically about emerging technologies and its implementation;
      • Proven ability to operate at both the strategic level as well as the tactical level;
      • Exhaustive knowledge of the technical resources in their field, strong opinions on how best to deploy those resources, and the ability to explain their reasoning both at a high level and in detail; and
      • Deep interest in using expertise to advance medical research.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
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      Data Engineer, Research Computing

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

      The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

      Position Description

      The Data Engineer will be a part of our rapidly expanding informatics division in supporting the high-performance computing and data storage environment.  This individual will be a member of the research computing team that manages a multi-petabyte data storage system to support a bioinformatics team that analyzes large data sets for genomic research.  This is an opportunity to use expertise and help power cutting-edge scientific research to apply to genomic discoveries.

      The Data Engineer will be responsible for the monitoring, movement, cleaning, and manipulation of data and play a key role in data management, data reporting and data pushes.  Job duties will include, but are not limited to, the following:

      • Collaborate with bioinformatics scientists, systems administrators, software engineers, users, and stakeholders to define requirements and specifications for data analysis workflows, accessing and managing scientific data, and data presentation;
      • Perform data migrations between internal systems, as well as to external sites;
      • Work with internal and external users to suggest and define data locations and organization;
      • Monitor and report data usage;
      • Track and report on the status of large data transfers;
      • Recommend ways to improve data reliability, efficiency, and quality;
      • Analyze performance and recommend storage solutions by running weekly usage reports;
      • Help troubleshoot any existing issues by investigating data flows;
      • Automate processes;
      • Improve documentation of changing data practices.

      Required Skills

      • Bachelor’s degree or equivalent work experience;
      • 3 Years Linux experience;
      • Python and bash scripting experience;
      • Ability to work with colleagues of various backgrounds (e.g. software engineering, project management, computational biologists, IT);
      • Excellent communication skills and proven ability to work directly with users to understand their needs and translate those into action plans and system improvements;
      • Must be able to work in a fast-paced, start-up like environment.

      Technologies in Use

      Linux, Isilon, Spectrum Scale (GPFS), Spectrum Archive (LTFSEE), VMWare, Python, Bash, Puppet, Foreman, Cisco UCS, Dell OpenManage, Zabbix, LibreNMS, Git, Jira, Globus/GridFTP, S3, Google Storage, GridEngine

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
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      Scientific System Administrator, Research Computing

      Job Description

      The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research. The NYGC is a VEVRAA Federal Contractor. 

      Position Description 

      The Scientific System Administrator will support the high-performance computing and data storage environment for NYGC. This individual will be a member of the research computing team and will be responsible for a wide variety of tasks as NYGC grows.

      Job duties will include, but are not limited to:

      • Assist with expanding size and functionality of compute and storage;
      • Assist internal and external users with utilizing compute and storage facilities;
      • Expand automation for systems expansion, management, and environment creation;
      • Assist building IaaS (compute and storage);
      • Install, configure and debug scientific software tools;
      • Responsibility for ensuring 24/7 functionality of compute and storage;
      • Provide technical expertise and guidance as a subject matter expert;
      • Act as technical lead on projects introducing new functionality and evaluating new technologies;
      • Create written documentation for other admins and users;
      • Work closely with scientific staff to ensure that the system is both usable and useful.

      Technologies in Use

      Linux, Isilon, Spectrum Scale (GPFS), Spectrum Archive (LTFSEE), VMWare, Python, Bash, Puppet, Foreman, Cisco UCS, Dell OpenManage, Zabbix, LibreNMS, Git, JIRA, Globus/GridFTP, S3, Google Storage, GridEngine

      Required Skills

      • At least 7 years’ experience in Unix / Linux system administration;
      • Strong Unix / Linux scripting skills for data movement and process automation;
      • Strong experience with automation tools such as Puppet and bash or Python scripting;
      • Experience with virtualized environments and infrastructure;
      • Must be able to work in a fast-paced, start-up like environment;
      • Excellent written and verbal communication skills.

      Job Location

      New York, New York, United States

      Position Type

      Full-Time/Regular

       

      APPLY
  • Sequencing Operations

    NYGC is committed to providing the most advanced sequencing an analysis possible. Our facility was designed to accommodate ever-improving technology, and we have more sequencing capacity than any other single institution in the Tri-State area. The Sequencing Operations group is responsible for understanding and interpreting sequencing and primary bioinformatics data, and is central to the transformative work of NYGC.
  • Software Engineering

    Our Software Engineers develop cutting edge tools to drive the services at NYGC. This team works closely with bioinformatics, sequencing lab, scientists, program management, and more to develop scientific applications for high-volume data processing, analysis and management.
  • Technology Innovation

    Our Innovation Lab is currently testing several novel technologies with the potential to complement and enhance current technologies. Working with this group provides the opportunity to be on the cutting-edge of new technology and to perform innovative research that will shape the future of our industry.